Clinical trials
Chemotherapy clinical trials
Below are recruiting chemotherapy clinical trials, each written for real people, not researchers. We’re tracking 1,990 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06435429RecruitingPhase 3
Zanidatamab vs trastuzumab for HER2+ breast cancer
This study compares a new drug called zanidatamab against trastuzumab (Herceptin), both given with a chemotherapy of your doctor's choice. It is for people with HER2-positive breast cancer that has spread and who have already tried T-DXd treatment.
Phoenix, ArizonaAges 18 years+ - NCT05751044RecruitingPhase 1/Phase 2
Study of four medicines for children with difficult blood cancers
This Phase 1/2 trial tests a combination of medicines (dasatinib, venetoclax, dexamethasone, cyclophosphamide, and cytarabine) in children and teens whose blood cancer has come back or did not respond to treatment. It aims to see whether this approach can control the cancer while checking what doses are safe.
ViennaAges 1–21 - NCT05745714RecruitingPhase 1/Phase 2
Targeted triple-combination treatment for children with relapsed blood cancers
This Phase 1/2 study tests a multi-drug combination (ruxolitinib, venetoclax, dexamethasone, plus chemotherapy) for children whose blood cancer has come back or did not respond. It aims to reduce the cancer by targeting specific genetic changes and may offer a new option when standard treatments have not worked.
ViennaAges 1–21 - NCT06409767Recruiting
Early warning system for blood cancer patients on chemo or transplant
This study tests whether a special early warning system can help doctors spot problems sooner in people with blood cancers who are getting strong chemo or a stem cell transplant. The goal is to improve outcomes by catching complications early.
AmiensAges 18 years+ - NCT06417814RecruitingPhase 3
Study of Dato-DXd with or without osimertinib for EGFR-mutated lung cancer
This trial tests a new drug, Dato-DXd, given alone or with osimertinib, versus standard chemotherapy for people with a specific type of advanced lung cancer (EGFR-mutated non-small cell lung cancer) that has worsened after osimertinib treatment.
Fayetteville, ArkansasAges 18–130 - NCT06408116RecruitingPhase 2
FAPI-PET Scan for Esophageal Cancer Surgery Planning
This trial tests whether a special PET scan called FAPI-PET can better show the edges of esophageal tumors before surgery. It may help doctors plan more precise surgery.
HeidelbergAges 18 years+ - NCT06417190RecruitingPhase 2
Bladder preservation trial for muscle-invasive bladder cancer with variant histology
This trial tests a bladder-sparing approach for people with muscle-invasive bladder cancer that has a variant histology type. The goal is to avoid removing the bladder by using a combination of treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT06387121RecruitingPhase 2
Low-dose chemo plus immune drugs for new B-ALL
This trial tests a combination of low-dose chemotherapy and immune-targeted drugs for adults newly diagnosed with a specific type of leukemia. The goal is to find a treatment that is effective with fewer side effects.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06027632Recruiting
Brain training at home to help with chemo brain after breast cancer treatment
This study tests a supervised computer-based mental exercise program to help reduce memory and thinking problems after chemotherapy. It is for people who finished chemo for early-stage breast cancer and still have bothersome mental fogginess.
BordeauxAges 1.5 years+ - NCT06370416Enrolling by invitationPhase 2
Preventing bone marrow suppression from chemo in advanced lung cancer
This trial tests if trilaciclib can protect your bone marrow during chemotherapy for advanced non-small cell lung cancer. The goal is to reduce side effects like low blood counts, which can cause fatigue, infections, or bleeding.
Zhengzhou, HenanAges 18 years+ - NCT06368141RecruitingPhase 2
Chemo plus immunotherapy before surgery for colon cancer
This trial tests whether giving chemotherapy followed by an immunotherapy drug (a checkpoint inhibitor) before surgery helps shrink locally advanced colon cancer. It is for people with a specific tumor type (MSS and RAS mutation) who have not had prior treatment.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06376162RecruitingPhase 1
Ziftomenib with chemotherapy for children with relapsed leukemia
This trial tests whether adding a new drug called ziftomenib to standard chemotherapy can help children whose leukemia has come back or not responded to treatment. It is for children with certain genetic changes in their leukemia cells.
