Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 793 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07652944Recruiting
Magnetic field therapy for chronic lower back pain
This trial tests whether magnetic fields applied to your back can relieve chronic lower back pain that has lasted at least 12 weeks. It's for people aged 18 to 64 who are willing to attend all study visits.
Edwards Air Force Base, CaliforniaAges 18–64 - NCT07214844Recruiting
Freezing vs. heating nerves for chronic low back pain
This study compares two procedures to treat long-term low back pain from the small joints in your spine. One uses extreme cold, the other uses heat to stop pain signals. It may help if you have had at least three months of back pain and other treatments haven't worked.
The Bronx, New YorkAges 18 years+ - NCT07198412Recruiting
Study on sedation's effect on back pain after spinal anesthesia
This study looks at whether giving sedation (medicine to help you relax) during spinal anesthesia can reduce back pain after surgery. It's for people having certain types of surgery on their lower abdomen or legs.
Banhā, Qalyubia GovernorateAges 18–65 - NCT07163546Enrolling by invitation
Lifestyle redesign for chronic low back pain
This trial tests a person-centered lifestyle program to help people with chronic low back pain learn new ways to manage daily activities and reduce pain. It may be a good fit if you have had low back pain for at least 3 months and are looking for non-surgical support.
Ankara, AltındağAges 18–65 - NCT05894772Recruiting
Virtual portal program for youth waiting for chronic pain care
This study tests a virtual “stepped care” portal (a website/app) to help young people manage chronic pain while they’re waiting to start specialized care. It aims to see whether the portal improves support and outcomes during the wait time.
Halifax, Nova ScotiaAges 12–18 - NCT07178951Recruiting
Ultrasound-guided nerve treatment for knee osteoarthritis pain
This trial tests a non-surgical treatment that uses ultrasound to target nerves causing pain on the inner side of your knee due to osteoarthritis. It may help reduce pain and improve function for people with moderate to severe knee pain.
North York, OntarioAges 18 years+ - NCT07637084Recruiting
Light therapy for chronic pain and fatigue in Ehlers-Danlos Syndrome
This trial tests whether a non-invasive light therapy called photobiomodulation can reduce chronic pain and fatigue in people with hypermobile Ehlers-Danlos Syndrome (hEDS), a genetic condition affecting connective tissue. The light is applied to the skin and may help cells produce energy and reduce inflammation.
Boulogne-Billancourt, Île-de-France RegionAges 18 years+ - NCT06070766Recruiting
At-home ketamine study for chronic conditions
This trial tests a ketamine protocol you can use at home. It may help if you have a long-term health condition.
Bigfork, MontanaAges 18 years+ - NCT06297447Recruiting
Keeping it Simple: rehab for chronic pain
This study looks at how to better help people with ongoing muscle or joint pain who are getting rehabilitation through their local municipality. The goal is to learn what works best for you.
Holbæk, Region SjællandAges 18 years+ - NCT04439552Recruiting
MRI study during cornea cross-linking for keratoconus
This trial uses an MRI scan (and a close-up eye scan) to study what happens in the cornea during treatment for keratoconus. It may help doctors better understand how treatment works and who benefits most.
Boston, MassachusettsAges 8–35 - NCT06835868Recruiting
Registry for nerve stimulation treatments for chronic pain in Belgium
This trial creates a registry for people with chronic pain who are getting special nerve-modulating treatments in Belgium. It focuses on two specific chronic pain conditions: Persistent Spinal Pain Syndrome Type 2 (pain after spine surgery) and Complex Regional Pain Syndrome (a type of nerve pain).
Edegem, AntwerpAges Any age - NCT06351839Recruiting
Sleep better despite long-term pain
This trial tests a program to help people with chronic pain and insomnia sleep better. It focuses on combining pain management with sleep improvement strategies.
Tromsø, Troms CountyAges 18–75 - NCT07688876Recruiting
Comparing two treatments for long-term heel pain
This trial tests two minimally invasive procedures—pulsed radiofrequency and a dextrose injection—to see which better relieves chronic heel pain from plantar fasciitis that hasn't improved with other treatments.
AnkaraAges 18–70 - NCT05726331Recruiting
Tai chi and chiropractic for long-term neck pain
This trial looks at whether a program of tai chi and chiropractic care can improve chronic, non-specific neck pain and daily function. It may help people who have had neck pain for months and want a structured exercise-and-care approach.
Chestnut Hill, MassachusettsAges 18–65 - NCT07174609Recruiting
Scrambler therapy for chronic pancreatitis pain
This study tests a non-invasive pain treatment called scrambler therapy for people with chronic pancreatitis. It uses mild electrical signals on the skin to try to reduce long-term belly pain.
Baltimore, MarylandAges 18 years+ - NCT07675304RecruitingEarly Phase 1
Mesotherapy for chronic low back pain study
This trial tests whether injecting a natural substance (collagen) into the lower back can safely reduce chronic pain. It may help people with pain that hasn't spread to the legs.
WarsawAges 18–65 - NCT07629505Recruiting
CoQ10 supplement for chronic pelvic pain in men
This trial tests whether a CoQ10 supplement (Ralivia) can reduce chronic pelvic or perineal pain lasting at least 3 months. The study aims to see if this supplement helps relieve symptoms when other treatments haven't fully worked.
ThessalonikiAges 18–50 - NCT05764681Recruiting
Study for long-term pain after surgery
This study is for people who have chronic post-surgical pain and have a planned surgery on a leg or the spine. The goal is to better understand this long-term pain and what may help manage it after surgery.
Wilmington, DelawareAges 5–17 - NCT07308951Recruiting
Electrical acupoint stimulation for chronic cancer pain relief
This trial tests if a small, patient-controlled device that sends mild electrical pulses to acupoints (like acupuncture without needles) can improve quality of life for people with ongoing cancer pain. It may offer a drug-free way to manage pain at home.
Zhejiang, HangzhouAges 18–80 - NCT06454669RecruitingPhase 2
Dronabinol added to opioids for chronic low back pain
This trial tests whether adding dronabinol (a prescription medication derived from cannabis) to your current opioid pain treatment can help reduce chronic low back pain more effectively. It is for people who have had persistent low back pain for at least 3 months and are already on a stable opioid regimen.
Houston, TexasAges 18–64 - NCT03987334Recruiting
Virtual reality rehab for chronic neck pain
This trial studies whether virtual reality exercises can help reduce pain and improve function in people with chronic neck pain or whiplash. You may be invited to take part in guided VR rehab sessions if you meet the safety and health requirements.
Milan, MIAges 18–70 - NCT06106191Recruiting
Mindfulness program for chronic low back pain
This trial tests a mindfulness-based program designed to help people with long-term low back pain. It aims to see if combining mindfulness with a personalized approach can improve pain management and daily functioning.
Boston, MassachusettsAges 18 years+ - NCT05963451Recruiting
Testing treatments for long-term low back pain from facet joints
This study focuses on people with long-lasting low back pain that likely comes from the small “facet” joints in the lower spine. It aims to better understand brain, psychological, and biology changes to help optimize treatment for this type of back pain.
Sherbrooke, QuebecAges 18–75 - NCT07772141Recruiting
Palmitoylethanolamide for chronic low back pain
This trial tests whether a natural substance called palmitoylethanolamide (PEA) can help reduce chronic low back pain by calming the nervous system and reducing inflammation. It might be an option for people with ongoing pain from a disc problem who haven't had surgery.
Banī SuwayfAges 18–65
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 793 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.