Clinical trials
Cannabis Use Disorder, Severe clinical trials
Below are recruiting cannabis use disorder, severe clinical trials, each written for real people, not researchers. We’re tracking 93 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06941298Recruiting
Cannabis and depression study for teens and young adults
This study looks at how cannabis affects the brain and mood in teens and young adults. It compares people who use cannabis, people with depression who don't use cannabis, and healthy volunteers to understand links between cannabis use and mental health.
Miami, FloridaAges 14–20 - NCT06648642Recruiting
MRI-guided brain stimulation for alcohol use disorder
This study tests whether a new type of brain stimulation, guided by MRI and a robot, can help reduce heavy drinking in people with alcohol use disorder. The treatment is non-invasive and aims to improve brain function related to cravings.
San Antonio, TexasAges 18–65 - NCT07459270Recruiting
Psychotic symptoms in methamphetamine users with and without cannabis
This study compares people who have psychosis from methamphetamine and also use cannabis with those who only have methamphetamine-induced psychosis. It aims to understand how cannabis may affect their symptoms.
Elâzığ, ElâzığAges 18–65 - NCT06784908Recruiting
Stress and pain study for people living with HIV
This study looks at how stress affects pain in people with HIV. It may help find better ways to manage pain in this group.
New Haven, ConnecticutAges 18–68 - NCT05985850RecruitingPhase 2
Can cannabis help with opioid addiction treatment?
This trial tests if adding a specific cannabis product to standard methadone treatment helps people with opioid use disorder. It's for adults over 25 who recently started methadone and have used cannabis before.
Vancouver, British ColumbiaAges 25 years+ - NCT05860699RecruitingPhase 2
Cannabidiol added during inpatient alcohol withdrawal
This trial tests whether cannabidiol (CBD) given during an inpatient alcohol detox helps people stay off alcohol afterward. You would be compared with standard care to see if CBD improves recovery during and after withdrawal.
Créteil, Albert ChenevierAges 18–75 - NCT04935619Recruiting
Testing cannabis abstinence effects in depression symptoms
This study looks at how stopping cannabis for a period of time may affect depression symptoms and thinking/memory. You might benefit by getting close monitoring of mood and cognition while researchers compare changes during cannabis abstinence.
Toronto, OntarioAges 18–55 - NCT07214207RecruitingPhase 2
Testing a sleep medicine for alcohol use disorder and stress-related drinking
This trial tests whether a medicine called suvorexant, which is used for sleep, can help people with alcohol use disorder drink less, especially when stressed. You would receive the medicine or a placebo, and researchers will track your drinking and stress levels over several weeks.
Columbus, OhioAges 18–65 - NCT06484075RecruitingPhase 1/Phase 2
Sleep medication for alcohol use disorder
This study tests whether suvorexant, a sleep aid, can help people with alcohol use disorder by looking at brain changes. It may improve sleep and reduce drinking.
Bethesda, MarylandAges 18–75 - NCT07773649RecruitingEarly Phase 1
PET scan to study energy use in brain of people with cocaine use disorder
This study uses a special PET scan to look at how brain cells make energy, which may be changed by cocaine. It might help researchers find better ways to treat cocaine use disorder.
Pittsburgh, PennsylvaniaAges 18–45 - NCT07732062Recruiting
Emotion-focused therapy for chronic pain patients using medical cannabis
This study tests a new type of talking therapy (vEAET-H) to see if it helps people with chronic pain who are already using medical cannabis. The goal is to find out if adding this therapy can improve pain and well-being.
Tel AvivAges 18 years+ - NCT06104280Recruiting
How opioid addiction meds affect sleep and eyes
This study tests how three common medications for opioid use disorder (methadone, buprenorphine, and naltrexone) affect eye function, sleep, and daily body rhythms. It may help find ways to improve treatment for opioid addiction.
Birmingham, AlabamaAges 18–80 - NCT01730781Recruiting
PET scan study to image cannabinoid receptors in the brain
This study uses a special brain scan (PET) to measure cannabinoid receptors—areas in the brain that interact with cannabis-like chemicals. It may help researchers better understand how these receptors relate to conditions such as schizophrenia, PTSD, opioid use disorder, or early psychosis risk.
