Chronic Ischemic Stroke clinical trials

Stroke study for patients on blood thinners

This study looks at people who had a stroke while taking blood thinners (anticoagulants) for an irregular heartbeat. It aims to learn more about these strokes and how to better prevent them in the future.

Vagus nerve stimulation for reducing inflammation after stroke

This trial tests whether a non-invasive device that stimulates the vagus nerve can reduce inflammation and brain injury after a stroke caused by a large blood clot.

Testing new blood markers for brain blood flow problems

This study is testing whether certain substances in your blood can help doctors better detect and understand problems with blood flow in the brain. Researchers hope these new 'biomarkers' could lead to faster and more accurate diagnosis of conditions like stroke and mini-stroke.

New stroke medicine SP-8203 with clot-busting therapy

This trial tests a new medicine called SP-8203 added to standard clot-busting treatment for people having a moderate to severe stroke. The goal is to see if it helps improve recovery and is safe.

Study of a drug for stroke patients after blood clot treatment

This trial tests if adding a drug called human urinary kallidinogenase (HUK) can improve recovery for people who have had a stroke and already received clot-busting medicine or a procedure to remove the clot. The goal is to see if it helps reduce disability after a stroke.

Clot-busting drug through artery for medium-vessel stroke

This trial tests a clot-busting drug given directly into the arteries of the brain for people who have had a stroke due to a blockage in a medium-sized artery. It aims to see if this treatment can help improve recovery when started up to 72 hours after symptoms begin.

New imaging & catheter system for blocked heart arteries

This trial tests a new imaging and catheter system to treat chronic total blockages in heart arteries. If you still have chest pain or other symptoms despite medical therapy, this study may help open the blockage and improve blood flow.

Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation Monitoring

Aleeto for acute ischemic stroke: a randomized trial

This trial tests a drug called Aleeto in people who have had an acute ischemic stroke (a stroke caused by a blocked blood vessel) within the last 72 hours. It aims to see if Aleeto can improve recovery and reduce disability.

QD202 Study for Recent Stroke Treated With Clot-Busting Medicine

This study tests whether a new drug called QD202 can help protect the brain and improve recovery when given alongside standard clot-busting therapy (thrombolysis) for acute ischemic stroke. You would be in the trial if you had a stroke in the last 24 hours and are receiving or planning to receive thrombolytic treatment.

Ischemic conditioning after stroke clot removal

This trial tests a method called direct ischemic conditioning, which is a gentle way to prepare your brain to better handle the return of blood flow after a stroke. It is for people who have had a large artery blockage in the front part of the brain and have already had a successful procedure to reopen the artery.

Wrist sensor app to help use the weaker arm at home

This Phase 2 study tests a new wrist sensor system that tracks arm movement and gives feedback using a phone or tablet. It aims to improve daily use of the weaker (hemiparetic) arm in people with a prior stroke.

Study uses MRI and blood clues after ischemic stroke

This study looks for biological and imaging markers that may predict heart/vascular outcomes after an ischemic stroke. You may join if you are eligible for standard stroke treatment and can complete planned follow-up and MRI scans.

Blood-sample study of stroke patterns using multiple tests

This study looks at blood and lab “molecular” patterns in people who have had an ischemic stroke (a blocked blood vessel). It aims to understand differences between people labeled as having “phlegm-heat syndrome” versus not, which may help future stroke care. You may be eligible if your stroke was recent and confirmed by MRI.

Endovascular treatment for worsening mild stroke with basilar artery blockage

This trial tests a procedure to open a blocked artery in the back of the brain (basilar artery) for people who had a mild stroke that later got worse. If you are eligible, you may receive this treatment up to 24 hours after your symptoms worsen.

Hand therapy for stroke: may help speech and swallowing

This study tests whether a special hand therapy using brain-computer interface and electrical stimulation can also help improve speech and swallowing problems after a stroke. You may be eligible if you're at least 3 months past your stroke, have some arm weakness, and have aphasia or dysphagia.

Edaravone Dexborneol tablet for stroke recovery

This trial tests a new sublingual tablet (Edaravone Dexborneol) to help people recover after a small stroke caused by disease of the small blood vessels in the brain. It aims to see if the drug can improve thinking and daily function.

Wearable device and coaching to improve arm use after stroke

This study tests whether a wearable device that tracks arm movement, plus coaching to use your weaker arm more, can help you recover better after a stroke. It's for people who are at least 6 months past their stroke and have some arm weakness but can still use their hand.

Brain stimulation plus rehab to improve thinking after stroke

This study tests whether a noninvasive brain stimulation treatment, combined with rehabilitation, can improve thinking and other “neurocognition” problems after a recent stroke. It may help people whose thinking has been affected by stroke within the past month.

Brain artery calcium and clot removal outcomes

This study looks at whether calcium buildup in brain arteries affects how well clot removal (mechanical thrombectomy) works for stroke patients. You may be able to join if you have a large artery blockage, a CT scan was done, and you are having the clot removal procedure.

Brain stimulation to improve arm movement after stroke

This study tests a new type of non-invasive brain stimulation to help people with arm weakness after a stroke improve their movement and daily function.

Movement and brain function after chronic stroke

This study looks at how stroke affects your movement and nervous system over time. You will do simple movement tests and answer quality-of-life surveys to help researchers understand how to improve recovery.

Balance and walking exercises for chronic stroke recovery

This study compares two types of walking and balance exercises for people who had a stroke 6 to 12 months ago. It aims to see which type of practice helps improve balance and walking best.

Robotic therapy timing to improve arm movement after stroke

This trial studies whether giving robotic therapy to the shoulder and arm in a “priority” way (instead of focusing on the hand first) helps improve arm movement in people with chronic stroke. It may help by improving how your arm muscles and joints are trained to work together.