Clinical trials · Philadelphia, PA
Cardiovascular Diseases clinical trials in Philadelphia
We’re tracking 26 recruiting cardiovascular diseases studies with a site in or near Philadelphia — including Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Philadelphia
- NCT07064473RecruitingPhase 3
Testing vicadrostat plus empagliflozin for diabetes, high blood pressure, and heart disease
This study tests a new pill called vicadrostat taken with another medicine (empagliflozin) to see if it helps people with type 2 diabetes, high blood pressure, and heart disease. It may reduce the risk of heart problems, but you must not have had heart failure or use certain other heart medications.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07517263RecruitingPhase 3
Long-term Safety Study of Pelacarsen Treatment
This study follows patients who completed an earlier pelacarsen trial to check if the treatment remains safe and well-tolerated over time. Pelacarsen is an experimental medicine being tested for heart and cholesterol health.
Philadelphia, PennsylvaniaAges 18–100 - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Philadelphia, PennsylvaniaAges 18 years+ - NCT01524276Recruiting
Registry to track outcomes of Medtronic medical devices
This is a follow-up registry that collects information from people who have (or will receive) an eligible Medtronic device. It helps the company and doctors better understand how the device works in real-world use.
Philadelphia, PennsylvaniaAges Any age - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04262206RecruitingPhase 4
Testing how statins affect outcomes in adults 75 and older
This trial studies whether cholesterol-lowering medicine (a statin, specifically atorvastatin) improves health and benefits in people age 75 and older in everyday life. It may help doctors understand which older adults benefit most and how to use these medicines safely.
Philadelphia, PennsylvaniaAges 75 years+ - NCT05472597Enrolling by invitation
Follow-up study about heart health after pregnancy
This study is continuing follow-up interviews and surveys to learn about heart health after pregnancy. If you already took part before, it may help researchers understand how postpartum health changes over time.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06542432Enrolling by invitation
Genetic risk test for heart disease prevention
This trial uses a polygenic risk score to see if knowing your genetic risk for coronary artery disease can help prevent a first heart attack. If you have an intermediate 10-year risk and no prior heart events, you may be eligible.
Philadelphia, PennsylvaniaAges 40–70 - NCT05390892RecruitingPhase 4
Preventing kidney and heart damage in type 2 diabetes
This study tests whether diabetes medicines can help prevent worsening heart and kidney problems in people with type 2 diabetes. You’ll be assigned by chance to one of these medicine types, and your other care will be adjusted for safety.
Philadelphia, PennsylvaniaAges 40–80 - NCT07136012RecruitingPhase 3
Olpasiran trial to lower Lp(a) and prevent first heart attack or stroke
This trial tests if olpasiran can lower a type of cholesterol called Lp(a) to help prevent a first major heart attack, stroke, or other heart problems. It is for people at higher risk due to risk factors or early signs of artery disease, but who have not yet had a heart attack or stroke.
Philadelphia, PennsylvaniaAges 50–105 - NCT04545502Recruiting
Study of aortic grafts and heart patches after aortic surgery
This study looks at how well certain aortic grafts and cardiovascular patches work after surgery. It may help by improving care for people who need these devices, and by collecting safety and outcome information over time.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07000357RecruitingPhase 3
Study of AZD0780 to reduce heart attack and stroke risk
This trial tests a new medication, AZD0780, to see if it helps prevent major cardiovascular events like heart attacks or strokes in people who already have heart or blood vessel disease, or are at high risk for a first event. It might be a good fit if your cholesterol isn't well-controlled despite current treatments.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06732102Recruiting
Philly Heart Health Study: DECIDE+
This study tests a program to help Philadelphians with conditions like high blood pressure, diabetes, or weight concerns and unmet social needs (like food or housing) get better health support. You'll work with a community health worker to learn ways to improve your health.
