Clinical trials
Chronic Back Pain clinical trials
Below are recruiting chronic back pain clinical trials, each written for real people, not researchers. We’re tracking 331 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05853640Recruiting
Education and exercise for long-term hip or groin pain
This trial tests whether a program of education plus exercise can reduce long-term hip or groin pain. It may help by improving movement and function, especially when pain has lasted more than 3 months.
MalmöAges 18–55 - NCT07433634Recruiting
Tracking recovery after BVN ablation for chronic low back pain
This study looks at how well a procedure called BVN ablation (which uses heat to stop pain signals from the vertebrae) works for people with chronic low back pain that comes from the spine. If you already have this procedure scheduled, researchers will track your recovery and pain relief over time.
Guilford, ConnecticutAges 18 years+ - NCT07507422Recruiting
Post-market study of Inceptiv spinal cord stimulation
This study follows people receiving Inceptiv, a spinal cord stimulator from Medtronic, to see how well it works over time. It is for adults with chronic back or limb pain who have not tried spinal cord stimulation before.
Phoenix, ArizonaAges 18 years+ - NCT05372822Recruiting
Testing a back pain therapy switch during spinal stimulation trial
This study tests whether changing the way spinal cord stimulation is used can better reduce long-lasting nerve pain down your leg. You must first complete a short spinal stimulation test period, and you should expect tingling during that testing time.
TrondheimAges 18 years+ - NCT06426160RecruitingPhase 2
Tocilizumab for painful chronic pancreatitis
This study tests if a drug called tocilizumab can reduce pain from chronic pancreatitis. It works by calming inflammation. You may qualify if you have had recent flare-ups and don't have other serious health issues.
Aalborg, North DenmarkAges 18 years+ - NCT07197879Recruiting
Does dynamic sitting prevent pain in office workers?
This study tests if a special swivel mechanism for office chairs can reduce or prevent back pain in people who sit a lot at work. It is for office workers who already develop pain during prolonged sitting.
Linz, Upper AustriaAges 18–65 - NCT07264270RecruitingPhase 1
A new injection for long-term sciatica pain
This trial tests a new medicine called C-1101, given as a shot into the spine, to see if it safely reduces pain from chronic sciatica. It is for people who have not gotten enough relief from standard treatments.
Broadmeadow, New South WalesAges 18–65 - NCT06350981Enrolling by invitationPhase 2/Phase 3
Pain control after lower back fusion surgery
This study is comparing different ways to manage pain after a specific type of lower back fusion surgery called TLIF. The goal is to find the best pain control plan to make recovery more comfortable.
Tampa, FloridaAges 18 years+ - NCT05452876RecruitingPhase 2
Back care program for adults with certain spine problems
This study tests a back-care pathway (a structured plan for care) for adults with specific spine-related conditions. It aims to see whether this approach improves care for people in Alberta who may benefit from organized back treatment and guidance.
Edmonton, AlbertaAges 18 years+ - NCT04816994RecruitingPhase 3
Cannabis extract for nerve back pain and painkiller needs
This trial studies whether a cannabis extract can reduce acute nerve-related pain in the back and lessen how much pain medication you need. It may help people with a short-term episode of “shooting” nerve pain from the spine.
JerusalemAges 18–70 - NCT07507604Recruiting
Spinal Adjustment and Pain Relief in Chronic Low Back Pain
This study tests whether a brief hands-on spinal adjustment can affect pain and inflammation markers in people with long-term low back pain. It aims to see if psychological factors like expectations influence how well the treatment works.
Biała Podlaska, Lublin VoivodeshipAges 18–65 - NCT06092749Recruiting
A new treatment for chronic leg and back pain
This trial tests a procedure for people with long-standing leg and back pain that hasn't improved with standard treatments like physical therapy or pain medicine.
