Clinical trials · Boston, MA
Cancer clinical trials in Boston
We’re tracking 800 recruiting cancer studies with a site in or near Boston — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Boston
- NCT07215910RecruitingPhase 3
Testing vorasidenib with temozolomide after radiation for advanced brain cancer
This trial tests whether adding the targeted drug vorasidenib to standard chemotherapy (temozolomide) after radiation helps people with a specific type of advanced brain cancer called IDH-mutant astrocytoma. It is for patients who have not had previous treatments like chemotherapy or radiation and whose tumors have certain genetic features.
Boston, MassachusettsAges 12 years+ - NCT05898594Recruiting
Lung cancer screening for high-risk Black adults
This study is designed to help Black adults at higher risk get lung cancer screening. It checks whether a screening approach can catch lung problems early and connect people to the right next steps.
Boston, MassachusettsAges 50–80 - NCT04166409RecruitingPhase 3
Selumetinib versus chemo for low-grade brain tumor in children
This trial studies whether the targeted drug selumetinib works better than standard chemotherapy (carboplatin and vincristine) for children and young adults with a specific type of low-grade glioma (grade 1 or 2). It may help shrink tumors and slow growth while comparing side effects between the two treatment approaches.
Boston, MassachusettsAges 2–21 - NCT04970056Recruiting
Pancreatic cancer risk and early-detection registry study
This study builds a database of people at higher risk for pancreatic cancer (or certain early warning findings) to help find better ways to detect the disease early. You may be asked to complete health questionnaires and possibly donate a blood/saliva/swab sample.
Boston, MassachusettsAges 18–90 - NCT07162337Recruiting
Diet education to lower colon cancer risk after polyp removal
This study tests whether a diet education program can change the balance of gut bacteria and bile acids to lower the risk of colorectal cancer in people who have had polyps removed.
Boston, MassachusettsAges 18–80 - NCT02269592Recruiting
Study blood marker changes in early, symptom-free blood cancers
This study follows people with early, “precursor” blood conditions to learn what changes in their blood or bone marrow signal progression. It may help doctors better predict outcomes and understand why some people develop symptom-causing cancer.
Boston, MassachusettsAges 18 years+ - NCT06426628Recruiting
Nasal swab test for lung nodule risk
This trial tests a new nasal swab test to help doctors better understand your risk if you have a small lung nodule. The test looks at cells from your nose to give more information about whether the nodule might be cancer, without needing a biopsy right away.
Boston, MassachusettsAges 29–85 - NCT04045470Recruiting
Skin-device test to find drugs for T-cell lymphoma lesions
This trial tests a tiny device placed directly into skin lymphoma spots to help identify which “candidate” drugs could work. It’s mainly aimed at people with measurable skin involvement from T-cell lymphoma, after they stop certain treatments for a set time.
Boston, MassachusettsAges 18 years+ - NCT06424327Recruiting
Lung cancer surgery registry
This study collects information from people having surgery to remove a small part of the lung (segmentectomy) for early-stage lung cancer. It helps doctors learn more about this surgery and its outcomes.
Boston, MassachusettsAges 18 years+ - NCT05281237Recruiting
Microwave ablation for small early lung cancer nodules
This trial studies a flexible “microwave heating” probe placed through the airways to treat small lung cancer nodules. It may help some patients avoid more invasive treatment by destroying the tumor during a bronchoscopy procedure.
Boston, MassachusettsAges 22 years+ - NCT06987890Recruiting
Geriatric assessment for older adults with lung cancer getting SBRT
This study looks at how a geriatric assessment can help older adults with early-stage lung cancer who are getting a precise type of radiation therapy called SBRT. The goal is to understand their needs and improve care.
Boston, MassachusettsAges 65 years+ - NCT06322888Recruiting
Exercise study for women with dense breasts
This trial tests if resistance and aerobic exercise can help prevent breast cancer in women with dense breast tissue. You would join a supervised exercise program to see if it reduces your risk.
Boston, MassachusettsAges 18–59 - NCT04421560RecruitingPhase 1/Phase 2
Testing pembrolizumab, ibrutinib, and rituximab for PCNSL
This Phase 1/2 study tests how well a combination of pembrolizumab, ibrutinib, and rituximab treats primary CNS lymphoma that came back or didn’t respond after prior brain treatment. It may help shrink the lymphoma and control it in the brain and fluid around the brain.
Boston, MassachusettsAges 18 years+ - NCT05668962RecruitingPhase 2
Study selpercatinib plus I-131 for RET thyroid cancer that cannot take iodine
This trial tests whether combining a targeted pill (selpercatinib) with a radioactive iodine dose (I-131) can shrink thyroid cancer that has spread and no longer responds to radioactive iodine. It is for RET fusion–positive (genetically driven) thyroid cancers where the cancer cannot reliably absorb iodine anymore.