Philadelphia, PennsylvaniaAges 35–75 - NCT06870591Recruiting
Heart measurement device study
This trial tests a new device that measures heart function without needing an invasive catheter. It aims to see if the device works as well as the standard right heart catheterization procedure.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07293260RecruitingPhase 3
Olpasiran heart scan study for high Lp(a) patients
This study tests if a medication called olpasiran can lower a type of fat in your blood called Lp(a), which is linked to heart problems. You take the medicine or a placebo and get a special heart scan to see changes in your arteries.
Philadelphia, PennsylvaniaAges 35–80 - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Philadelphia, PennsylvaniaAges 18–100 - NCT07157774RecruitingPhase 3
Muvalaplin for heart disease in people with high lipoprotein(a)
This study tests a new medicine called muvalaplin that lowers a specific type of cholesterol linked to heart disease. It aims to see if muvalaplin can reduce the risk of future heart attacks, strokes, or related procedures in people with high levels of this cholesterol.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07181109RecruitingPhase 3
Study of zilebesiran for high-risk hypertension patients
This trial tests a new medicine called zilebesiran for people with high blood pressure that isn't well controlled. It may be an option if you have heart or blood vessel disease, or are at high risk for it.
Philadelphia, PennsylvaniaAges 18 years+ - NCT03683186Enrolling by invitationPhase 3
Long-term study of ralinepag for pulmonary hypertension
This study follows people with pulmonary arterial hypertension (PAH) to see how safe and effective ralinepag is over the long term. It may help your care team understand what to expect from continued treatment and monitoring.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06907147Recruiting
Renal denervation for uncontrolled high blood pressure
This trial tests a procedure called renal denervation to lower blood pressure in people whose medication isn't enough. It uses a special catheter to calm nerves near the kidneys that may be overactive.
Camden, New JerseyAges 18–80 - NCT06742723RecruitingPhase 3
Study of baxdrostat and dapagliflozin for kidney disease and high blood pressure
This trial tests if combining baxdrostat with dapagliflozin helps protect kidney function and reduce heart risks in people with chronic kidney disease and high blood pressure. It's for adults who are already taking standard blood pressure medications.
Media, PennsylvaniaAges 18 years+ - NCT06297291Recruiting
Long-term safety study for a kidney nerve treatment
This study tests a device that uses ultrasound to calm overactive kidney nerves, which may help lower blood pressure. It is for people with high blood pressure that is hard to control with medication.
Marlton, New JerseyAges 18 years+ - NCT07037433RecruitingPhase 3
Heart protection study for people with heart disease and overweight
This study tests a new weekly injection (maridebart cafraglutide) to see if it helps lower the risk of heart problems in people with heart disease and overweight. It is for adults who have had a heart attack, stroke, or artery blockages and also have a BMI of 27 or higher.
Horsham, PennsylvaniaAges 45–99 - NCT06875973RecruitingPhase 3
Pelacarsen long-term extension study
This trial is for people who have already finished taking pelacarsen in a previous study. It offers continued access to the drug and checks long-term safety.
Linwood, PennsylvaniaAges 18–100
Hear when a new Cardiovascular Diseases trial opens near Philadelphia, PA
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Cardiovascular Diseases trials in other cities
Where these studies are running near Philadelphia
Institutions with a site for the recruiting cardiovascular diseases studies listed above.
- University of Pennsylvania · 11 studies
- Thomas Jefferson University Hospital · 5 studies
- Cardiology Consultants of Philadelphia · 3 studies
- Lehigh Valley Hospital-Cedar Crest · 2 studies
- Research Site · 2 studies
- Virtua Health · 2 studies
- Abington Medical Specialists
- Abington Memorial Hospital
What taking part in a cardiovascular diseases study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting cardiovascular diseases studies in Pennsylvania.
Common questions
- Are there cardiovascular diseases clinical trials near Philadelphia?
- Yes. We're currently tracking 26 recruiting cardiovascular diseases studies with a site near Philadelphia, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cardiovascular diseases study near Philadelphia?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Philadelphia to take part?
- Not necessarily. These studies have a site near Philadelphia, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cardiovascular diseases trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cardiovascular diseases studies open near Philadelphia regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.