Clinical trials
Breast Cancer Surgery clinical trials
Below are recruiting breast cancer surgery clinical trials, each written for real people, not researchers. We’re tracking 1,162 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06263543RecruitingPhase 2
Sequencing antibody-drug conjugates in ER+, HER2-low breast cancer
This trial tests different sequences of antibody-drug conjugates (a type of targeted chemotherapy) for people with ER-positive, HER2-low or ultra-low metastatic breast cancer that has stopped responding to hormone therapy and has progressed on Enhertu. You must have had 1–4 prior chemotherapies for metastatic disease.
Miami, FloridaAges 18 years+ - NCT06238921RecruitingPhase 1/Phase 2
Study of two drugs and radiation for triple-negative breast cancer that spread to the brain
This trial tests adding the drugs sacituzumab govitecan and zimberelimab to targeted radiation therapy for people with triple-negative breast cancer that has spread to the brain. The goal is to see if this combination helps control the cancer longer.
Tampa, FloridaAges 18 years+ - NCT06178159RecruitingPhase 2
New drug combo before surgery for HER2-positive breast cancer
This trial tests a new combination of drugs (DV plus pertuzumab, with or without toripalimab) given before surgery for HER2-positive breast cancer. The goal is to see if this treatment can shrink the tumor and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06222788Recruiting
Plasma treatment during breast cancer lumpectomy
This trial tests a plasma treatment applied directly to the tumor site during a lumpectomy. It may help improve healing and reduce recurrence for people with early-stage breast cancer.
Montreal, QuebecAges 18 years+ - NCT06220214RecruitingEarly Phase 1
Study of chemo before breast cancer surgery with special mammogram
This trial tests whether a special mammogram with contrast can help doctors see how well chemotherapy is working before breast cancer surgery. It is for women who plan to have at least 4 rounds of chemo before their operation.
Stony Brook, New YorkAges 18 years+ - NCT06176261RecruitingPhase 2
Datopotamab deruxtecan for breast cancer with brain spread
This trial tests a new drug called datopotamab deruxtecan for people with HER2-negative breast cancer that has spread to the brain. It looks at how well the drug works against brain metastases.
Miami, FloridaAges 18 years+ - NCT06135714RecruitingPhase 3
Targeting limited breast cancer spread with focused therapy
This trial tests whether treating just the few spots where breast cancer has spread (called oligometastases) with radiation or surgery can help control the disease. It is for people whose cancer has spread to 3 or fewer places, each small in size, and who are healthy enough for local treatments.
Bunkyō-Ku, TokyoAges 18 years+ - NCT06129747RecruitingPhase 2
Repeat Lumpectomy and Daily Partial Breast Radiation for Cancer Return
This trial studies a second breast-conserving surgery followed by daily radiation to just the tumor area for people whose breast cancer has returned in the same breast. It aims to see if this approach is safe and effective, potentially avoiding a mastectomy.
Cleveland, OhioAges 19 years+ - NCT06150898RecruitingPhase 2
Ketorolac and pregabalin for estrogen receptor positive breast cancer before surgery
This trial tests whether two medications, ketorolac (a pain reliever) and pregabalin (a nerve pain drug), can help treat estrogen receptor (ER) positive breast cancer when taken before surgery. It may offer better pain control and possibly improve cancer outcomes.
Brussels, Brussels CapitalAges 18–70 - NCT06106477Recruiting
Intermittent fasting for women with early breast cancer
This trial studies whether a 14-hour night fast and 10-hour eating window can improve inflammation markers and quality of life in women with HR+/HER2- early breast cancer. You would start the fasting routine within three months of beginning hormone therapy.
Milwaukee, WisconsinAges 18 years+ - NCT06113016RecruitingPhase 2
Preventing frailty with fisetin and exercise in breast cancer survivors
This study tests whether adding a supplement called fisetin to an exercise program can help prevent frailty in women who have finished chemotherapy for early-stage breast cancer. If you are postmenopausal, have completed chemo within the last year, and can walk a certain distance, you may qualify.
Alhambra, CaliforniaAges Any age - NCT06127797Recruiting
MRI surveillance study for breast cancer survivors with dense breasts
This study is testing whether adding an MRI to your regular mammogram can help find any new breast cancers earlier. It is for women who have had breast cancer before and still have dense breast tissue, making mammograms harder to read.
