Clinical trials
Chronic Disease clinical trials
Below are recruiting chronic disease clinical trials, each written for real people, not researchers. We’re tracking 1,256 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07620925Recruiting
Aortic Valve Calcium Score Study Using Heart Ultrasound
This study develops and tests a new way to diagnose severe aortic stenosis (narrowing of the aortic valve) by measuring calcium buildup on the valve using heart ultrasound. If you're already getting both an ultrasound and a CT scan of your heart, this study compares how well the ultrasound method can identify severe stenosis.
BolognaAges 18 years+ - NCT05417685Enrolling by invitation
Digital physical therapy for musculoskeletal pain
This trial studies a smartphone/tablet-based care program to help people with neck, back, shoulder, elbow, wrist/hand, hip, knee, or ankle pain. It may help reduce pain and improve function using guided exercises, as long as it is safe for you to do light-to-moderate activity.
Draper, UtahAges 18 years+ - NCT06712810RecruitingPhase 1
Q702 for blood cancers and histiocytic disorders
This study tests an experimental pill called Q702 for people with certain blood cancers and related disorders (like histiocytoses, myelofibrosis, and lymphomas) that have not responded to standard treatments. It aims to see if Q702 is safe and effective.
Scottsdale, ArizonaAges 18 years+ - NCT06053242RecruitingPhase 1/Phase 2
Stem cell injection for long-term low back pain
This trial tests a new stem cell injection (CELZ-201-DDT) into a muscle to treat chronic lower back pain that hasn't improved with standard treatments. It aims to see if the injection is safe and effective for people aged 18 to 80 with moderate to severe back pain.
Aventura, FloridaAges 18–80 - NCT07068789Recruiting
Leg Artery Bypass: One vs. Multiple Vessels for Severe Limb Threat
This trial compares opening up one versus multiple blood vessels below the knee to improve blood flow in people with severe leg pain or wounds. It aims to find the best approach to save the limb and improve quality of life.
Sohag, Sohag GovernorateAges 40 years+ - NCT06041581Enrolling by invitation
Insomnia treatment study for heart health
This study tests whether treating insomnia can help lower your risk for heart disease. If you have trouble sleeping and certain heart risk factors, you may be able to join.
Indianapolis, IndianaAges 40 years+ - NCT06480786Recruiting
Spinal cord stimulator for diabetic nerve and artery pain
This study tests if a spinal cord stimulator (a device that sends mild electrical pulses to the spine) can relieve severe leg pain caused by diabetic nerve damage and poor blood flow. It may help people who have not found enough relief from other treatments.
Omaha, NebraskaAges 19–89 - NCT02795052Recruiting
Stem cell treatment trial for nerve injury
This study tests whether bone-marrow stem cells can improve nerve function in people with nerve damage that usually doesn’t recover with current care. It also checks whether the treatment is safe and whether people can be followed over time with repeated nerve exams.
Westport, ConnecticutAges 18 years+ - NCT05313165Recruiting
Stent procedure for poor blood flow in the leg ulcers and gangrene
This trial tests a new minimally invasive procedure (placing a small stent) to improve blood flow to a severely threatened foot or lower leg. It may help people whose ulcers or gangrene are not treatable with standard bypass or other surgeries.
La Jolla, CaliforniaAges 18–95 - NCT07072026Recruiting
Opening blocked arteries in the brain long after stroke
This trial looks back at patients who had a procedure to reopen a major artery in the brain that had been blocked for a long time. It will help doctors learn if this treatment is safe and effective for people with chronic blockages in certain key arteries.
EssenAges 18 years+ - NCT04028687Recruiting
Study of a hip stem used in select adult hip replacements
This trial follows people who have had a hip replacement using a specific “Taperloc Complete” stem. It is meant to monitor outcomes after surgery and see how well the stem performs over time for certain non-infectious hip problems.
