Clinical trials
Rectal Cancer Stage III clinical trials
Below are recruiting rectal cancer stage iii clinical trials, each written for real people, not researchers. We’re tracking 92 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07735624RecruitingPhase 2
Immunotherapy before surgery for early rectal cancer
This trial tests a combination of two immunotherapy drugs (botensilimab and balstilimab) given before surgery for early-stage rectal cancer that is MSS/pMMR. The goal is to see if this treatment can shrink the tumor and improve outcomes compared to standard care.
Boston, MassachusettsAges 18 years+ - NCT07125729Recruiting
Early cancer detection test for colorectal cancer
This trial uses two blood tests (Signatera and Haystack) to look for tiny bits of cancer DNA after surgery, to find out if the cancer comes back as early as possible. People with stage II, III, or IV colorectal cancer who have had or will have surgery to remove their tumor may join.
Goodyear, ArizonaAges 18 years+ - NCT06824688Recruiting
Comparing robotic surgery types for rectal cancer
This trial compares two robotic surgery methods for rectal cancer: using one small incision (single-port) versus several small incisions (multi-port). The goal is to see which approach offers better outcomes while preserving the sphincter (the muscle that controls bowel movements).
ChongqingAges 18 years+ - NCT07269249Recruiting
Dostarlimab before surgery for advanced rectal cancer
This study looks at how well the immunotherapy drug dostarlimab works before surgery in patients with a specific type of advanced rectal cancer that has DNA repair problems (called dMMR/MSI-H). The goal is to see if it is safe and effective in the real world.
NaplesAges 18 years+ - NCT07143487Recruiting
Family communication after genetic testing for colon cancer
This trial studies how patients with newly diagnosed colon cancer share genetic test results with their family members. It aims to improve communication and support after learning about hereditary risk.
Anchorage, AlaskaAges 18 years+ - NCT06802172Recruiting
Timing meals during cancer treatment for Alaska Native patients
This study tests whether scheduling meals at specific times of day can improve how patients feel during cancer treatment. It is for Alaska Native or American Indian people with certain cancers (rectal, HER2+ or triple negative breast, or other solid tumors) who are receiving neoadjuvant (before surgery) or adjuvant (after surgery) therapy.
Anchorage, AlaskaAges 21 years+ - NCT03594630RecruitingEarly Phase 1
Watchful waiting then chemotherapy before surgery for rectal cancer
This trial studies whether a period of active surveillance (watching closely) and chemotherapy before surgery can improve outcomes for people with stage II–III rectal cancer. You would also receive standard chemo-radiation if you qualify, then proceed to surgery.
Houston, TexasAges 18 years+ - NCT03803553RecruitingPhase 3
Testing blood tumor DNA treatment after stage III colon surgery
This trial studies how to find tiny hidden cancer cells after stage III colon cancer surgery using a blood test. If the blood test shows tumor DNA, you may get additional treatment to lower the chance of cancer coming back.
Boston, MassachusettsAges 18 years+ - NCT04103567Recruiting
Testing stool and bacteria clues for poor rectal cancer response
This study looks at stool samples to see whether gut bacteria or other microbes help explain why some rectal cancers respond less well to treatment given before surgery. If you have mid or lower rectal cancer and are planning pre-surgery treatment, your information and stool sample may help researchers improve how treatment is chosen.
Montpellier, HéraultAges 18 years+ - NCT04288999RecruitingPhase 3
Surgery plus chemo versus chemo-radiation then surgery for recurrent rectal cancer
This study compares two treatment plans for locally recurrent rectal cancer: (1) surgery plus chemo, or (2) chemo plus radiation first, then surgery, followed by chemo. It aims to see which approach works better in controlling the cancer and helping patients recover.
ChibaAges 20–80 - NCT04495088RecruitingPhase 3
Before vs after chemotherapy for locally advanced rectal cancer
This Phase 3 study compares giving chemotherapy before rectal surgery versus giving it after surgery, using a tailored plan based on your risk. The goal is to see which timing helps more people with locally advanced rectal cancer stay cancer-free and live longer.
MannheimAges 18 years+ - NCT04703101RecruitingPhase 1
Short radiation plus chemo for stage II–III rectal cancer
This trial tests a short course of radiation therapy combined with chemotherapy for people with stage II or III rectal cancer. It’s designed to see whether this approach is safe and effective before or around cancer surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT04725903Recruiting
Proton beam radiation for high-risk prostate cancer
This trial tests proton radiation therapy for people with high-risk prostate cancer. It may help by delivering radiation in a more targeted way, with the goal of controlling the cancer while reducing exposure to nearby healthy tissue.
