Clinical trials
Chronic Opioid Use clinical trials
Below are recruiting chronic opioid use clinical trials, each written for real people, not researchers. We’re tracking 101 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06909851Recruiting
Comparing nerve blocks for pain after knee arthroscopy
This study compares two different types of nerve blocks to see which provides better pain relief after arthroscopic knee surgery. You will receive one of the blocks after your surgery, and your pain levels will be tracked.
IstanbulAges 18–72 - NCT07215546Enrolling by invitation
Stopping pain after heart surgery with a special chest closure
This trial tests a new device to close the breastbone after open-heart surgery to see if it helps reduce the need for prescription pain medicine. The device is designed to hold the bone together more securely, which may lead to less pain and faster recovery.
Naples, FloridaAges 19–80 - NCT07104825Recruiting
Nerve block for pain after weight loss surgery
This trial tests if a nerve block can help control pain after gastric bypass or sleeve gastrectomy. The goal is to reduce the need for strong pain medicines and improve recovery.
Evanston, IllinoisAges 18–90 - NCT06992427RecruitingPhase 3
Gabapentin to prevent opioid use for mouth pain during cancer treatment
This trial tests if taking gabapentin during chemoradiation for head and neck cancer can reduce the need for strong painkillers like opioids. It may help manage mouth pain caused by treatment.
Gilbert, ArizonaAges 18 years+ - NCT06877858RecruitingPhase 1
MethaLoad dose-finding study for opioid use disorder
This study tests a new way to start methadone treatment (called 'MethaLoad') for people with opioid use disorder who have used fentanyl. If you qualify, you will receive methadone to help manage withdrawal and reduce cravings, and the doctors will closely monitor your safety and response.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06639438Recruiting
Sensory outcomes in people who use opioids
This study looks at how opioids affect the senses in people having planned surgery. Researchers want to compare patients who use opioids (for pain or addiction) with those who don't, to see if there are differences in sensation.
Boston, MassachusettsAges 18 years+ - NCT06015711Recruiting
Does a pre-surgery painkiller reduce strong IV pain meds needed?
This trial tests if taking Maxigesic® (a combination of two pain relievers) before surgery can lower the amount of a strong IV pain medicine called remifentanil needed during anesthesia. It may help patients have a smoother recovery with fewer side effects.
Suwon, Gyeonggi-doAges 19–60 - NCT04724252RecruitingPhase 2/Phase 3
Gabapentin to help children use less opioid after surgery
This study tests whether gabapentin can reduce how much opioid pain medicine children need after certain major chest or heart surgeries. If it works, it may lower opioid-related side effects while still helping with postoperative pain.
Sacramento, CaliforniaAges Up to 17 years - NCT06077422Enrolling by invitationPhase 2/Phase 3
Comparing two pain blocks for heart surgery recovery
This trial compares two types of pain blocks (Exparel vs. Marcaine) given during heart surgery to see which one provides better pain relief. If you are scheduled for a heart surgery through a small or full chest incision, you may be able to join.
New Brunswick, New JerseyAges 18 years+ - NCT06051890RecruitingPhase 4
Assessing switching to long-acting buprenorphine injection in jail
This study tests whether switching from daily buprenorphine/naloxone (Suboxone) to a long-acting injectable buprenorphine (XRB) is safe and effective for men who are unsentenced and in jail for at least 4 days. It aims to see if the injection can help continue treatment without needing daily medication.
Boston, MassachusettsAges Any age - NCT05380531Recruiting
Personalized pain plan for planned C-section using opioid options
This trial tests a personalized approach to pain control during and after a scheduled C-section. It may help by matching pain medicine choices to each person’s needs, including the use of in-hospital opioids for relief.
Indianapolis, IndianaAges 18 years+ - NCT06574009RecruitingPhase 4
Better options for chronic cancer pain in veterans
This study tests if switching from long-term opioid painkillers to buprenorphine (a different type of pain medication) can provide better pain relief for veterans who have had cancer but are currently cancer-free. It aims to find a safer and more effective way to manage chronic pain.
