Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 828 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05811312Recruiting
Spinal cord stimulation and brain changes in chronic pain
This study uses non-invasive brain monitoring to see how spinal cord stimulation may change brain activity in people with chronic nerve pain. It aims to better understand how treatment affects the brain and pain over time.
Cleveland, OhioAges 18 years+ - NCT06139510Recruiting
Understanding Pain in Sickle Cell Disease
This study looks at what causes pain in people with sickle cell disease. They hope to learn more about pain patterns to better help patients manage it.
Durham, North CarolinaAges 15–40 - NCT06327542Recruiting
Group pain management in primary care clinics
This trial tests a group-based program to help people with chronic pain manage their symptoms. It is offered in primary care clinics that serve underinsured communities, and sessions are available in English or Spanish.
San Francisco, CaliforniaAges 18 years+ - NCT06582134Recruiting
Mindfulness for jaw pain in university students
This trial tests whether brief mindfulness exercises can help reduce jaw pain in university students. If you have had jaw pain for at least 3 months, you may be able to join.
Kuala Lumpur, Kuala LumpurAges 18–30 - NCT07541599Recruiting
Mind-Body Skills for Rural Veterans With Chronic Pain
This study tests whether online mind-body techniques (like meditation and breathing exercises) can help rural veterans manage chronic pain. You'll attend remote sessions and learn skills to reduce how much pain interferes with daily life.
Minneapolis, MinnesotaAges 18 years+ - NCT06405646Enrolling by invitation
Cannabidiol and Cannabinol for Chronic Jaw Muscle Pain
This study tests whether certain compounds from the cannabis plant (CBD and CBN) can help relieve long-term pain in the jaw muscles. It is for adults with chronic orofacial pain who have not recently taken medications that affect the nerves or muscles.
WroclawAges 18–80 - NCT07418632Recruiting
Motion training for neck pain using smart classification
This study tests a special motion-training program for people with neck pain. It uses a computer to classify and guide your movements, which may help reduce pain better than usual care.
LjubljanaAges 18–65 - NCT07150143Recruiting
Massage and exercises for chronic neck pain
This trial tests whether adding a special type of massage (connective tissue massage) and other physical therapies to standard neck stabilization exercises helps people with long-term neck pain feel better.
Ataşehir, IstanbulAges 18–65 - NCT06240299Recruiting
Neurofeedback for chronic pain in rheumatoid arthritis
This trial tests a brain-training technique called neurofeedback to see if it can help people with rheumatoid arthritis who also have chronic widespread pain. It uses a computer to show you your brain activity and teach you to control it, which may reduce pain.
Glasgow, ScotlandAges 18–75 - NCT06932406Recruiting
Personality and self-help for jaw pain
This study tests whether a self-management program for jaw and face pain works differently in people with different personalities. You will learn techniques to manage your pain at home.
Valencia, ValenciaAges 18–65 - NCT06946290Recruiting
Nerve block for pain relief after heart surgery
This study tests a nerve block, called an intertransverse process block, to see if it helps people feel better and recover faster after heart surgery. The block is given during surgery to reduce pain.
Hong KongAges 18 years+ - NCT06652724Recruiting
Psychological help for chronic pain in fibromyalgia and migraine
This study looks at how psychological factors and treatments might help with chronic pain in people with fibromyalgia and/or chronic migraine. It compares different groups to understand what works best.
Rome, RMAges 18–50 - NCT06212349Recruiting
Physiotherapy for pain and quality of life in endometriosis
This trial tests a combined therapy and education program for women with endometriosis. It aims to reduce pelvic pain, improve muscle function, and enhance quality of life. If you have persistent pelvic pain and certain muscle issues, this study may help.
ValenciaAges 18–45 - NCT07426562Recruiting
Stretching vs. Dry Needling for Tight Hamstrings in Chronic Back Pain
This trial tests two treatments for tight hamstrings in people with long-lasting low back pain: a special stretch and dry needling (thin needles placed in trigger points). It aims to find which helps reduce tightness and pain.
Peshawar, Khyber PakhtunkhwaAges 20–50 - NCT07474610Recruiting
Belly muscle and arm function in chronic low back pain
This study looks at how a deep belly muscle (transversus abdominis) relates to arm and shoulder function in people with long-term low back pain. It may help understand why some people have trouble with upper body movements.
AnkaraAges 18–45 - NCT04074798Recruiting
Breathing over fast and slow movements for back pain
This study tests how breathing changes (hyperventilation) might affect people with long-lasting low back pain. It may help researchers understand triggers or symptoms, and compare them to people who do not have back pain.
HasseltAges 20–60 - NCT04164225Recruiting
Testing how qigong affects brain activity in chronic low back pain
This study looks at how doing qigong may change brain activity and physical symptoms in adults with long-lasting low back pain. It’s mainly to see whether the brain and symptom measures can be identified and tracked after qigong practice.
Minneapolis, MinnesotaAges 18–70 - NCT05231265Recruiting
Lumbar surgery effect on walking complexity in chronic low back pain
This study looks at how lumbar spine surgery (fusion or artificial disc “prosthesis” on one or two levels) affects how complex your walking looks and feels. It may help doctors better understand what to expect from surgery and how it changes movement in people with long-term low back pain.
NîmesAges 18 years+ - NCT05480982Recruiting
Cognitive functional therapy versus Pilates for low back pain
This study compares two exercise-based approaches—cognitive functional therapy and Pilates—to help reduce chronic low back pain in older adults. It may help by improving how you move and manage pain, not just stretching muscles.
Rio de Janeiro, Rio de JaneiroAges 65 years+ - NCT05607381Recruiting
Meditation program study for opioid-treated chronic low back pain
This trial studies how meditation may change brain activity and help people with long-lasting low back pain who are already taking prescription opioids. The goal is to understand the “neural” (brain) effects of meditation to improve pain treatment.
La Jolla, CaliforniaAges 18–65 - NCT06656156Recruiting
Stretching technique for chronic low back pain relief
This trial tests a physical therapy stretching method called PNF on the hip and hamstring muscles to see if it reduces chronic low back pain. It may help if you have had non-specific low back pain for over 3 months with tightness in your hips or legs.
Karachi, SindhAges 15–40 - NCT06928597Recruiting
GPR therapy for chronic low back pain
This study tests a physical therapy method called Global Postural Re-education (GPR) for people with long-term low back pain that is not caused by a specific disease. It aims to see if GPR can help reduce pain and improve function.
Salvador, Estado de BahiaAges 18–55 - NCT07026045Recruiting
Stretching techniques for chronic low back pain
This trial compares two gentle stretching techniques to see which one better eases chronic low back pain. It may help if you have had ongoing pain for months and are looking for a non-surgical treatment.
Lahore, Punjab ProvinceAges 18–45 - NCT07051772Recruiting
Predicting success in back pain rehab
This study looks for factors that help people with long-term low back pain succeed in rehabilitation programs. Researchers will track participants during their rehab to learn what works best.
Clermont-Ferrand, AuvergneAges 18–65
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 828 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.