Atlanta, GeorgiaAges 18 years+ - NCT04907643Recruiting
Virtual reality program to reduce stomach-cancer pain
This trial tests whether virtual reality (VR) can improve pain and other day-to-day symptoms in people with certain gastrointestinal cancers. You’d use VR for pain relief while researchers measure how you’re feeling.
Los Angeles, CaliforniaAges 18–99 - NCT05081024Recruiting
Blood test biomarker to help preserve organs in rectal cancer
This study looks at a blood test (ctDNA, a way to detect cancer DNA in the bloodstream) to help doctors choose treatment that may spare organs for people with stage II–III rectal cancer. You may be followed to see how well the blood test can guide treatment decisions.
Portland, OregonAges 18 years+ - NCT05148767RecruitingPhase 4
UGT1A1-guided irinotecan for locally advanced rectal cancer
This trial studies whether adjusting irinotecan treatment based on a person’s UGT1A1 gene test can improve outcomes for locally advanced rectal cancer. It focuses on people who are about to start (or continue) chemoradiation and do not have cancer spread to distant organs.
Hangzhou, ZhejiangAges 18–75 - NCT05179889RecruitingPhase 2/Phase 3
Chemo after surgery for high-risk stage III colon cancer
This trial tests giving mFOLFIRINOX chemotherapy after curative surgery for people with high-risk stage III colon cancer. It aims to lower the chance that cancer comes back.
DaejeonAges 20–75 - NCT05576480RecruitingPhase 2
Immunotherapy plus chemotherapy before surgery for rectal cancer without mismatch repair
This Phase 2 study tests penpulimab (an immunotherapy medicine) given with CAPEOX chemotherapy before surgery for rectal cancer that is “MSS” (not the mismatch-repair type). It aims to shrink the tumor and improve outcomes by treating before the operation.
Shanghai, None SelectedAges 18–75 - NCT05870800RecruitingPhase 2
Study Immunotherapy and Chemotherapy Before Colon Surgery
This trial tests immunotherapy plus chemotherapy given before surgery for colon cancer that hasn’t spread. It aims to shrink or control the tumor and improve outcomes in people whose tumor has certain immune/biologic features.
Houston, TexasAges 18–80 - NCT05914766Recruiting
Support program for newly diagnosed rectal cancer patients
This trial tests an informational and supportive care program for people with newly diagnosed, locally advanced rectal cancer. It may help by providing education and practical support around next steps in treatment.
Boston, MassachusettsAges 18 years+ - NCT05946213RecruitingPhase 3
Shorter radiation treatment for high-risk prostate cancer
This trial tests whether a shorter course of radiation works as well as the usual longer course for people with high-risk prostate cancer. The goal is to keep cancer control while possibly reducing treatment time and inconvenience.
Birmingham, AlabamaAges 18 years+ - NCT05957016RecruitingPhase 2
New treatment before and during rectal radiation with chemo
This Phase 2 study tests a treatment plan given before surgery (neoadjuvant) along with radiation and chemotherapy (concurrent chemoradiotherapy) for locally advanced rectal cancer. It may help shrink the cancer before the next steps of care and improve control of the disease.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT06006390RecruitingPhase 1/Phase 2
CAR-T therapy for CEA-positive advanced solid tumors
This trial tests a new treatment called CAR-T cells that are designed to find and attack cancer cells carrying a protein called CEA. It is for people with advanced colorectal, esophageal, stomach, or pancreatic cancer who have already tried other treatments.
Taiyuan, ShanxiAges 18 years+ - NCT06076811Recruiting
Guiding colorectal cancer follow-up with a blood test
This trial uses a blood test (liquid biopsy) to look for tiny bits of cancer DNA remaining after surgery. It aims to see if this test can help guide follow-up and treatment decisions for people with colorectal cancer.
Copenhagen, Capital Region of DenmarkAges 18 years+
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Common questions
- Are there clinical trials for rectal cancer stage iii?
- Yes. Clin2 currently lists 92 recruiting rectal cancer stage iii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rectal cancer stage iii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rectal cancer stage iii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.