Houston, TexasAges 18 years+ - NCT06127979Recruiting
Hormone therapy before surgery for breast cancer
This study looks at how a hormone-blocking medicine (endocrine therapy) given before surgery affects a marker called Ki67 in your breast cancer cells. The goal is to see if the medicine can slow the growth of the cancer, which may help doctors choose the best treatment for you.
New York, New YorkAges 18 years+ - NCT06105749Recruiting
Biennial contrast-enhanced mammogram for breast cancer survivors
This study tests whether getting a contrast-enhanced mammogram (CEM) every two years is effective for detecting breast cancer in women who have had breast cancer before. If you qualify, you will receive CEM instead of a standard mammogram to see if it helps find cancer earlier.
Bethel Park, PennsylvaniaAges 30–79 - NCT06115486Recruiting
Exercise to improve muscle after breast cancer treatment
This trial tests whether a structured exercise program (called EXERT-BCH) can help improve muscle mass in women who have finished breast cancer treatment. It involves group resistance training sessions and is designed to support recovery and strength.
Pittsburgh, PennsylvaniaAges 20–89 - NCT00898131Recruiting
Donate tissue samples during breast cancer surgery for future research
This study collects small tissue samples from women having surgery for breast cancer. The samples are stored to help researchers learn more and develop better treatments in the future.
Chicago, IllinoisAges Any age - NCT06052488Recruiting
Strength After Breast Cancer
This study tests a strength training program for women who have finished primary treatment for early-stage breast cancer. The goal is to see if it helps improve muscle strength and overall recovery.
Boston, MassachusettsAges 18 years+ - NCT06092892RecruitingPhase 2
Upfront targeted lymph node removal for early breast cancer
This trial is for women age 45 and older with early ER-positive breast cancer that has spread to the lymph nodes under the arm. It tests a surgery approach where the main tumor and only a few key lymph nodes (rather than many) are removed.
Los Angeles, CaliforniaAges 45 years+ - NCT06085742RecruitingPhase 2
CMC chemotherapy for early stage breast cancer
This trial tests a chemotherapy combination (CMC) for people with early-stage, hormone receptor-positive, HER2-negative breast cancer who have a high risk of recurrence. It aims to understand if this oral regimen is effective and tolerable.
Chicago, IllinoisAges 18 years+ - NCT06099769RecruitingPhase 2
Testing enzalutamide with or without mifepristone for AR-positive breast cancer
This trial tests if adding the drug mifepristone to the standard antiandrogen enzalutamide works better than enzalutamide alone or chemotherapy for people with a specific type of breast cancer that has androgen receptors. It aims to find a new targeted treatment option for triple-negative or ER-low breast cancer.
Birmingham, AlabamaAges 18 years+ - NCT05929768RecruitingPhase 3
Shorter chemo plus immunotherapy without anthracyclines for early TNBC
This Phase 3 trial tests whether a shorter course of chemotherapy plus immunotherapy can work as well as standard treatment for early-stage triple-negative breast cancer. It avoids anthracycline drugs and may help reduce exposure to those medicines if the shorter plan is effective and safe.
Birmingham, AlabamaAges 18 years+ - NCT03694756Recruiting
Testing special MRI to see tiny breast cancer structures
This study is testing whether a special MRI scan can help show tiny features inside breast tumors (TMEM). It’s mainly a “feasibility” study, meaning the team is checking if the scan can be done safely and clearly in different types of operable breast cancer.
The Bronx, New YorkAges 18 years+ - NCT06072612RecruitingPhase 3
Bria-IMT plus CPI vs standard care for advanced breast cancer
This trial tests a new combination of two immunotherapy drugs (Bria-IMT and a checkpoint inhibitor) against your doctor's choice of standard treatments. It is for people with advanced breast cancer that has spread and who have already tried several prior therapies.
Phoenix, ArizonaAges 18 years+ - NCT06064812RecruitingPhase 1/Phase 2
Testing a new drug for advanced ER-positive breast cancer
This trial tests an experimental oral drug (FWD1802) for women with a specific type of advanced breast cancer (ER-positive, HER2-negative) that has stopped responding to hormone therapy. It looks at whether the drug can slow or stop cancer growth, especially if you have an ESR1 mutation.
Hefei, AnhuiAges 18 years+
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Common questions
- Are there clinical trials for breast cancer surgery?
- Yes. Clin2 currently lists 1,162 recruiting breast cancer surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.