Clinical trials
Chronic Knee Osteoarthritis clinical trials
Below are recruiting chronic knee osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 124 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07449442Recruiting
Pain relief study after knee replacement surgery
This trial tests a special injection around the knee to improve pain control after knee replacement surgery. It may help reduce the need for strong pain medicines.
PoznanAges 65–100 - NCT07339111RecruitingPhase 3
CARTISTEM vs surgery for knee cartilage damage and osteoarthritis
This trial tests if a cell-based treatment called CARTISTEM can repair knee cartilage better than surgery alone. It involves people with knee osteoarthritis and a cartilage defect, with moderate pain and limited function.
Birmingham, AlabamaAges 18–75 - NCT06423716RecruitingPhase 4
Duloxetine to reduce opioid use after knee replacement
This study tests whether taking the pain medication duloxetine before and after knee replacement surgery can reduce the need for opioid painkillers. It may help patients manage pain with fewer side effects from strong narcotics.
Toronto, OntarioAges 50 years+ - NCT03877653Recruiting
Freedom-1 treatment for long-term knee pain in adults
This study tests a procedure called Freedom-1 to reduce long-term, limiting knee pain from knee arthritis. It may help if other non-surgical options didn’t work and you meet specific knee and health requirements.
Placentia, CaliforniaAges 18 years+ - NCT06188806Recruiting
Nerve block location study for knee replacement pain
This study compares two types of nerve blocks (proximal vs. distal adductor canal block) for pain relief after knee replacement surgery. The goal is to see which approach provides better pain control and recovery.
Istanbul, UmraniyeAges 18–85 - NCT07775248RecruitingPhase 4
Long-lasting pain relief after knee replacement
This trial tests a new type of pain medicine that is given during knee replacement surgery and slowly releases pain relief over several days. It may help reduce the need for opioid painkillers after surgery.
Grosse Pointe Farms, MichiganAges 18 years+ - NCT06488144RecruitingPhase 3
Knee arthritis rehab: helping veterans keep improving
This study tests a program that helps veterans with knee osteoarthritis keep up the gains they make in physical therapy. It uses a Fitbit and a smartphone app to support you and track your activity after your PT sessions end.
Birmingham, AlabamaAges 40–90 - NCT06686680Recruiting
Shockwave therapy for knee arthritis after ACL repair
This study tests whether shockwave therapy can help knee pain and function in people who developed knee osteoarthritis after an ACL reconstruction. If you had ACL surgery at least a year ago and still have knee pain, this treatment might offer a new option without surgery.
Cambridge, MassachusettsAges 18–55 - NCT07397806Recruiting
Home-based leg trainer for knee osteoarthritis
This study tests a home exercise device designed to improve leg control and reduce pain in people with knee osteoarthritis. You may be eligible if you have knee pain and are between 40 and 85 years old.
Vail, ColoradoAges 40–85 - NCT06514365Recruiting
Comparing nerve blocks for pain after knee replacement
This trial compares two different ways of numbing the leg to provide better pain relief after total knee replacement surgery. It tests whether adding a popliteal sciatic nerve block (behind the knee) to a saphenous block (inner thigh) works better than adding an IPACK block (back of the knee).
Badalona, BarcelonaAges 18 years+ - NCT06906939RecruitingEarly Phase 1
Brain stimulation and tai chi for knee arthritis and depression
This pilot study tests if combining brain stimulation (rTMS) with Tai Chi can help knee arthritis pain and improve depression. It compares these two treatments to see which works better for people with both pain and low mood.
Los Angeles, CaliforniaAges 50–95 - NCT07367126Recruiting
Nerve pain in knee osteoarthritis: Pain and function study
This study looks at nerve-related pain in people with knee osteoarthritis and how it affects their pain level and daily function. It may help understand if nerve pain is a key factor in your knee OA symptoms.
