Cognition Disorders in Old Age clinical trials

Brain Stimulation to Help Thinking in Schizophrenia

This trial tests a non-invasive brain stimulation technique called transcranial electrical stimulation (TIS) to improve thinking and memory problems in people with schizophrenia. Researchers want to see if this treatment, combined with antipsychotic medications, can help you think more clearly and function better in daily life.

Cognitive behavior therapy for acute insomnia

This trial tests if a specific type of talking therapy called analytic-integrative cognitive behavioral therapy can help people with new-onset insomnia (trouble sleeping for less than 3 months). It aims to improve sleep quality and reduce stress related to sleep problems.

Brain scan study for sleep in older Chinese adults

This study uses brain scans to understand sleep problems in older Chinese adults. If you are 60+ and have trouble sleeping, you may help researchers find better ways to improve sleep.

Recovery after ICU: a long-term study

This study follows people after they leave the ICU to see how they recover over time. It uses computer programs to find patterns and create early warning tools to help doctors spot problems sooner.

Study Protocol: The Efficacy of Mushroom to Reduce Cognitive Decline in At-Risk Middle-aged Adults and Young-olds Living in the Community

Cognitive recovery after ICU delirium

This study follows patients who experienced delirium in the ICU to track how their thinking and memory recover over time, and what factors might help or hinder that recovery.

Sound therapy for memory loss in older adults

This study tests whether listening to a special sound (gamma-frequency tones) can help slow down memory loss in older adults. It's for people who have mild memory problems but not dementia or other brain disorders.

Electrical stimulation and light resistance training for older adults' muscles

This study tests whether combining electrical muscle stimulation (a gentle electrical current applied to muscles) with light resistance exercises can help adults over 65 build stronger leg muscles and improve their ability to walk and move around.

Fall prevention program for community seniors

This trial tests a fall prevention program for older adults living in the community. It aims to help you learn how to reduce your risk of falling and stay safe on your feet.

Exercise program for seniors who want to be more active

This study helps adults 65 and older who are not very active to start a safe, moderate-intensity exercise program. It focuses on whether exercising at home with guidance can improve health and fitness.

Brain scan and stimulation study for kids with mild concussion

This study tests whether a brain “stimulation” approach, paired with brain imaging (MRI), can help children who still have symptoms after a mild concussion. There is also a comparison group of children without concussion history.

Carbon dioxide and brain waste clearance trial

This trial tests if breathing in carbon dioxide helps the brain clear waste. It may show how the brain heals after a traumatic brain injury (TBI).

Binaural beats for memory in older adults with mild cognitive impairment

This trial tests whether listening to special sounds called binaural beats can help older adults with mild memory or thinking problems improve their cognitive function. If you live in a nursing home and have mild cognitive impairment (not dementia), you may be able to join.

Validating psychosis assessment tools in Lithuanian

This trial tests whether three psychiatric questionnaires work well for people with schizophrenia or related disorders. If you are between 18 and 65 and have one of these diagnoses, joining may help improve care for others like you.

Ultra-processed food, behavior, and thinking in teens

This study looks at how eating a lot of ultra-processed foods affects behavior, attention, and thinking in kids 10-15 years old. It may help understand if diet is linked to issues like ADHD or learning problems.

Reminiscence therapy for older adults

This study tests whether reminiscence therapy (looking back on positive memories) helps improve well-being in older adults. It may be a good fit if you are 65 or older and free from serious mental health issues or dementia.

Study of brain activity during thinking using electrode recordings

This Phase 1 study records electrical signals from the brain while you perform thinking tasks. The goal is to better understand how human brain circuits work during cognition, and the study may help future treatments.

Walking while thinking in kids with coordination disorder

This study looks at how walking and thinking at the same time (dual-tasking) affects children with Developmental Coordination Disorder (DCD). It may help understand why multitasking can be harder for some kids and lead to better support strategies.

Mindfulness for heart-brain health in adults 50-70

This study tests whether a daily mindfulness practice can help older adults improve how their heart and brain work together. You will do breathing exercises at home and come to USC twice for check-ups, including blood and urine tests and an MRI.

MitoQ supplement for early psychosis

This study tests whether a supplement called MitoQ can help people with early-stage psychosis by improving how their cells produce energy. If you are younger and have been treated for psychosis for less than 5 years, this trial may be an option for you.

Cognitive rehab for anger in Veterans with TBI and PTSD

This study tests a cognitive rehabilitation program to help Veterans with TBI and PTSD manage anger. You and a trusted support person will participate together to learn skills to reduce anger and improve thinking.

Creatine supplement study for healthy middle-aged women

This study is testing a creatine supplement (a substance that may help with energy and muscle function) in healthy middle-aged women. You may join if you are between 35 and 65, a non-smoker, and have a certain activity level.

Boosting positive feelings for people with alcohol use disorder

This study tests a program designed to help people with alcohol use disorder who also struggle with low mood or anxiety. It aims to increase positive emotions, which may make it easier to reduce drinking.

Time-restricted eating and low glycemic diet for menopause

This study tests if combining time-restricted eating with a low glycemic index diet can improve memory, slow aging, and boost metabolism in women going through perimenopause or menopause. It aims to see if this eating pattern helps with brain health and body changes during this life stage.