New Haven, ConnecticutAges 18–55 - NCT06379984RecruitingPhase 2
Quick-start buprenorphine for opioid addiction with fentanyl use
This trial tests a way to quickly start buprenorphine (a medication for opioid addiction) in an outpatient clinic for people who use fentanyl. It aims to make starting treatment easier and faster, without needing to go through full withdrawal first.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05838274Recruiting
Study of alcohol effects and brain scans in bipolar disorder
This study gives a controlled amount of alcohol and uses brain MRI scans to understand how alcohol affects people with bipolar disorder. It may help researchers find brain and behavior patterns that explain differences in alcohol responses.
Austin, TexasAges 21–26 - NCT06743373Recruiting
Cannabis and sleep in young adults
This study looks at how cannabis affects sleep, daily rhythms, and sensitivity to light in young adults. You would either stop using cannabis for 4 weeks (if you are a regular user) or serve as a non-user control, to compare sleep patterns.
Pittsburgh, PennsylvaniaAges 18–25 - NCT05786157Recruiting
Couples alcohol and safety support for drinking and relationship harm
This study tests a patient-focused approach to help couples where alcohol misuse and relationship physical harm may be happening. You may be asked to take part in sessions focused on safety, coping, and relationship communication, and some components may include controlled alcohol exposure.
Charleston, South CarolinaAges 21 years+ - NCT05219175RecruitingPhase 2
MDMA therapy for PTSD and opioid addiction after childbirth
This Phase 2 study tests whether MDMA-assisted therapy can reduce symptoms of PTSD and help with opioid use disorder in people after childbirth. You must be on a stable, low enough dose of methadone or buprenorphine and be able to follow study rules, including therapy sessions and safety monitoring.
Albuquerque, New MexicoAges 18 years+ - NCT07296874RecruitingPhase 2
Cannabis and thinking: a study of mood and memory
This study looks at how cannabis affects thinking and mood. If you join, you'll have a session where you use cannabis and then do some thinking and mood tasks, to see how it affects you.
Pullman, WashingtonAges 21 years+ - NCT07477990RecruitingPhase 3
Testing a digital device for anxiety treatment
This trial is testing a digital device called Aurora that helps treat moderate to severe anxiety. It compares the device to standard anxiety medications, so you may receive either the device or a pill. The goal is to see if the device can work as well as medication without the side effects.
Mexico City, Mexico CityAges 18–65 - NCT04084860RecruitingPhase 2
Brief medicine trial to help reduce heavy alcohol drinking
This Phase 2 study tests a brief medication approach meant to reduce “problem drinking.” It may help people cut back or stop alcohol use by adjusting brain signaling related to drinking cravings and urges.
New York, New YorkAges 21–70 - NCT07812753Recruiting
Brain stimulation for smoking cessation
This study looks at how a non-invasive brain stimulation technique called TMS (which uses magnetic pulses to stimulate the brain) might affect the brain's reward system in people who smoke. The goal is to understand how to help people quit smoking more effectively.
Newark, New JerseyAges 18–60 - NCT07713251Recruiting
Computer skills training for teens seeking alcohol help
This study tests a computer-based program called Path180 to help teenagers ages 13-19 reduce their alcohol use. If you are already seeing a counselor or in treatment for alcohol or mental health, this program might add extra support.
Providence, Rhode IslandAges 13–19 - NCT07595614Recruiting
Weekly Writing to Track Recovery Progress in Substance Use
This study asks men in residential treatment for substance use to write weekly reflections about their recovery. Researchers will analyze these writings to better understand how people progress through treatment and improve how clinicians support recovery.
Potrerillos, JaliscoAges 18 years+
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Common questions
- Are there clinical trials for cannabis use disorder, severe?
- Yes. Clin2 currently lists 93 recruiting cannabis use disorder, severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cannabis use disorder, severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cannabis use disorder, severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.