IstanbulAges 40–70 - NCT07347028Recruiting
Trigger point injections for knee osteoarthritis pain
This trial tests whether injecting medication into muscle knots (trigger points) can reduce knee pain in people with knee osteoarthritis. It may be an option if other treatments haven't helped enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT07119645Recruiting
Collagen supplement for knee discomfort relief
This trial tests whether a daily collagen supplement (NT-II™) can reduce knee discomfort during activities like walking or climbing stairs. You may qualify if you have mild to moderate knee pain during exercise, no arthritis, and are generally healthy.
San Francisco, CaliforniaAges 20–65 - NCT07361198Recruiting
Knee artery embolization for arthritis pain
This trial tests a minimally invasive procedure to block small blood vessels in the knee, which may reduce pain from osteoarthritis. It's for people with ongoing knee pain even after standard treatments like medication or physical therapy.
Ústí nad LabemAges 40–80 - NCT07496203Recruiting
BETY program after knee injections for osteoarthritis
This trial tests if a special exercise and education program called BETY helps people with knee osteoarthritis feel better after getting a knee injection. You may qualify if you had a knee injection in the last month and have moderate knee arthritis.
Ankara, SamanpazarıAges 18 years+ - NCT06637709Recruiting
Pain after osteoarthritis treatment: a 24-month study
This study looks at why some people still have pain after knee surgery or other treatments for osteoarthritis. It tests a marker in the blood to see if it relates to ongoing pain. You would be followed for 24 months.
Roma, RomaAges 18–99 - NCT05806021RecruitingPhase 4
Tested different cortisone doses for knee osteoarthritis pain
This trial compares different doses of injected cortisone (triamcinolone) directly into the knee to see which dose helps knee osteoarthritis pain most. You may be enrolled in a group receiving a 5 mg, 10 mg, or 40 mg dose if you meet the study’s knee and health requirements.
Montreal, QuebecAges 50 years+ - NCT05211986RecruitingPhase 1/Phase 2
Test injection safety for knee osteoarthritis muscle weakness
This Phase 1/2 trial studies whether an injection called IMM01-STEM is safe and well-tolerated for people with knee osteoarthritis who also have muscle weakness. It also looks at whether the treatment could help in this group, while carefully monitoring side effects.
Irvine, CaliforniaAges 50–75 - NCT06902285RecruitingPhase 4
Magnesium supplement for better sleep after joint replacement
This study tests whether taking magnesium L-threonate can improve sleep quality after total knee or hip replacement surgery. It may help you sleep better during recovery.
Miami, FloridaAges 18 years+ - NCT07281651Recruiting
Understanding pain sensitivity in knee pain and fibromyalgia
This study looks at how the brain and nerves process pain in people with knee pain or fibromyalgia. It compares them to pain-free people to understand differences in muscle signals.
Derby, DerbyshireAges 40 years+ - NCT07386600Recruiting
Comparing two drugs for knee replacement pain relief
This trial tests two different drugs (dexamethasone and dexmedetomidine) added to a standard nerve block for knee replacement. It aims to see which one provides better pain control after surgery.
PoznanAges 65–100 - NCT07727551Recruiting
Nerve block before knee replacement for better recovery
This trial tests if a nerve block given a few weeks before knee replacement surgery can improve pain and function after the operation. It is designed for people who have certain risk factors that might make recovery harder.
BrusselsAges 18–60 - NCT07764354Recruiting
Patient education for sticking with home exercises
This study tests whether extra education helps people with chronic musculoskeletal conditions—like long-term back pain, knee arthritis, or partial rotator cuff tears—stick with their home exercise routines to feel better. If you have one of these conditions and are willing to follow a home exercise plan, this could help you manage pain.
Dammam, Eastern ProvinceAges Any age
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Common questions
- Are there clinical trials for chronic knee osteoarthritis?
- Yes. Clin2 currently lists 124 recruiting chronic knee osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic knee osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic knee osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.