Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 794 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06980948RecruitingPhase 1/Phase 2
Gene therapy study for nerve pain from small fiber neuropathy
This trial tests a new gene therapy called ST-503 for people with long-lasting nerve pain from small fiber neuropathy that hasn't improved with standard treatments. The study will check if the treatment is safe and tolerable.
Scottsdale, ArizonaAges 18 years+ - NCT07832318Recruiting
Herbal injection for chronic sciatica
This trial tests whether an herbal injection into acupuncture points can safely reduce leg pain from sciatica that has lasted more than 3 months. It compares this treatment to usual care, and may offer a new option for people who haven't found relief.
Bucheon-si, Gyeonggi-doAges 19–70 - NCT06413914Recruiting
CBT for long-term pain in rheumatic disease
This trial tests if cognitive behavioral therapy (a type of talk therapy that helps change pain-related thoughts and behaviors) can reduce long-term pain in people with rheumatic diseases. It also validates a new questionnaire (AE-FS) about how pain affects daily life.
OsloAges 18 years+ - NCT06637709Recruiting
Pain after osteoarthritis treatment: a 24-month study
This study looks at why some people still have pain after knee surgery or other treatments for osteoarthritis. It tests a marker in the blood to see if it relates to ongoing pain. You would be followed for 24 months.
Roma, RomaAges 18–99 - NCT07141108Recruiting
Using a digital tool to track chronic pain and improve quality of life
This trial tests a digital tool that helps you track your pain and activity level. The goal is to see if using the tool can improve your quality of life. You would use a smartphone or tablet app and share updates with your primary care team.
Malmö, Skåne CountyAges 18 years+ - NCT07285018RecruitingPhase 2
Study of a new drug for diabetic nerve pain in legs
This trial tests an investigational drug for people with pain caused by nerve damage from diabetes (diabetic peripheral neuropathy). It may help reduce pain in your lower legs if other treatments haven't worked well.
Birmingham, AlabamaAges 18 years+ - NCT06187038Recruiting
Pain education study for knee osteoarthritis
This trial tests if learning about chronic pain can help people with knee osteoarthritis feel better. You'll join a program that teaches you about pain and how to manage it.
São PauloAges 40–80 - NCT05183503Enrolling by invitation
Study of pain, stress, anxiety, and depression in jaw disorder
This study looks at how chronic jaw pain from temporomandibular disorder (TMD) relates to stress, anxiety, and depression in adults. Your results may help researchers better understand what affects symptoms and how people respond to care.
WroclawAges 18–80 - NCT07488936Recruiting
How low back pain types affect pain and quality of life after failed back surgery
This study looks at how different types of low back pain affect pain severity and quality of life in people who still have pain after back surgery. It aims to help doctors better understand and treat your pain.
Konya, SelçukluAges 18 years+ - NCT06084520Recruiting
Pain questionnaire study for opioid and non-opioid patients
This study tests two questionnaires for people with long-term pain. Researchers want to see if the tools work well for both those taking opioids and those who are not. Your answers can help improve pain care.
Uppsala, UpplandAges 18–75 - NCT07184463Recruiting
Pain reduction after lung surgery using different robot methods
This trial compares three ways to do robotic lung surgery to see which one causes less pain afterward. If you are having lung surgery, it may help your recovery be more comfortable.
Montreal, QuebecAges 18 years+ - NCT06406244Recruiting
TEAS for chronic pain after liver surgery
This trial tests whether a gentle, needle-free electrical stimulation on certain points on the body (called TEAS) can help reduce chronic pain after liver surgery and improve long-term survival. It may be a good option if you are scheduled for a liver removal and want to explore non-drug pain relief.
ChengduAges 18–80 - NCT06353789Recruiting
Teen Period Pain and Future Health
This study at the University of Oxford is looking at whether painful periods in teenagers can lead to long-term pain. You will be asked about your period pain and may have an MRI scan of your brain (safe, no radiation). The goal is to find ways to prevent chronic pain later in life.
Oxford, OxfordshireAges 11–20 - NCT07837102Recruiting
Mobile app for monitoring chronic pain
This study tests a mobile app that helps you manage chronic pain by monitoring your symptoms from home. If you have chronic pain syndrome (including fibromyalgia) and a smartphone, this trial might help you track your pain and stay connected with your care team.
Hackensack, New JerseyAges 18 years+ - NCT07776600Recruiting
Pain coaching by text or phone for veterans
This study tests a text or phone chatbot that offers pain coaching to veterans with chronic pain. It may help you manage your pain and avoid extra clinic visits.
Augusta, GeorgiaAges 18 years+ - NCT07756541Recruiting
Online music and movement program for chronic pain
This study tests whether an online program combining music and gentle movement can help reduce chronic pain. It uses sessions you can do at home with your own device.
Cleveland, OhioAges 18 years+ - NCT07688902Recruiting
Comparing two injection methods for partial rotator cuff tears
This study compares two ways of injecting a sugar-water solution (5% dextrose) into the shoulder to treat partial rotator cuff tears. It may help reduce pain and improve shoulder function without surgery.
AnkaraAges 18–75 - NCT07696923Recruiting
Treating frozen shoulder with microembolization or steroid injection
This trial compares two treatments for frozen shoulder: a new procedure that blocks tiny blood vessels (TAME) and a steroid injection. You must have had shoulder pain for at least a month and be willing to do physical therapy.
TaipeiAges 18–80 - NCT07677540Recruiting
Nerve blocks before chest surgery to prevent long-term pain
This study is looking at two different types of nerve blocks—one called an erector spinae block and one called thoracic epidural—given before chest surgery to see if either can help prevent long-term pain after the operation.
Kfar SabaAges 18–99 - NCT07642882Recruiting
Brain Stimulation for Fibromyalgia Pain Relief
This study tests whether a non-invasive brain stimulation treatment (rTMS) can reduce chronic pain in fibromyalgia patients. The treatment uses magnetic pulses to stimulate specific areas of the brain and may help relieve widespread pain.
Boulogne-Billancourt, Île-de-France RegionAges 18–80 - NCT07575555Recruiting
Lipedema's role in knee arthritis in women
This study compares women with knee arthritis who do or don't have lipedema (a condition causing painful fat buildup, usually in the legs) to understand how lipedema affects knee joint health. Results may help doctors better treat knee arthritis in women with lipedema.
Izmir, İzmirAges 30–65 - NCT07555314Recruiting
Outpatient Catheter for Lidocaine Pain Treatment
This trial tests using a special catheter (thin tube) to deliver lidocaine—a numbing medication—to treat chronic pain on an outpatient basis. Researchers want to see if this approach helps manage long-term pain effectively.
WarsawAges 18 years+ - NCT07544914Recruiting
Magnetic Stimulation for Elbow and Wrist Chronic Pain
This study tests whether a non-invasive magnetic therapy applied to the skin can reduce chronic pain from tennis elbow, golfer's elbow, or carpal tunnel syndrome. The treatment uses magnetic pulses to stimulate nerves and may help relieve pain without medication or surgery.
Winnipeg, ManitobaAges 18 years+ - NCT07538427Recruiting
Music Therapy for Health in Rural Elder Care
This study explores whether music can improve health and wellbeing in older adults living in rural care facilities. Researchers will work with residents to understand how music might help with mood, memory, and quality of life.
Flagstaff, ArizonaAges Any age
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 794 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.