Clinical trials
Cannabis Use Disorder, Moderate clinical trials
Below are recruiting cannabis use disorder, moderate clinical trials, each written for real people, not researchers. We’re tracking 61 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07464613Recruiting
Social thinking in severe alcohol use disorder
This study looks at how people with severe alcohol use disorder process social information, like understanding others' emotions or intentions. It uses brain imaging (MRI) and tests on a smartphone. The goal is to learn more about social cognition in recovery.
Reims, ReimsAges 18–65 - NCT07490600Recruiting
Testing brain stimulation and rewards for quitting cocaine
This trial combines deep transcranial magnetic stimulation (TMS) with a reward program (contingency management) to help people stop using cocaine. It may help if you are struggling with moderate to severe cocaine use and want a non-drug treatment.
Houston, TexasAges 18–65 - NCT07520292RecruitingPhase 1
Testing NTX-2001 to reduce drinking in alcohol use disorder
This study tests whether a new medication called NTX-2001 can help people with alcohol use disorder drink less. Researchers will measure how the drug affects alcohol consumption and safety in adults aged 21–60.
New Haven, ConnecticutAges 21–60 - NCT07612631RecruitingEarly Phase 1
Brain imaging study of alcohol and stress response
This research uses brain imaging to understand how two brain systems—one involved in stress and one involved in reward—interact in people with alcohol use disorder. The goal is to find new ways to help people reduce heavy drinking.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07559500RecruitingPhase 1
Study of tirzepatide for alcohol use disorder
This trial tests if tirzepatide, a diabetes drug, affects brain chemistry linked to alcohol use. Researchers want to see if it can help people with mild-to-moderate alcohol use disorder who also have tried stimulants.
Bethesda, MarylandAges 21–65 - NCT06648642Recruiting
MRI-guided brain stimulation for alcohol use disorder
This study tests whether a new type of brain stimulation, guided by MRI and a robot, can help reduce heavy drinking in people with alcohol use disorder. The treatment is non-invasive and aims to improve brain function related to cravings.
San Antonio, TexasAges 18–65 - NCT07684976Recruiting
Safety of a helmet device using ultrasound for substance use disorder
This study tests a special helmet that uses focused ultrasound to stimulate parts of the brain involved in addiction. It aims to see if the treatment is safe and works for people with moderate to severe substance use disorder who have not gotten enough help from standard medication treatments.
Toronto, OntarioAges 18–70 - NCT06430580RecruitingEarly Phase 1
Cannabinoids and stress response in heavy cannabis users
This early-phase study tests how cannabinoids affect your body's reaction to stress. If you use cannabis daily and have cannabis use disorder, you may be able to join to help researchers understand these effects better.
Tallahassee, FloridaAges 18–50 - NCT06784908Recruiting
Stress and pain study for people living with HIV
This study looks at how stress affects pain in people with HIV. It may help find better ways to manage pain in this group.
New Haven, ConnecticutAges 18–68 - NCT04935619Recruiting
Testing cannabis abstinence effects in depression symptoms
This study looks at how stopping cannabis for a period of time may affect depression symptoms and thinking/memory. You might benefit by getting close monitoring of mood and cognition while researchers compare changes during cannabis abstinence.
Toronto, OntarioAges 18–55 - NCT06484075RecruitingPhase 1/Phase 2
Suvorexant for alcohol use disorder: brain effects
This study tests whether the sleep medication suvorexant can help people with alcohol use disorder by looking at its effects on brain activity. Participants will stay in the hospital for about a month, take suvorexant or a placebo, and have brain scans.
Bethesda, MarylandAges 18–75 - NCT07214207RecruitingPhase 2
Testing a sleep medicine for alcohol use disorder and stress-related drinking
This trial tests whether a medicine called suvorexant, which is used for sleep, can help people with alcohol use disorder drink less, especially when stressed. You would receive the medicine or a placebo, and researchers will track your drinking and stress levels over several weeks.
Columbus, OhioAges 18–65 - NCT06030154Recruiting
Boosting positive feelings for people with alcohol use disorder
This study tests a program designed to help people with alcohol use disorder who also struggle with low mood or anxiety. It aims to increase positive emotions, which may make it easier to reduce drinking.
