Clinical trials
Breast Cancer Surgery clinical trials
Below are recruiting breast cancer surgery clinical trials, each written for real people, not researchers. We’re tracking 1,192 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05901428RecruitingPhase 3
Check if two breast cancer treatments work better after surgery
This trial compares two treatment approaches in people with high-risk hormone-positive, HER2-negative breast cancer that has spread to certain lymph nodes. It looks at which option works best to lower cancer returning and to control the disease after surgery and initial chemotherapy.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT06693037Recruiting
Choosing next treatment after incomplete response in HER2+ breast cancer
This trial looks at the best next treatment for women with HER2-positive breast cancer who still have leftover cancer after surgery and standard pre-surgery treatment. It helps doctors choose the right therapy for you.
Beijing, Beijing MunicipalityAges Any age - NCT05878314Recruiting
Testing how hormones and tumor markers guide breast cancer treatment
This study looks at how planned hormone (endocrine) treatment, the menstrual cycle, and lab markers from the tumor may help doctors choose the best treatment for early-stage, hormone-receptor–positive, HER2-negative breast cancer. It may help personalize decisions, including what to do before surgery.
TübingenAges 18 years+ - NCT05181033RecruitingPhase 2
Lenvatinib plus letrozole versus fulvestrant for metastatic breast cancer
This Phase 2 study compares a combination medicine (lenvatinib plus letrozole) against fulvestrant to treat metastatic estrogen-receptor positive, HER2-negative breast cancer after the cancer has grown despite hormone therapy plus a CDK4/6 inhibitor. It may help by finding a more effective treatment option after your first lines have stopped working.
SingaporeAges 18–99 - NCT05856773RecruitingPhase 3
Standard vs shorter radiation to lymph nodes for breast cancer
This trial compares two ways of giving radiation to the breast/chest wall and nearby lymph nodes after breast surgery: a standard schedule versus a shorter “hypofractionated” schedule. It uses proton therapy and may help reduce treatment time while still controlling the cancer.
Scottsdale, ArizonaAges 19 years+ - NCT06541587Recruiting
Smart VR mindfulness for breast cancer patients on chemo
This study tests whether a virtual reality (VR) mindfulness program that responds to your heartbeat can help reduce stress and improve how well chemotherapy works for breast cancer. You will use a special VR headset during your hospital stay.
Taipei, Neihu DistinctAges 18 years+ - NCT06741540Recruiting
TDCS for breast cancer patients with mild to moderate depression
This trial tests if transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, can help improve mood and treatment outcomes in breast cancer patients with mild to moderate depression who are receiving neoadjuvant chemotherapy before surgery.
Hangzhou, ZhejiangAges 18–65 - NCT06830083Recruiting
Shorter radiation schedule after mastectomy with implant reconstruction
This trial is testing a shorter, higher-dose radiation schedule (hypofractionation) for women who have had a mastectomy and immediate breast reconstruction with implants. The goal is to see if this approach works as well as standard radiation while possibly being more convenient and causing fewer side effects.
Nanjing, JiangsuAges 18–65 - NCT07400523RecruitingPhase 3
Ribociclib for breast cancer with leftover disease after chemo
This trial tests ribociclib, a targeted therapy, for women with hormone receptor-positive, HER2-negative breast cancer who still have cancer cells in the breast or lymph nodes after initial chemotherapy. It aims to reduce the chance of cancer coming back.
Zhanjiang, GuangdongAges 18 years+ - NCT07514728Enrolling by invitation
Hyperbaric oxygen to slow breast cancer spread to lungs
This trial tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can slow the growth of breast cancer that has spread to the lungs. You would receive this treatment alongside standard care if your cancer has grown despite prior chemotherapy.
Jinan, ShandongAges 18–75 - NCT06195306RecruitingPhase 2
Low dose tamoxifen and omega-3 for breast cancer prevention
This study tests whether low-dose tamoxifen (a breast cancer prevention drug) or omega-3 supplements can lower breast cancer risk in postmenopausal women who are overweight and have a higher chance of getting the disease. The study lasts about 6 months and involves blood draws and a breast fluid test to see how the treatment affects breast cells.
