Clinical trials
Chronic Back Pain clinical trials
Below are recruiting chronic back pain clinical trials, each written for real people, not researchers. We’re tracking 329 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06977958Enrolling by invitation
Gluteal enhancement trial for non-active women
This trial tests a program called NASM OPT to see if it can improve hip appearance in women who haven't exercised for the last 6 months. It might help you if you're looking to reshape your hips safely.
Ferdows, South Khorasan ProvinceAges 20–45 - NCT06860867Recruiting
Nucleus replacement for single-level discogenic low back pain
This trial tests a new device called PerQdisc for people with chronic low back pain from a single damaged disc in the lower spine. The goal is to see if the device can safely replace the inner gel of the disc without major surgery.
Glendale, ArizonaAges 22–70 - NCT06297200Recruiting
Ultrasound treatment for complex back pain patients
This study tests a new, non-invasive ultrasound treatment for people with long-term back pain who also have opioid use disorder and anxiety. It aims to see if this gentle brain stimulation can reduce pain and improve quality of life.
Roanoke, VirginiaAges 18–65 - NCT05851976RecruitingPhase 4
Duloxetine for short-term non-radiating low back pain
This trial tests duloxetine (a medicine used for certain pain conditions and mood) for easing low back pain that started recently and doesn’t shoot down your leg. It may help reduce pain and improve daily function after an ER visit, but you must meet several safety and medication-use criteria.
The Bronx, New YorkAges 18–64 - NCT05585229RecruitingPhase 2
Psilocybin therapy to help you taper opioid pain medicine
This Phase 2 study tests a structured, therapist-led treatment using standardized natural psilocybin to help people reduce or stop long-term opioid use for chronic (non-cancer) pain. It’s mainly for those who have tried tapering before but couldn’t, and who are motivated to try again.
Kelowna, British ColumbiaAges 19–75 - NCT05661903RecruitingPhase 2
Spinal cord stimulator study for nerve pain and brain effects
This Phase 2 study looks at how spinal cord (or nerve-root) stimulation affects pain signals in the brain and body. You may qualify if you already have a stimulator set to a comfort mode that avoids “tingling” sensations.
Boston, MassachusettsAges 18–80 - NCT05556902Recruiting
Testing how epidural spinal cord stimulation may help chronic pain
This study looks at how a device that sends mild signals to the area around your spinal cord may work for long-lasting (chronic) pain. You may be asked to visit a research lab, have blood taken, and follow the study plan so researchers can understand the treatment’s effects.
Birmingham, AlabamaAges 18–89 - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT04381208Recruiting
Using health and movement data to diagnose sacroiliac pain
This study looks at medical records and physical/neurological exam findings to help diagnose sacroiliac joint dysfunction, a common source of chronic low back or buttock pain. It may help your care team better sort out what’s causing your pain and choose the right next steps.
Valencia, ValenciaAges 18 years+ - NCT07217821Recruiting
Music and imagery for chronic pain
This study tests a step-by-step approach using music and guided imagery to help people with long-term muscle or joint pain. It's done from home using a device, so you don't need to travel.
Indianapolis, IndianaAges 18 years+ - NCT06977100Recruiting
Journaling study for jaw pain with other chronic pain conditions
This study tests if a journaling program can help people with jaw pain and at least one other chronic pain condition (like fibromyalgia, IBS, or migraines). You will write about your thoughts and feelings to see if it reduces pain and improves well-being.
Gainesville, FloridaAges 18–80 - NCT06543979RecruitingPhase 1/Phase 2
Anorectal manometry for children with chronic constipation
This study is for children aged 4–16 who have long-term constipation that doesn't get better with standard laxatives. It uses a test called anorectal manometry to measure how well the muscles in the bottom work, which can help guide treatment.
CairoAges 4–16 - NCT05421273Recruiting
Testing two spinal stimulation patterns for long-term back pain
This study compares two ways of delivering spinal cord stimulation to see which better reduces pain in people with persistent spinal pain syndrome type 2. You would be assigned to one of the stimulation “burst” patterns and followed for changes in your pain experience.
Arnhem, GelderlandAges 18–70 - NCT06264297Recruiting
Nerve radiofrequency treatment for chronic leg pain
This trial tests a new type of treatment (high-voltage pulsed radiofrequency) that uses a special needle to deliver energy to the nerve root in your lower back. The goal is to see if it can reduce chronic leg pain caused by a pinched or irritated nerve.
Terrassa, BarcelonaAges 18 years+ - NCT07211308Recruiting
A study of spinal cord stimulation for chronic leg pain
This trial tests a type of spinal cord stimulation (DTM SCS) for people with chronic leg or foot pain caused by nerve damage (PSPS-T2). It aims to see if this treatment can safely reduce pain and improve daily life.
BrusselsAges Any age - NCT05269212Recruiting
Help people with ongoing back pain return to work
This study looks at how to help people with long-lasting spinal pain (PSPS-Type II) get back to work. It may help by testing a plan for managing persistent pain so work becomes more doable.
GhentAges 18–60 - NCT07830836Enrolling by invitation
Physiotherapy and osteopathy for recent neck, back, or jaw pain
This study tests whether physiotherapy and osteopathic treatment can help relieve recent (acute) pain in the neck, lower back, or jaw joint. It aims to understand if these hands-on therapies reduce pain and improve jaw function.
Gorzów Wielkopolski, Lubusz VoivodeshipAges 20–40
Hear when a new Chronic Back Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for chronic back pain?
- Yes. Clin2 currently lists 329 recruiting chronic back pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic back pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic back pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.