CairoAges 21 years+ - NCT07141108Recruiting
Using a digital tool to track chronic pain and improve quality of life
This trial tests a digital tool that helps you track your pain and activity level. The goal is to see if using the tool can improve your quality of life. You would use a smartphone or tablet app and share updates with your primary care team.
Malmö, Skåne CountyAges 18 years+ - NCT05461092RecruitingEarly Phase 1
Nerve blocks to improve pain control after spinal fusion
This early-stage study tests whether a regional nerve block can improve pain control and recovery for older adults having elective lumbar spinal fusion. If you qualify, you may receive a special pain-control injection during surgery to reduce opioid needs and improve recovery comfort.
Iowa City, IowaAges 65 years+ - NCT07414017Recruiting
Virtual reality exercise for older adults with low back pain
This study tests if using virtual reality during exercise helps older adults with long-term low back pain. You'll do exercises while focusing your attention in different ways, and researchers will see which method works best for reducing pain and improving movement.
Center, Kirşehi̇rAges 65–80 - NCT06860867Recruiting
Nucleus replacement for single-level discogenic low back pain
This trial tests a new device called PerQdisc for people with chronic low back pain from a single damaged disc in the lower spine. The goal is to see if the device can safely replace the inner gel of the disc without major surgery.
Glendale, ArizonaAges 22–70 - NCT04381208Recruiting
Using health and movement data to diagnose sacroiliac pain
This study looks at medical records and physical/neurological exam findings to help diagnose sacroiliac joint dysfunction, a common source of chronic low back or buttock pain. It may help your care team better sort out what’s causing your pain and choose the right next steps.
Valencia, ValenciaAges 18 years+ - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT05066308RecruitingPhase 2
Cannabidiol to reduce inflammation in chronic low back pain
This Phase 2 study tests cannabidiol (CBD) to calm inflammation in the brain that may be linked to chronic low back pain. If you qualify, you’ll take study CBD and undergo brain imaging to see whether inflammation changes.
Boston, MassachusettsAges 18–75 - NCT05142267Recruiting
Study stress and opioid-risk factors in chronic low back pain
This study looks at how stress and the body’s natural opioid/cannabinoid systems may relate to risk of opioid misuse. It tests people with long-lasting low back pain to see what biological or psychological factors might increase or lower that risk.
Nashville, TennesseeAges 18 years+ - NCT05556902Recruiting
Testing how epidural spinal cord stimulation may help chronic pain
This study looks at how a device that sends mild signals to the area around your spinal cord may work for long-lasting (chronic) pain. You may be asked to visit a research lab, have blood taken, and follow the study plan so researchers can understand the treatment’s effects.
Birmingham, AlabamaAges 18–89 - NCT05585229RecruitingPhase 2
Psilocybin therapy to help you taper opioid pain medicine
This Phase 2 study tests a structured, therapist-led treatment using standardized natural psilocybin to help people reduce or stop long-term opioid use for chronic (non-cancer) pain. It’s mainly for those who have tried tapering before but couldn’t, and who are motivated to try again.
Kelowna, British ColumbiaAges 19–75 - NCT05641948Recruiting
Tested nerve ablation plus brain scans for ongoing back pain
This trial studies a procedure called radiofrequency denervation to reduce long-lasting, mostly “pain-from-joints/structures” low back pain, and it uses brain imaging to understand what changes during treatment. It may help people who already showed they respond well to a similar diagnostic nerve block.
Aberdeen, ScotlandAges 18 years+ - NCT05661903RecruitingPhase 2
Spinal cord stimulator study for nerve pain and brain effects
This Phase 2 study looks at how spinal cord (or nerve-root) stimulation affects pain signals in the brain and body. You may qualify if you already have a stimulator set to a comfort mode that avoids “tingling” sensations.
Boston, MassachusettsAges 18–80
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Common questions
- Are there clinical trials for chronic back pain?
- Yes. Clin2 currently lists 331 recruiting chronic back pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic back pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic back pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.