Clinical trials
Cigarette Smoking clinical trials
Below are recruiting cigarette smoking clinical trials, each written for real people, not researchers. We’re tracking 81 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07119489Recruiting
Group therapy to help cancer patients quit smoking
This trial tests a new type of group therapy (based on dialectical behavior therapy) to help cancer patients quit smoking. It is designed for patients who currently smoke and want to learn coping skills to stop.
Charlotte, North CarolinaAges 18 years+ - NCT07039292Enrolling by invitation
Can e-cigarettes help reduce smoking?
This study tests whether e-cigarettes can help people who smoke but have not wanted to use other treatments. If you currently smoke and have declined traditional options like nicotine patches or quitlines, you may be able to join.
Charleston, South CarolinaAges 21 years+ - NCT06395415Recruiting
Mobile health program for young adult e-cigarette users
This study tests a mobile health program to help young adults ages 18–26 who use e-cigarettes regularly to reduce or quit. It uses text messages to support you, and you'll need to be interested in changing your vaping habits.
Chicago, IllinoisAges 18–26 - NCT07167225Recruiting
E-cigarette and cannabis co-use in young adults
This study looks at how using e-cigarettes and cannabis together affects exposure to harmful chemicals in young adults aged 18-25. It aims to understand the risks of co-use to help guide healthier choices.
Buffalo, New YorkAges 18–25 - NCT06763536Recruiting
Comparing nicotine pouches vs. nicotine patches or gum to help smokers in rural Appalachia quit
This study tests if oral nicotine pouches work better than nicotine patches or gum to help you smoke less. You’ll use one of these products for a while and check in with the study team. This is for adults who live in rural Appalachian counties and smoke at least 5 cigarettes a day.
Columbus, OhioAges 21 years+ - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75 - NCT06296849RecruitingPhase 2
Quit smoking together as a couple with financial incentives
This trial tests if offering money rewards can help couples who both smoke to quit together. You and your partner would both join the program and get support to stop smoking.
Athens, GeorgiaAges 18 years+ - NCT05019495Recruiting
Study to improve quit-smoking support for people with HIV
This trial tests ways to deliver tobacco-quit treatment more effectively for people living with HIV. You may help researchers compare different quit-support approaches to see what works best.
Charleston, South CarolinaAges 21 years+ - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT05642715Recruiting
HIV smoking reduction program with varenicline and online support
This study tests a harm-reduction approach to help people with HIV smoke fewer cigarettes and quit if they want, using an online tobacco program and varenicline (a quit-smoking medicine). You may be placed in one of two different study groups to compare how well the approaches work.
The Bronx, New YorkAges 40–79 - NCT07221214RecruitingPhase 2
Testing a diabetes drug for drinking and heart health in HIV
This trial tests if a once-weekly diabetes medication (semaglutide) can help people with HIV reduce heavy drinking and improve heart health. It's for people who drink alcohol and have a higher body weight.
Nashville, TennesseeAges 18–89 - NCT07482475Recruiting
COPD study for people getting lung cancer screening
This study looks at COPD in people who are already getting lung cancer screening. If you have COPD or a high risk for it, joining this observational trial may help researchers learn more about your condition.
Ann Arbor, MichiganAges 50–80 - NCT07547202Recruiting
Gum Disease Treatment Effects on Saliva in Smokers and Non-Smokers
This study tests whether a non-surgical cleaning procedure for gum disease changes markers in your saliva differently depending on whether you smoke. Researchers want to understand how smoking affects how your mouth heals.
Baghdad, Baghdad GovernorateAges 18 years+ - NCT06474299RecruitingPhase 4
Quit Smoking and Vaping With Patches and Pills
This study tests whether a combination of a nicotine patch plus a medication called varenicline can help people who both smoke and vape quit both. You'll get free medication and support to help you stop.
Madison, WisconsinAges 21 years+ - NCT07455513Recruiting
Smoking cessation help for people with lung cancer
This study tests a new resource to help smokers who have or may have lung cancer quit smoking. The goal is to see if this resource makes it easier to stop smoking.
Columbus, OhioAges 21 years+ - NCT05121051RecruitingPhase 2
Broccoli sprout extract to reduce tobacco cancer-causing chemicals
This Phase 2 study tests whether broccoli sprout extract (Avmacol ES) can reduce cancer-causing substances linked to heavy smoking. It’s for adults who smoke heavily and may help lower harmful tobacco-related chemical effects in the body.
Tucson, ArizonaAges 18 years+ - NCT07439471Recruiting
Study on tobacco and cannabis co-use in young adults
This study looks at why and how young adults use both tobacco and cannabis together. It may help understand patterns of use and improve future health programs.
Buffalo, New YorkAges 18–30 - NCT07108166Recruiting
COPD and Chronic Bronchitis: Switching from Cigarettes to Heat-Not-Burn Device
This study tests whether switching from regular cigarettes to a heated tobacco device (a product that heats rather than burns tobacco) can improve symptoms and lung function in people with moderate COPD and chronic bronchitis. Participants will be randomly assigned to either switch to the heated device or continue smoking cigarettes.
Clearwater, FloridaAges 40 years+ - NCT06922617Recruiting
E-cigarettes vs. Nicotine Replacement for Smoking in Substance Use Treatment
This study compares e-cigarettes to nicotine replacement therapy (like patches or gum) to help people who are in treatment for substance use disorder (like drugs or alcohol) quit or reduce smoking. It aims to find a safer way to cut back on cigarettes.
Charleston, South CarolinaAges 21 years+ - NCT05703672RecruitingPhase 3
Switching smokers to e-cigarettes who do not want to quit
This study tests whether switching from regular cigarettes to e-cigarettes helps smokers who are not interested in quitting. You would also be offered varenicline and regular check-ins to compare outcomes over time.
Kansas City, MissouriAges 21 years+ - NCT06617312RecruitingPhase 2
Cytisinicline and brain response to smoking cues
This study tests how a medicine called cytisinicline (similar to a plant-based stop-smoking aid) affects brain activity when you see or think about smoking. It may help researchers understand how the medicine works, even if you aren't ready to quit right now.
Los Angeles, CaliforniaAges 18–65 - NCT05772845Recruiting
Study of quitting support for vaping and smoking withdrawal
This study looks at nicotine withdrawal symptoms in people who vape and/or smoke regularly. It may help improve how quitting support is tailored, based on how participants respond during the withdrawal period.
Buffalo, New YorkAges 21–50 - NCT05555069Recruiting
Menthol-flavored vaping study for adult menthol cigarette smokers
This study looks at how menthol flavoring may affect whether adult menthol cigarette smokers switch to e-cigarettes. You may be asked to switch and use e-cigarettes over a set period, while researchers track your smoking behavior.
Kansas City, MissouriAges 21 years+ - NCT05665465RecruitingEarly Phase 1
Study how childhood stress may affect future smoking risk
This early study looks at how experiences from childhood may affect brain and behavior patterns related to nicotine and smoking risk. It may help researchers design better prevention strategies for people who have never smoked.
Durham, North CarolinaAges 18–21
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Common questions
- Are there clinical trials for cigarette smoking?
- Yes. Clin2 currently lists 81 recruiting cigarette smoking studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cigarette smoking trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cigarette smoking trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.