Indianapolis, IndianaAges 18–99 - NCT07228377Recruiting
Virtual reality for cancer pain and opioid use
This study tests if using virtual reality can help manage chronic cancer pain and reduce the amount of opioid pain medicine needed. You would use a VR headset at home and report how you feel.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05555485Recruiting
Check if ear stimulation can help chronic pain and reduce opioids
This study tests whether a device that stimulates the ear (through the skin) can reduce chronic pain and help people lower their opioid pain medicine. It may help you manage pain with less opioid use if you meet their safety and medication criteria.
Galveston, TexasAges 18–65 - NCT07457489Recruiting
Brain stimulation for opioid recovery
This study tests a non-invasive brain stimulation technique called TMS to see if it can reduce opioid cravings and help people who are already taking buprenorphine stay in recovery. TMS uses magnetic pulses to stimulate parts of the brain involved in addiction.
Brentwood, TennesseeAges 18–65 - NCT06706375Recruiting
Comparing two types of penile nerve blocks for child circumcision
This study tests two ways of numbing the penis before circumcision in children. The goal is to see which method works better and causes less discomfort.
Lausanne, Canton of VaudAges Up to 17 years - NCT05985811Recruiting
Ketamine for chronic pain and mood in adults
This trial tests if ketamine injections can improve both pain and mood in adults with chronic pain who also have a mood disorder and trouble sleeping. It may help if you already get regular ketamine treatments.
Surrey, British ColumbiaAges 20–99 - NCT07336849Recruiting
Embolization for chronic shoulder pain not helped by other treatments
This trial tests a minimally invasive procedure called transcatheter arterial embolization using tiny particles (Nexsphere-F) to reduce chronic shoulder pain that has not improved with physical therapy, medications, or injections. It aims to see if this treatment can safely improve pain and shoulder movement.
SeoulAges 19–85 - NCT06027099RecruitingPhase 3
Testing tizanidine to help reduce opioids after surgery
This study tests whether adding a low-dose muscle relaxant (tizanidine) to your pain plan after surgery can help you safely lower your opioid use. It's for people who have been on long-term opioids and are having surgery at specific hospitals.
Stanford, CaliforniaAges 18–75 - NCT06861920RecruitingPhase 4
NSAID use for painful periods to prevent chronic pelvic pain
This study tests whether using NSAIDs (like naproxen) for painful periods can help prevent chronic pelvic pain later on. It's for people with regular, painful periods who are otherwise healthy.
Evanston, IllinoisAges 18–35 - NCT07403331Recruiting
Nerve pain in legs: spinal cord stimulation plus team care
This trial tests a treatment bundle that combines a spinal cord stimulator (a device that sends mild electrical pulses to your spine to block pain signals) with a team of specialists (like a psychologist and physical therapist) to reduce chronic nerve pain in the legs and improve your ability to move and function.
OsloAges 18–60 - NCT05769348Recruiting
PET brain study to test opioid signaling in migraine
This study uses brain scans (PET) to look at how the body’s “opioid” pain system works in people with migraine. It may help researchers understand migraine biology and test approaches that could improve migraine treatment.
Ann Arbor, MichiganAges 18–65 - NCT06555107Recruiting
Pain before emergency surgery and long-term pain after
This study looks at whether pain you feel before emergency surgery affects long-term pain after the surgery. It may help doctors find ways to prevent chronic pain in patients who have emergency orthopedic (bone/joint) or abdominal (belly) surgery.
AmiensAges 18 years+ - NCT06856733Recruiting
Better opioid management for long-term non-cancer pain
This study tests a new way to help people who have been taking opioids for chronic pain (not caused by cancer) for at least 90 days. The goal is to improve treatment and reduce risks, such as developing tolerance or side effects, while still managing pain effectively.
Gävle, Gävleborg CountyAges 18–70
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Common questions
- Are there clinical trials for chronic opioid use?
- Yes. Clin2 currently lists 101 recruiting chronic opioid use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic opioid use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic opioid use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.