Los Angeles, CaliforniaAges birth–21 years - NCT03396718Recruiting
De-escalating radiation after HPV head and neck cancer surgery
This study looks at whether some people with HPV-positive throat/oropharynx cancer can safely receive a less intense form of radiation (and sometimes chemo) after surgery. It aims to reduce treatment burden while keeping the cancer under control, based on how high-risk the pathology looks.
Tübingen, Baden-WurttembergAges 18 years+ - NCT06340568RecruitingPhase 3
Study of an experimental drug vs. chemo for recurring uterine cancer
This trial is testing an experimental therapy against standard chemotherapy for people with endometrial cancer that has come back. The study looks for a certain protein (HER2) on cancer cells to decide which treatment group you may be in.
New Haven, ConnecticutAges 18 years+ - NCT05184582Recruiting
Exercise program during chemotherapy for breast cancer
This trial studies whether a structured exercise program during pre-surgery chemotherapy can be safely done and may help people feel and function better during treatment. You may join if you have invasive breast cancer and can commit to the exercise plan while on chemotherapy.
MelbourneAges 18–100 - NCT06342284Recruiting
Collecting health data during radiation for lung cancer
This trial asks people getting radiation therapy for lung cancer to use a wearable device and smartphone app to track their activity and symptoms. The goal is to learn how this treatment affects patients day-to-day.
New York, New YorkAges 18 years+ - NCT06339658Recruiting
Comparing two dyes for lymph node surgery in breast cancer
This trial compares two dyes (ICG and blue patent) to see which is better for finding the first lymph node (sentinel node) during surgery in women with breast cancer that has spread to the lymph nodes and who had chemotherapy first.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT05305131RecruitingPhase 2
Testing chemotherapy with or without extra cancer medicines for nasopharyngeal cancer
This Phase 2 study compares standard chemotherapy (gemcitabine plus cisplatin) against the same chemotherapy plus pembrolizumab and bevacizumab. It aims to see which combination works better for EBV-positive nasopharyngeal cancer before any prior treatment.
SingaporeAges 1.8 years–99 years - NCT06333899RecruitingEarly Phase 1
Lorlatinib for newly diagnosed brain tumors with ROS or ALK fusion
This trial tests if lorlatinib, a targeted pill, can shrink or slow the growth of high-grade brain tumors that have a specific ROS or ALK genetic change. It is for children and young adults who have not yet had treatment for their tumor.
Aurora, ColoradoAges 1–21 - NCT06333314RecruitingPhase 2
Dostarlimab for advanced dMMR/MSI cancers (not colorectal or endometrial)
This trial tests a drug called dostarlimab for people with certain advanced cancers that have a specific genetic feature (dMMR/MSI-H). The goal is to see if it helps shrink or control the cancer in people who haven't had other treatments yet.
AngersAges 18 years+ - NCT06323239RecruitingPhase 2
Radiation plus chemo and immunotherapy for advanced nasopharyngeal cancer
This trial tests a combination of two types of radiation therapy (standard SBRT and low-dose radiation) along with chemotherapy and an immunotherapy drug (PD-1 antibody) for people whose nasopharyngeal cancer has come back or spread. The goal is to see if this combination can better control the cancer.
Guangzhou, GuangdongAges 18–75 - NCT06317662RecruitingPhase 2
Adding venetoclax and blinatumomab to chemo for infant leukemia
This trial tests adding two newer medicines (venetoclax and blinatumomab) to standard chemotherapy for infants with a specific type of leukemia. The goal is to see if this combination helps more babies stay cancer-free.
Birmingham, AlabamaAges Up to 12 months - NCT06314334RecruitingPhase 2
Chemotherapy plus radiation for early-stage NK/T-cell lymphoma
This trial tests whether combining chemotherapy with radiation therapy can work well for people with early-stage NK/T-cell lymphoma that started in the nose or throat. It aims to find a more effective treatment approach with fewer side effects.
Fuzhou, FujianAges 18–75 - NCT06313203RecruitingPhase 2
Chemotherapy with or without liver-directed treatment for bile duct cancer
This trial tests whether adding a liver-directed treatment (HAI floxuridine or SIRT) to standard chemotherapy (GemOx) is more effective for people with bile duct cancer inside the liver that cannot be removed by surgery. It may be an option for those whose cancer is only in the liver or nearby lymph nodes.
Oslo, OsloAges 18 years+
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Common questions
- Are there clinical trials for chemotherapy?
- Yes. Clin2 currently lists 1,990 recruiting chemotherapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chemotherapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chemotherapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.