Henderson, NevadaAges 18 years+ - NCT04124029Recruiting
Study how mild brain injuries may relate to dementia
This study looks at how past mild traumatic brain injury may contribute to brain changes seen in chronic traumatic encephalopathy (CTE) and Alzheimer’s disease (AD). It may help researchers understand risk and brain markers by comparing people with mild or moderate TBI, people with mild memory problems, and healthy controls.
Boston, MassachusettsAges 30–90 - NCT06016257Recruiting
Virtual home exercise program for shoulder rehab
This study tests a virtual home exercise program (VirtuaCare) for people with shoulder problems who need physical therapy. It aims to see if doing exercises at home with virtual guidance works as well as standard care.
Los Angeles, CaliforniaAges 18 years+ - NCT06224140Recruiting
Dialysis without heparin: a safety study
This study tests whether dialysis can be done safely without using heparin (a blood thinner) in people with end-stage kidney disease. If successful, it could reduce the need for blood-thinning medications and their associated risks.
Marseille, Bouches du RhôneAges 18 years+ - NCT06537700Recruiting
Testing Botox for Chronic Migraine: Does Timing Matter?
This study tests how well Botox works for chronic migraine patients, depending on how long they've had the condition. If you have chronic migraines, haven't had Botox recently, and meet a few other conditions, you may be able to join.
AnconaAges 18–70 - NCT06747052Recruiting
How gender affects physical activity for preventing joint pain
This study looks at how being male or female affects physical activity habits and how that might help prevent long-term muscle and joint problems. It is open to adults in Lombardy, Italy, who can speak Italian.
Milan, ItalyAges 18–64 - NCT06793787Recruiting
AI and advanced imaging to guide treatment of borderline heart blockages
This study uses advanced CT scans and a special camera (OCT) to look at borderline blockages in heart arteries more closely. It aims to see if artificial intelligence can help decide which blockages need a stent and which can be treated with medicine alone.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06708000Enrolling by invitationPhase 3
Personalized testing for new chest pain
This trial compares a personalized evaluation approach to standard care for people with new chest pain who might have heart disease. It aims to see if tailoring tests can improve diagnosis and outcomes.
HerningAges 30–75 - NCT05199870Enrolling by invitation
Long-term follow-up for specific hip implant parts
This study follows people who had a particular bipolar hip implant (RingLoc cup and/or Endo II head) placed during a hemi-hip replacement surgery at least 8 years ago. It checks how well the implants keep working over time and why.
Falls Church, VirginiaAges 18 years+ - NCT05870969Recruiting
Digital monitoring to catch liver cancer risk early
This study tests a digital (computer/phone-based) system to help track people with higher risk of liver cancer so cancers can be found earlier. It may help by guiding regular check-ins and making early diagnosis more efficient.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06468774Recruiting
Test for gut ischemia in chronic belly artery disease
This study tests a blood marker for chronic mesenteric ischemia (poor blood flow to the gut). If it works, it could help doctors diagnose the condition faster and more easily.
Oslo, OsloAges 18 years+ - NCT04758975RecruitingPhase 2
Venetoclax plus rituximab plus ibrutinib for early CLL
This Phase 2 trial tests a combination of three medicines to treat chronic lymphocytic leukemia (CLL) that has not been treated before and where the goal is to achieve very low remaining disease. It may help some people stay in remission longer, but eligibility depends on your age, organ function, and prior treatments.
Milan, MIAges 18–65 - NCT06075602Recruiting
Complex and calcified coronary artery disease: a registry study
This study watches how people with complex or calcified heart artery disease are treated (with stents or bypass surgery) and how they do over time. It aims to learn which treatments work best for tough blockages.
Lucerne, Canton of LucerneAges 18 years+ - NCT05956379Enrolling by invitation
Exercise and monitoring study for chronic hepatitis B with fatty liver
This study follows adults with chronic hepatitis B who also have fatty liver and tests an exercise approach to see how it affects liver health. You may be followed over time and helped with an exercise plan if you qualify.
Taipei, Zhongzheng Dist.Ages 18–70
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Common questions
- Are there clinical trials for chronic disease?
- Yes. Clin2 currently lists 1,256 recruiting chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.