Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 828 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06706479Enrolling by invitation
Brain stimulation for balance in older adults with back pain
This study tests whether a gentle, non-invasive electrical brain stimulation technique (called high-definition tDCS) can improve balance in older adults with chronic low back pain. Participants receive either real or sham stimulation during balance training sessions.
Hong Kong, Hong KongAges 60–85 - NCT07028034Recruiting
Six-minute step test for chronic back pain
This trial uses a simple step test to measure how chronic low back pain affects your daily function. It may help doctors better understand your condition without needing expensive equipment.
KırşehirAges 18–65 - NCT07719452Enrolling by invitation
Strengthening exercise for chronic low back pain
This study tests if adding a specific low back strengthening exercise to standard physical therapy helps people with long-lasting low back pain. It is for Tricare beneficiaries who have had back pain for at least 3 months without leg pain.
Fort Sam Houston, TexasAges 18–65 - NCT07241559Recruiting
Low back pain treatment study: injection and mobilization
This study tests two treatments for chronic low back pain: a special injection of dextrose (a sugar solution) guided by ultrasound, and a technique to mobilize the fascia (connective tissue) in the lower back. It aims to see if these help people who haven't found relief from standard treatments.
Ankara, AltındağAges 18–65 - NCT07684118Enrolling by invitation
Egoscue vs core exercises for chronic low back pain
This study compares two types of exercises—Egoscue and core stabilization—to help people with chronic low back pain and an exaggerated lower back curve. The goal is to find which approach better reduces pain and improves function.
Lahore, Punjab ProvinceAges 25–55 - NCT03836248Recruiting
Osteopathic care added to standard treatment for chronic low back pain
This study tests whether adding osteopathic treatment to usual medical care can improve chronic low back pain. It focuses on people whose back pain has no clear structural cause and has lasted more than 3 months.
ToulouseAges 18–64 - NCT07141069Recruiting
Art therapy for adults with chronic low back pain
This study tests whether making art (art therapy) can help adults with ongoing low back pain feel better. You would take part in art sessions to see if this approach reduces pain and improves your quality of life.
Hong Kong, Hong KongAges 18–59 - NCT07141082Recruiting
Art therapy for older adults with long-term back pain
This study tests whether expressive art therapy (like drawing, painting, or music) can help older adults manage chronic low back pain. It aims to reduce pain and improve quality of life without medication.
Hong KongAges 60 years+ - NCT01765777Recruiting
Osteopathic hands-on therapy and light treatment for long-term low back pain
This trial studies whether hands-on osteopathic treatment and a type of light (phototherapy) can reduce chronic low back pain. It may help people who have had non-specific low back pain for at least 3 months.
Old Westbury, New YorkAges 18–65 - NCT07463105Recruiting
Virtual reality vs. standard rehab for chronic back pain
This study compares virtual reality exercises to standard physical therapy for people with ongoing low back pain. It aims to see if VR can be a helpful and engaging way to reduce pain and improve function.
Sanok, Podkarpackie VoivodeshipAges 40–65 - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Birmingham, AlabamaAges 40 years+ - NCT06100822RecruitingPhase 1
Testing metformin for chronic Achilles tendon pain
This study tests whether a common diabetes medication, metformin, can help people with chronic Achilles tendon pain. If you have this condition and meet certain health requirements, you may be able to join.
Pittsburgh, PennsylvaniaAges 18–50 - NCT06360965Recruiting
Acupoint patch for pelvic pain after PID
This trial tests a skin patch treatment (acupoint application) placed on specific points of the body to help relieve ongoing pelvic pain from pelvic inflammatory disease. It may be a good option if you have moderate pain and ultrasound findings of tubal thickening or fluid.
BeijingAges 18–50 - NCT06891625Recruiting
Movement performance in people with chronic back pain
This study looks at how people with long-term back pain move. It aims to understand movement patterns in chronic back pain, which could help design better treatments.
HuddingeAges 18 years+ - NCT07118332RecruitingEarly Phase 1
Psilocybin for chronic pain in veterans who smoke
This trial tests if psilocybin can help veterans with chronic pain who also smoke cigarettes. You will take psilocybin in a controlled setting to see if it reduces pain and helps with smoking.
West Haven, ConnecticutAges 21–65 - NCT05667090Recruiting
High-dose vitamin D3 to ease chronic pain in dialysis patients
This study tests whether taking a very high dose of vitamin D3 can reduce moderate to severe chronic pain in people on hemodialysis. It may help by improving vitamin D-related pathways that could affect pain, but you must also meet specific health and testing requirements.
TaipeiAges 20 years+ - NCT05981105Recruiting
Recovery and Chronic Pain After Knee Replacement
This study tests a special recovery program after knee replacement surgery to see if it helps reduce long-term pain. You may be eligible if you are having a first-time knee replacement for osteoarthritis, are between 18 and 65, and live near the hospital.
New York, New YorkAges 18–75 - NCT06382272Recruiting
Bionic breast project to reduce chronic pain after mastectomy
This study tests a new device (a neuroprosthesis) placed during breast reconstruction to see if it can reduce long-term pain after a mastectomy. If you are having both breasts removed and plan to get tissue expander reconstruction, you may be able to join.
Chicago, IllinoisAges 18 years+ - NCT06841276Recruiting
Digital tool for chronic pain relief study
This study tests a smartphone device called QoLibri that helps manage long-term pain. You use it at home for a few weeks to see if it reduces pain and improves daily life.
NaillouxAges 18 years+ - NCT07561411Recruiting
Nerve blocks to reduce pain after breast removal surgery
This trial tests two types of nerve-blocking injections given during breast removal surgery to see which one better prevents long-term pain afterward. Both are given alongside general anesthesia and may help you recover with less chronic pain.
BeirutAges 18–80 - NCT06619171Enrolling by invitation
Teens with chronic pain: a study on distress
This study looks at why some teenagers with long-lasting chronic pain feel more distressed than others. It asks you to fill out a short survey on your phone every day for a period of time, to help researchers understand who is most at risk and when.
BathAges 12–19 - NCT05704751Recruiting
Test of targeted nerve stimulator placement for long-term back pain
This study tests a way to place and program a spinal cord stimulator to reduce long-term (chronic) back pain. It’s for people whose back pain has lasted at least 6 months and is severe enough to measure.
LondonAges 18–75 - NCT05894772Recruiting
Virtual portal program for youth waiting for chronic pain care
This study tests a virtual “stepped care” portal (a website/app) to help young people manage chronic pain while they’re waiting to start specialized care. It aims to see whether the portal improves support and outcomes during the wait time.
Halifax, Nova ScotiaAges 12–18 - NCT07198412Recruiting
Study on sedation's effect on back pain after spinal anesthesia
This study looks at whether giving sedation (medicine to help you relax) during spinal anesthesia can reduce back pain after surgery. It's for people having certain types of surgery on their lower abdomen or legs.
Banhā, Qalyubia GovernorateAges 18–65
Hear when a new Chronic pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 828 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.