Boston, MassachusettsAges 12 years+ - NCT05985161RecruitingPhase 2
Selinexor for wilms tumor and other solid tumors
This trial tests a drug called selinexor for children and young adults with certain types of solid tumors (like Wilms tumor, rhabdoid tumors, MPNST, or others with specific genetic changes) that have come back or not responded to standard treatment. Participants take selinexor pills to see if it can shrink or control their cancer.
Boston, MassachusettsAges 1 year+ - NCT05554393RecruitingPhase 2
Treating intermediate-risk AML in younger adults
This trial compares three different drug combinations for younger adults (18-59) with intermediate-risk AML. You will be assigned to one of three groups: standard chemotherapy (cytarabine + daunorubicin), that same chemotherapy plus venetoclax, or venetoclax combined with azacitidine.
Boston, MassachusettsAges 18–59 - NCT04468061RecruitingPhase 2
Study chemo drug plus immunotherapy for metastatic triple-negative breast cancer
This trial tests sacituzumab govitecan (an antibody-drug medicine) with or without pembrolizumab (an immune-system therapy) in people with metastatic triple-negative breast cancer. It may help by shrinking tumors and improving immune control, especially for patients with specific tumor marker results.
Boston, MassachusettsAges 18 years+ - NCT04924075RecruitingPhase 2
Belzutifan for cancers linked to VHL or HIF-2α changes
This Phase 2 study tests belzutifan (MK-6482) to treat certain advanced cancers caused by specific gene or disease changes, including VHL-related tumors and HIF-2α related tumors. It may help shrink tumors or slow their growth in people whose cancer matches these genetic or disease patterns.
Boston, MassachusettsAges 12 years+ - NCT07467772RecruitingPhase 2
Elacestrant for estrogen receptor-positive uterine sarcoma
This trial tests whether elacestrant, a drug that blocks estrogen, can help people with certain types of uterine sarcoma that have strong estrogen receptors. It may slow or stop cancer growth in tumors that rely on estrogen.
Boston, MassachusettsAges 18 years+ - NCT04504604Recruiting
Study matching rare cancer care with tumor DNA testing
This study looks at people with rare solid tumors or lymphoma to understand their cancer’s genetic changes. It collects blood and existing tissue samples (from standard care) for DNA testing and gathers health information to help improve knowledge about rare cancers.
Cambridge, MassachusettsAges 18 years+ - NCT05245500RecruitingPhase 1
Study drug for solid tumors with MTAP gene deletion
This Phase 1 trial studies MRTX1719, a new medicine, in solid tumors that have a missing MTAP gene (MTAP deletion). It aims to find the safest dose and check how the drug affects the tumor.
Brookline, MassachusettsAges 18 years+ - NCT05334069Recruiting
Blood test study for early cancer detection in patients
This study collects blood from people with cancer and people without cancer (or with possible cancer) to test whether new blood tests can detect cancer earlier. Your blood samples help researchers evaluate how well these tests work.
Jamaica Plain, MassachusettsAges 40–75 - NCT03851445RecruitingPhase 2/Phase 3
Lung cancer screening trial using tumor and blood test results
This trial helps sort people with previously treated lung cancer into the best next treatment options by using new tumor tissue (and sometimes blood) test results. It may help you get matched to therapies based on features like PD-L1 and other biomarkers.
Jamaica Plain, MassachusettsAges 18 years+ - NCT04185935Recruiting
Genetic study of cancer in patients and their families
This study looks at DNA patterns in families where cancer may run in families, to better understand inherited (passed-down) cancer risk. You may be able to help even if you’re not sure whether your cancer is genetic—your family history and, if needed, medical records or tumor samples can be used.
Brighton, MassachusettsAges Any age
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Cancer trials in other cities
Where these studies are running near Boston
Institutions with a site for the recruiting cancer studies listed above.
- Dana-Farber Cancer Institute · 11 studies
- Massachusetts General Hospital Cancer Center · 4 studies
- Brigham and Women's Hospital · 3 studies
- Massachusetts General Hospital · 3 studies
- Beth Israel Deaconess Medical Center · 2 studies
- Boston Veteran's Affairs Medical Center · 2 studies
- Lahey Hospital and Medical Center · 2 studies
- Lahey Medical Center Peabody · 2 studies
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting cancer studies in Massachusetts.
Common questions
- Are there cancer clinical trials near Boston?
- Yes. We're currently tracking 800 recruiting cancer studies with a site near Boston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study near Boston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Boston to take part?
- Not necessarily. These studies have a site near Boston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open near Boston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.