Clinical trials
Chronic Knee Osteoarthritis clinical trials
Below are recruiting chronic knee osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 120 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06773676Recruiting
Home laser device study for knee osteoarthritis relief
This study tests whether using a laser device at home can help reduce knee pain and improve function in people with knee osteoarthritis. You would use the device yourself over several weeks to see if it eases your symptoms.
Ashkelon, Southern DistrictAges 50–90 - NCT07439575Recruiting
Wound closure methods in hip and knee replacement
This study compares different ways of closing the wound after hip or knee replacement surgery. It looks at which methods heal best with fewer problems.
Istanbul, IstanbulAges 30 years+ - NCT07226258RecruitingPhase 3
Testing SL1002 for knee pain caused by osteoarthritis
This trial tests a study drug called SL1002 to see if it reduces knee pain from osteoarthritis. It may be an option for people with chronic knee pain who haven't found enough relief from current treatments.
Roseville, CaliforniaAges 40 years+ - NCT07219771RecruitingPhase 3
Testing MOTYS injection for knee osteoarthritis pain
This trial tests an injection called PTP-001 (MOTYS) for people with mild to moderate knee osteoarthritis. It aims to see if the injection can reduce knee pain and improve function.
Birmingham, AlabamaAges 40–80 - NCT05543941Recruiting
Test advanced irrigation during knee, hip, or shoulder replacement
This trial studies a cleaning solution used during surgery to lower the risk of complications and improve outcomes after joint replacement. It may be an option if you’re having a planned knee, hip, or humerus (shoulder) replacement and meet the specific health and allergy requirements.
Vancouver, British ColumbiaAges 18 years+ - NCT05302934Recruiting
Testing a knee-surgery app and sensor after knee replacement
This trial checks whether a data platform that uses a wearable sensor and a phone app works well for people getting a total knee replacement. It may help make follow-up care more organized and easier by capturing recovery information.
Konstanz, Baden-WurttembergAges 18 years+ - NCT07425457Recruiting
Cold nerve treatment before knee replacement surgery
This trial tests a cold therapy on nerves before knee replacement to reduce pain. It may help you recover with less discomfort after surgery.
AthensAges 18 years+ - NCT06123715RecruitingPhase 2
Vitamin C to reduce pain after knee replacement
This study tests whether taking vitamin C before and after knee replacement surgery can reduce long-term pain. You may be eligible if you are having knee replacement for osteoarthritis and are generally healthy.
Toronto, OntarioAges 18 years+ - NCT06807541Recruiting
Exercise for balance in knee osteoarthritis
This pilot study tests whether a group exercise program can improve balance for people with knee osteoarthritis. You would join supervised exercise classes to see if they help with stability and daily movement.
Chilliwack, British ColumbiaAges Any age - NCT06800209RecruitingPhase 2
Pain Reprocessing Therapy for ongoing knee pain after replacement
This study tests if Pain Reprocessing Therapy can help reduce knee pain that continues 3 months after a knee replacement. It uses a telehealth approach so you can participate from home.
Aurora, ColoradoAges 18 years+ - NCT07746284Enrolling by invitation
Understanding knee osteoarthritis through computer modeling
This study looks at how knee osteoarthritis pain works and aims to build a computer model to better understand it. By joining, you may help doctors improve future treatments for chronic knee pain.
Herndon, VirginiaAges 18–99 - NCT07339137Recruiting
PRP injections for chronic knee osteoarthritis
This trial tests if platelet-rich plasma (PRP) injections into and around the knee joint can reduce pain and improve function for people with moderate knee osteoarthritis who haven't gotten relief from other treatments.
Ankara, ÇankayaAges 40–65 - NCT07351981Enrolling by invitation
Cooled radiofrequency for knee osteoarthritis pain
This study tests a new approach called cooled radiofrequency (TcPRF) to calm knee pain from osteoarthritis. It may be an option if standard treatments haven't worked and you haven't had certain other treatments recently.
AthensAges 45 years+ - NCT07338266RecruitingPhase 1
Study of AVD275 injection for knee osteoarthritis
This trial tests a new injection called AVD275 for people with knee osteoarthritis. It aims to see if the injection is safe and how it works in the body.
Wahroonga, New South WalesAges 20–75 - NCT07838012Recruiting
Early home cycling after knee replacement surgery
This study tests whether starting gentle cycling at home soon after knee replacement surgery is safe and helpful. It aims to see if patients can use a stationary bike to speed up recovery.
Silkeborg, Central JutlandAges 18 years+ - NCT06617871Recruiting
Comparing two ways to align a new knee replacement
This study compares two different techniques (mechanical alignment vs. kinematic alignment) used during knee replacement surgery with a special knee system. It aims to see which technique leads to better results for patients.
Chicago, IllinoisAges 21–79 - NCT06603662RecruitingPhase 4
Steroids for sudden osteoarthritis pain in the emergency room
This trial tests if a short course of oral steroids (glucocorticoids) can relieve sudden osteoarthritis pain in the knee, hip, or shoulder for people who come to the emergency department and are well enough to go home.
York, PennsylvaniaAges 18 years+ - NCT07396233Recruiting
Knee Osteoarthritis Therapy: Diagonal Movement Patterns
This trial tests a type of physical therapy called proprioceptive neuromuscular facilitation for people with knee osteoarthritis. It may help reduce pain and improve how well your knee works.
Karachi, SindhAges 40–60 - NCT07666347Recruiting
Botox and Hyaluronic Acid Injections for Knee Osteoarthritis
This study tests if injecting Botox and hyaluronic acid into the knee joint can reduce pain and improve function in people with advanced knee osteoarthritis. It compares this combination to a standard treatment.
Tanta, El-GharbiaAges 50 years+ - NCT07442812Recruiting
Dexamethasone: pill vs. IV for knee replacement recovery
This trial compares two ways of giving dexamethasone (a strong anti-inflammatory) for people having knee replacement surgery. One group gets a pill and the other gets an IV. The goal is to see which method works better for pain, swelling, and recovery.
Istanbul, IstanbulAges 50–80 - NCT07789340Recruiting
Radiofrequency treatment for knee osteoarthritis pain
This study compares two types of radiofrequency treatment to reduce knee pain from osteoarthritis. It may help people whose knee pain has not improved with other treatments like physical therapy or injections.
Tanta, El-GharbiaAges 50 years+ - NCT06187038Recruiting
Pain education study for knee osteoarthritis
This trial tests if learning about chronic pain can help people with knee osteoarthritis feel better. You'll join a program that teaches you about pain and how to manage it.
São PauloAges 40–80 - NCT06863636RecruitingPhase 3
Combination painkiller vs celecoxib for osteoarthritis flare-ups
This study tests whether a combination of two pain relievers (celecoxib and acetaminophen) works better than celecoxib alone for sudden, severe osteoarthritis pain in the knee or hip.
Mexico CityAges 40 years+ - NCT07855367Recruiting
Knee pain relief study for osteoarthritis patients
This study compares two procedures that use extreme cold or heat to target the nerves around the knee, with the goal of reducing pain from knee osteoarthritis. It is specifically for people with advanced knee osteoarthritis who also have bladder cancer.
CairoAges 40 years+
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Common questions
- Are there clinical trials for chronic knee osteoarthritis?
- Yes. Clin2 currently lists 120 recruiting chronic knee osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic knee osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic knee osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.