Clinical trials
Cigarette Smoking clinical trials
Below are recruiting cigarette smoking clinical trials, each written for real people, not researchers. We’re tracking 81 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07142668Recruiting
How cigarette cost and availability affect tobacco buying
This study looks at how changing cigarette prices and availability affects what and how much tobacco people buy. It may help inform future policies that aim to reduce smoking.
Buffalo, New YorkAges 21 years+ - NCT05815199Recruiting
E-cigarettes to help smokers with serious mental illness cut down
This study tests whether e-cigarettes can help people who smoke a lot reduce cigarette use (without requiring them to quit completely). It is designed for adults with serious mental illness and focuses on harm reduction and follow-up over time.
New York, New YorkAges 21 years+ - NCT05008848RecruitingPhase 3
Text message program to help rural cancer survivors quit smoking
This trial studies a text-message based program to help people who smoke quit. It targets adults in rural areas who are currently in cancer treatment and want support stopping smoking.
Kingman, ArizonaAges 18 years+ - NCT06232447Recruiting
Menthol smoking and inflammation study
This study looks at how menthol cigarettes affect inflammation and smoking habits. It uses a smartphone app to track your experiences and may help find better ways to help people quit.
North Chicago, IllinoisAges 21–85 - NCT05836103Recruiting
Texting on your phone to help you quit smoking
This trial tests whether smartphone texting messages can help young adults stop smoking. If you’re planning to quit soon, the messages may support you during the quitting process.
Baltimore, MarylandAges 18–30 - NCT07111234Recruiting
Studying flavored nicotine pouches to understand user preferences
This study tests different flavors and cooling agents in oral nicotine pouches to see which ones people prefer. It may help develop safer alternatives for people who currently smoke cigarettes.
Columbus, OhioAges 21 years+ - NCT06787937Recruiting
Study on reducing nicotine in cigarettes
This study tests cigarettes that have less nicotine to see how people react to them. You may be able to join if you are a regular adult smoker interested in trying reduced-nicotine cigarettes.
Atlanta, GeorgiaAges 21 years+ - NCT04903028Recruiting
Brain stimulation to help people quit smoking
This study tests whether a type of brain stimulation (rTMS) can help people stop smoking. It targets brain circuits involved in cravings, aiming to support quitting safely.
Charleston, South CarolinaAges 22–70 - NCT06678789Recruiting
Testing low vs high nicotine pouches for smokers
This study compares how low and high nicotine pouches affect adult smokers who want to try a tobacco-free option. You'll attend two visits in Charleston to check health markers.
Charleston, South CarolinaAges 21 years+ - NCT06609083RecruitingPhase 1
How cannabis affects cigarette smoking
This study looks at how cannabis affects cigarette smoking habits. If you smoke every day and also use cannabis weekly, researchers want to see if cannabis changes how much you smoke.
Baltimore, MarylandAges 21 years+ - NCT05896033Recruiting
Study how menthol cigarette rules affect current menthol smokers
This study looks at how changes in menthol cigarette and e-cigarette rules may affect people who currently smoke menthol cigarettes. You may be asked to complete phone-based reports (like a diary) about your smoking patterns.
Charleston, South CarolinaAges 21 years+ - NCT06072547Recruiting
Can flavored nicotine pouches help you smoke less?
This study tests if flavored nicotine pouches can help adults who smoke at least 5 cigarettes a day switch away from smoking. You'll use the pouches instead of cigarettes, and researchers will track your smoking habits.
Raleigh, North CarolinaAges 22–65 - NCT07089901RecruitingPhase 4
Smartphone app to help you quit smoking
This study uses a smartphone app and a breath carbon monoxide monitor to help people understand their smoking patterns and quit. It tests a digital approach to quitting, and you'll get support with nicotine replacement therapy if eligible.
Durham, North CarolinaAges 21 years+ - NCT04783857RecruitingPhase 4
Hormone therapy to prevent smoking relapse after childbirth
This trial tests whether giving progesterone after childbirth can help new mothers stay quit from smoking, reducing secondhand smoke exposure to their babies. It's for women who smoked before pregnancy and want to remain smoke-free after delivery.
Minneapolis, MinnesotaAges 18–45 - NCT06173778RecruitingPhase 2
Semaglutide for weight management after quitting smoking
This study tests whether the drug semaglutide (often used for weight loss) can help people who quit smoking avoid gaining weight. It's for people who are overweight or have weight-related health issues and want to stop smoking.
Austin, TexasAges 18–75 - NCT06754215Recruiting
Smoking Cessation Program for Homeless Youth
This study is testing a new program to help homeless youth quit smoking. The goal is to learn what kind of support works best for young people who don't have stable housing.
Columbus, OhioAges 14–24 - NCT07710820Recruiting
Can a heated tobacco product help you stop smoking?
This study tests whether having access to a heated tobacco product (a device that heats tobacco, not burns it) helps current cigarette smokers quit smoking. You'll try four different flavors over a week and then continue using one you like.
Brandon, FloridaAges 21–65 - NCT07223840RecruitingPhase 2
A study of brenipatide to help former smokers stay smoke-free
This trial tests an injectable drug called brenipatide to see if it helps people who have recently quit smoking stay quit for good. The study follows participants over time and requires them to come to clinic visits.
Rogers, ArkansasAges 18–75 - NCT07014124Recruiting
Helping smoking fathers quit for their sick child
This study tests whether helping smoking fathers quit can improve their child's health. You and your child will get support through a messaging app, and the child will provide saliva samples.
Hong Kong, PokfulamAges 18 years+ - NCT04604509RecruitingPhase 4
Smoking quit plan using counseling and nicotine-free medicines
This trial tests whether a quit program that combines counseling with medicines (nicotine replacement, varenicline, or bupropion) helps people stop or cut down smoking. It’s also delivered through telehealth, with repeated check-ins to see how well the plan works and whether it’s safe for you.
Houston, TexasAges 18 years+ - NCT06948058Recruiting
E-cigarettes vs nicotine therapy for quitting smoking in obesity
This study compares e-cigarettes and nicotine replacement therapy (like patches or gum) to help people who are obese quit smoking. Participants use a study product for 8 weeks and track progress with a smartphone app.
Providence, Rhode IslandAges 21 years+ - NCT03514602Recruiting
Help quitting smoking to prevent childhood obesity
This study supports pregnant people who smoke to quit or cut down, using behavior-based coaching. It also measures how changes in smoking may help lower a child’s risk of developing obesity.
Buffalo, New YorkAges 18–39 - NCT05233228RecruitingPhase 2
Phone-based coaching to help you quit smoking in Laos
This study tests a mobile phone program that gives personalized help to support quitting smoking. If you’re eligible, it may help you plan a quit date and stick with quitting using the app.
ChampasakAges 18–65 - NCT07661550Recruiting
Preventing smoking relapse after pregnancy with breastfeeding help
This trial tests whether breastfeeding support can help you stay smoke-free after your baby is born. You may join if you quit smoking during this pregnancy and want to learn more about caring for your baby and breastfeeding.
Buffalo, New YorkAges 18 years+
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Common questions
- Are there clinical trials for cigarette smoking?
- Yes. Clin2 currently lists 81 recruiting cigarette smoking studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cigarette smoking trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cigarette smoking trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.