Tulsa, OklahomaAges 18–65 - NCT06218056RecruitingPhase 2
CBD for reducing cigarette smoking in a treatment center
This study tests whether a daily dose of cannabidiol (CBD) can help people who smoke at least 5 cigarettes a day cut down or quit. It is for people staying at a treatment center in Los Angeles where cannabis use is not allowed.
North Hollywood, CaliforniaAges 18–65 - NCT06379984RecruitingPhase 2
Quick-start buprenorphine for opioid addiction with fentanyl use
This trial tests a way to quickly start buprenorphine (a medication for opioid addiction) in an outpatient clinic for people who use fentanyl. It aims to make starting treatment easier and faster, without needing to go through full withdrawal first.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05838274Recruiting
Study of alcohol effects and brain scans in bipolar disorder
This study gives a controlled amount of alcohol and uses brain MRI scans to understand how alcohol affects people with bipolar disorder. It may help researchers find brain and behavior patterns that explain differences in alcohol responses.
Austin, TexasAges 21–26 - NCT06743373Recruiting
Cannabis and sleep in young adults
This study looks at how cannabis affects sleep, daily rhythms, and sensitivity to light in young adults. You would either stop using cannabis for 4 weeks (if you are a regular user) or serve as a non-user control, to compare sleep patterns.
Pittsburgh, PennsylvaniaAges 18–25 - NCT05219175RecruitingPhase 2
MDMA therapy for PTSD and opioid addiction after childbirth
This Phase 2 study tests whether MDMA-assisted therapy can reduce symptoms of PTSD and help with opioid use disorder in people after childbirth. You must be on a stable, low enough dose of methadone or buprenorphine and be able to follow study rules, including therapy sessions and safety monitoring.
Albuquerque, New MexicoAges 18 years+ - NCT06636227RecruitingPhase 1
Diclofenac dose study for alcohol use disorder
This study tests whether different doses of diclofenac, an anti-inflammatory drug, can help people reduce heavy drinking. It looks at how the drug affects drinking patterns and overall health.
Catonsville, MarylandAges 21–65 - NCT04793685RecruitingPhase 2
Prazosin for alcohol withdrawal symptoms in alcohol use disorder
This study tests whether prazosin can reduce symptoms that happen when someone stops or cuts back on heavy drinking. It may help people with moderate-to-severe alcohol use disorder who also have alcohol withdrawal symptoms.
New Haven, ConnecticutAges 18–70 - NCT04883255RecruitingEarly Phase 1
Study cannabis effects on brain function in adults with HIV
This early-phase study looks at how cannabis (and the body’s cannabinoid system) may affect thinking and brain-related measures in people with HIV. You may be asked to avoid cannabis and complete several brain and health assessments to see how these factors relate.
San Diego, CaliforniaAges 18–65 - NCT05008146RecruitingEarly Phase 1
Brain imaging study for cocaine use disorder interactions
This early-phase study uses brain imaging to understand how cocaine use disorder affects brain function. It may help researchers learn more about brain pathways involved in craving and treatment targets.
Pittsburgh, PennsylvaniaAges 18–55 - NCT05929677RecruitingEarly Phase 1
Study tests effects on impulsivity and how alcohol feels
This early-phase study looks at how alcohol affects impulsivity (tendency to act quickly) and people’s subjective experiences. You may be able to join if you drink regularly and meet the study safety rules.
Boston, MassachusettsAges 21–25 - NCT06125054RecruitingPhase 2
Ketamine and brain training for cocaine addiction
This trial tests whether a combination of ketamine (a medicine that may help the brain change) and neurofeedback training (a brain-exercise technique) can help people with cocaine addiction. The goal is to see if these treatments can improve brain flexibility and reduce cravings.
Zurich, Canton of ZurichAges 18–55
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Common questions
- Are there clinical trials for cannabis use disorder, moderate?
- Yes. Clin2 currently lists 61 recruiting cannabis use disorder, moderate studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cannabis use disorder, moderate trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cannabis use disorder, moderate trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.