Clinical trials
Cognitive Decline clinical trials
Below are recruiting cognitive decline clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07286448Recruiting
Digital Brain Training for Mild Memory Problems
This trial tests a personalized digital brain training program for people with mild memory or thinking problems. It aims to see if the training can boost cognitive fitness and help maintain your thinking skills.
Modena, Reggio Nell'Emilia (RE)Ages 50 years+ - NCT05998031Recruiting
Testing brain stimulation for memory in mild memory loss
This study tests if a gentle brain stimulation technique called tDCS, combined with memory training, can help older adults with mild cognitive impairment (MCI) improve their working memory. You'll have MRI scans and attend training sessions.
Gainesville, FloridaAges 60–95 - NCT06452147Recruiting
Anesthesia and brain health after hip surgery in older adults
This trial is testing different types of anesthesia to see how they affect brain function (memory, thinking) after hip fracture surgery in older adults. It aims to find the safest approach for elderly patients.
Wenzhou, ZhejiangAges 65 years+ - NCT06870136Recruiting
Lion's Mane supplement for memory and focus
This study tests a Lion's Mane supplement to see if it helps with memory, focus, and overall thinking. If you are between 40 and 75 and have mild concerns about your thinking, you may be able to take part.
Los Angeles, CaliforniaAges 40–75 - NCT06933095Recruiting
DHA supplement study for older adults with mild memory concerns
This study tests whether a DHA (omega-3) supplement can improve delivery of certain brain fats in older adults who have mild memory concerns. It involves taking a daily supplement and may include a lumbar puncture (spinal tap).
Cincinnati, OhioAges 55–82 - NCT07457138Recruiting
Brain health study for people with memory worries
This study looks at people who are worried about their memory or thinking skills, even if tests show no problems. It aims to understand brain health over time in a Lombardy clinic.
Costa Masnaga, LombardyAges 18 years+ - NCT07168824Enrolling by invitation
Can a probiotic improve memory in adults with mild cognitive decline?
This trial tests whether a daily probiotic called Lacticaseibacillus paracasei PS23 can help improve thinking and memory in adults aged 50 to 85 who feel their memory is slipping but do not have dementia or Alzheimer's disease.
TaoyuanAges 50–85 - NCT07332299Recruiting
Brain stimulation and training for seniors with TBI
This study tests if a wearable brain stimulation device (tDCS) combined with computer-based training can improve attention and concentration in older veterans with a history of mild brain injury. It involves several sessions from home using a headset and computer.
Minneapolis, MinnesotaAges 65 years+ - NCT06268080Recruiting
Sedation depth and mental recovery after surgery for older adults
This trial tests whether monitoring how deeply you sleep during anesthesia helps prevent confusion and memory problems after surgery. It is for older adults who can give consent and are having a major operation.
Grafton, AucklandAges 55 years+ - NCT03402919Recruiting
Brain and memory study for people with thinking changes
This study looks at memory and thinking changes using questionnaires, memory testing, and brain scans. It may help researchers better understand neurodegeneration and dementia and how these problems show up over time.
Calgary, AlbertaAges 50–90 - NCT06539403Recruiting
Thinking about memory and confidence with age
This study asks people who have been referred to a memory clinic about how they feel about their memory and memory changes with age. It aims to understand how confident you are in your memory and how that might shift over time.
LondonAges 65–120 - NCT06561906Recruiting
Early Alzheimer's detection using scans, genetics and blood
This study uses brain scans, blood tests, and genetic information to find early signs of Alzheimer's disease before memory problems start. It aims to predict who might develop Alzheimer's in the future.
Nanjing, JiangsuAges 50–79 - NCT07531888Enrolling by invitation
Brain Stimulation to Improve Memory in Older Adults
This study tests whether a non-invasive brain stimulation technique (tDCS) can help improve memory and thinking skills in people aged 60–75 who have noticed mild memory problems. You'll receive either real or sham (placebo) stimulation and undergo cognitive training over several weeks.
Pachuca, HidalgoAges 60–75 - NCT07212504Recruiting
Brain stimulation to improve memory in older adults with mild memory problems
This study tests a new type of brain stimulation called accelerated neuromodulation, aimed at improving memory and thinking in older adults with mild memory issues. It uses magnetic pulses to gently stimulate a part of the brain linked to memory.
Toronto, OntarioAges 55–85 - NCT07213700Recruiting
Long-term study on Alzheimer's disease
This study follows people who are either being evaluated for Alzheimer's disease or have already been diagnosed. Researchers want to track their health over many years to better understand the disease and how treatments affect it.
GrazAges Any age - NCT07589595RecruitingPhase 2
Donanemab for Early Cognitive Decline with Lewy Bodies
This study tests donanemab, an investigational drug designed to target amyloid proteins in the brain that may contribute to cognitive decline in people with early dementia with Lewy bodies. The trial aims to see if this treatment can slow cognitive decline and help preserve thinking and memory.
Chandler, ArizonaAges 55–85 - NCT07731191Recruiting
Digital tools to predict Alzheimer's risk factors
This study uses smartphone tools to track early signs of Alzheimer's by analyzing risk factors. It is for people with mild cognitive issues (MCI) or subjective cognitive decline (SCD) who do not have dementia.
Brescia, BSAges 18 years+ - NCT07422220Recruiting
Walnuts and brain health: a long-term study
This study tests whether eating walnuts every day for a long time can help keep your brain healthy as you age. It is for middle-aged and older adults who carry extra weight around their belly but are otherwise generally healthy.
Maastricht, LimburgAges 45–75 - NCT05155137RecruitingPhase 3
Daily pill and home risk check to prevent stroke and memory loss
This Phase 3 trial tests whether a daily “polypill” plus a simple home risk-check plan can lower the chance of stroke and future thinking/memory problems. It is aimed at adults at moderate risk but who have not had stroke or heart disease before.
Porto Alegre, Rio Grande do SulAges 50–75 - NCT06889818Recruiting
Alzheimer's treatment and diagnostics registry study
This study creates a registry for people who are using newly approved Alzheimer's medications. It tracks how these treatments work over time and may help researchers learn more about diagnosing and treating Alzheimer's.
IncheonAges 19 years+ - NCT07236190RecruitingPhase 2
Using brain markers to test NPC-1 for Alzheimer's
This trial tests whether NPC-1, a new drug, can help people with early memory changes or Alzheimer's. Your blood or PET scan will show if you have Alzheimer's-related brain changes, which is required for this study.
Boston, MassachusettsAges 55 years+ - NCT07392723RecruitingPhase 2
Flaxseed nutrition to protect memory in APOE4 adults
This study tests a special flaxseed-based nutrition drink to see if it can slow memory loss in older adults who have the APOE4 gene and mild cognitive impairment (early memory trouble). If you qualify, you'll take the drink daily for a year and have memory tests and brain scans.
New Brunswick, New JerseyAges 60 years+ - NCT07418008Recruiting
Thinking and memory study for people with liver cirrhosis
This study is creating a new test to measure thinking and memory problems in people with liver cirrhosis. It may help doctors find these problems earlier.
Ambāla, HaryanaAges 18–75 - NCT07416799Recruiting
Home strength training for diabetes and mild memory loss
This study tests whether a home strength-training program using a smartphone app is doable for older adults with type 2 diabetes who also have mild memory problems. You'll do simple exercises at home, and the program may help improve your thinking and glucose control.
Galveston, TexasAges 55–80
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Common questions
- Are there clinical trials for cognitive decline?
- Yes. Clin2 currently lists 181 recruiting cognitive decline studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive decline trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive decline trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.