Kansas City, KansasAges 45–74 - NCT06013514Recruiting
Study of Nagor Perle breast implants for reconstruction or cosmetic surgery
This study is following people who got Nagor Perle breast implants to see how they perform over time. It includes women getting implants for breast reconstruction, cosmetic augmentation, or revision surgery.
Manchester, United KingdomAges 18–65 - NCT07365267Recruiting
3D printed mesh for breast reconstruction after mastectomy
This trial tests a new 3D printed biodegradable mesh used during breast reconstruction right after a mastectomy for breast cancer. It aims to see how well the mesh works for cosmetic results and safety.
Xi'an, ShaanxiAges 18–70 - NCT07410494RecruitingPhase 1/Phase 2
Personalized donor cell therapy for advanced solid tumors
This trial tests a personalized cell therapy (CAR-NK) using donor immune cells that are engineered to find and attack one or two markers on advanced solid tumors. It may be an option for people whose tumors have these specific markers and have exhausted other treatments.
Beijing, Beijing MunicipalityAges 8–85 - NCT07503808RecruitingPhase 1
IDE034 for advanced solid tumors with B7-H3 or PTK7
This study tests a new drug called IDE034 for people with advanced solid tumors that have certain markers (B7-H3 and PTK7). The drug may help by targeting these markers on cancer cells, and the study checks if it is safe and effective.
Denver, ColoradoAges 18 years+ - NCT05887856Enrolling by invitation
Educational program to reduce pre-surgery anxiety in breast cancer
This trial tests whether a specially designed educational program can lower anxiety before breast surgery. It may help you feel more prepared and calmer leading up to the operation.
LahoreAges 18–70 - NCT05746897RecruitingPhase 1
First-in-human test of an anti-PVRIG drug for advanced cancers
This early-phase study tests NM1F (an anti-PVRIG antibody) in people with advanced solid tumors to see if it’s safe and whether it may work. It also includes pembrolizumab (a PD-1 “checkpoint” medicine), aiming to boost the immune system against the cancer.
Dallas, TexasAges 18 years+ - NCT03954431Recruiting
Lower-dose breast CT for clearer breast imaging
This study looks at a special breast CT scan done with a lower radiation dose to help produce clear breast images. You may be able to join if you are getting breast imaging or a biopsy for a possible breast issue and meet the safety and comfort requirements.
Tucson, ArizonaAges 40 years+ - NCT06165419RecruitingPhase 2
High-dose radiation for spine metastases from solid tumors
This trial tests a new way of giving high-dose radiation to solid tumors that have spread to the spine. It is for people whose spine is stable, have not had prior treatment to that area, and have only minor weakness (if any).
Stony Brook, New YorkAges 18 years+ - NCT06727487Recruiting
Ovarian suppression and exercise in young breast cancer patients
This trial tests whether adding a supervised exercise program helps women with hormone-positive breast cancer who are receiving ovarian suppression therapy. It looks at how exercise affects treatment side effects, quality of life, and long-term health.
MadridAges 18–45 - NCT05005403RecruitingPhase 1
Testing azirkitug for lung, head/neck, and other solid cancers
This Phase 1 study tests how a new medicine (azirkitug) behaves in the body and how safe it is, given by IV infusion alone or with other cancer drugs. It may help people with several advanced solid tumor cancers, especially after standard treatments have stopped working.
Duarte, CaliforniaAges 18 years+ - NCT07308717RecruitingPhase 4
Gabapentin for mastectomy recovery
This trial tests if gabapentin improves recovery after mastectomy. It studies how giving the drug before surgery affects pain and healing.
Basking Ridge, New JerseyAges 18–65 - NCT04457895Recruiting
Yoga and physical therapy program for hormone therapy breast cancer pain
This trial studies whether a combined physical therapy, yoga, and patient education program can reduce pain in people with non-metastatic breast cancer who are taking hormone therapy. It may help with pain and day-to-day comfort while you continue hormone treatment.
Libourne, AquitaineAges 18–99 - NCT05363189Recruiting
Improving recovery after breast reconstruction with belly-tissue flap
This study looks at ways to help your recovery after breast reconstruction using tissue moved from your lower belly (a DIEP flap). You may be asked to complete a questionnaire during the recovery period.
GothenburgAges 18–100
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Common questions
- Are there clinical trials for breast cancer surgery?
- Yes. Clin2 currently lists 1,192 recruiting breast cancer surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.