Clinical trials
Colorectal Cancer (Diagnosis) clinical trials
Below are recruiting colorectal cancer (diagnosis) clinical trials, each written for real people, not researchers. We’re tracking 349 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05967143Recruiting
Registry study for first-time SIR-Spheres in liver tumors
This is an observational (real-world) study that follows people with certain unresectable liver tumors who are getting SIR-Spheres for the first time. It helps doctors understand how this treatment is used in routine care and what outcomes patients experience.
Clichy, CedexAges 18 years+ - NCT06321081RecruitingPhase 2
Rechallenge combo for metastatic colorectal cancer
This trial tests a combination of three drugs (cetuximab, irinotecan, and envafolimab) as a ‘rechallenge’ – meaning if you had good results with cetuximab or irinotecan before, trying them again with a new drug might help shrink or control your cancer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06910670Recruiting
Web tool for cancer treatment decisions
This trial tests a web-based tool to help people with certain cancers make treatment decisions. It is for patients already enrolled in a related study at Washington University.
St Louis, MissouriAges 18 years+ - NCT03947385RecruitingPhase 1/Phase 2
First drug test for metastatic uveal melanoma with specific gene changes
This Phase 1/2 trial studies IDE196 in adults with metastatic uveal melanoma that has certain gene mutations or fusions. It’s mainly testing safety and correct dosing, and may help shrink tumors in patients matched to the tumor’s genetic changes.
Los Angeles, CaliforniaAges 18 years+ - NCT04120935Recruiting
Observational study for adults with possible or confirmed bowel cancer
This study mainly watches and records health information from adults with colorectal cancer (or a strong suspicion of it). It collects past tumor tissue and other clinical details to better understand the disease and care.
Biella, BiellaAges 18 years+ - NCT04622423Recruiting
Advanced therapies for colon or pancreas liver metastases
This study tests advanced treatments for cancer that has spread to the liver, either from colon cancer or pancreatic cancer. It may help by targeting liver tumors using treatment plans and, for some participants, liver tissue samples.
Milan, MilanAges 18 years+ - NCT04792684Recruiting
Collecting colon samples from adults with colon findings
This study collects body samples to help evaluate tests for people with suspected or newly diagnosed colorectal conditions, often around the time of colonoscopy or surgery. Depending on the arm, you may be asked to have a colonoscopy soon or to provide samples before planned surgery.
Chula Vista, CaliforniaAges 45–84 - NCT05197322RecruitingPhase 2
Pembrolizumab before surgery for MMR-deficient colon or rectal cancer
This trial tests pembrolizumab (an immunotherapy medicine) given before curative surgery in people with certain MMR-deficient colon or rectal cancers. It aims to shrink or control the cancer so surgery can be done more effectively, and to see if outcomes improve compared with standard care.
CambridgeAges 18 years+ - NCT05319314RecruitingPhase 1/Phase 2
Study drug for advanced colon cancer that has come back or failed
This Phase 1/2 trial tests LYL273, a new targeted treatment, for people with metastatic colorectal (colon) cancer that has returned or not responded to standard chemo. It’s designed to see how well the drug can control the cancer and what side effects it causes.
Duarte, CaliforniaAges 18 years+ - NCT05355363Recruiting
Check what happens after missed colon follow-up for colon polyps
This study looks at the risk of new or advanced colon findings in people who had certain colon polyp results, but then did not get the recommended follow-up colonoscopy on time. It may help doctors fine-tune how urgently different patients need repeat colon checks.
Montreal, QuebecAges 45–80 - NCT05768503RecruitingPhase 3
Test new drugs after colorectal cancer chemotherapy
This Phase 3 trial compares a new treatment combination (chidamide plus sintilimab plus bevacizumab) versus the standard second-line chemotherapy (FOLFIRI plus bevacizumab) for advanced colorectal cancer that is microsatellite stable/low. It aims to see which treatment works better and is safer for people whose cancer grew after first-line oxaliplatin-based therapy.
Hefei, AnhuiAges 18–75 - NCT05913674RecruitingPhase 2
Feasibility of modified chemotherapy after bowel surgery
This Phase 2 study tests whether a modified chemotherapy given inside the abdomen soon after surgery is practical and safe. It may help people with appendix or colon cancer that has spread within the abdomen (peritoneal carcinomatosis) by targeting cancer cells after tumor removal.
Montreal, QuebecAges 18 years+ - NCT05994482Recruiting
Surveillance colonoscopy study in older veterans
This study looks at how often older veterans (age 75 and older) should get a follow-up colonoscopy after having polyps removed. Researchers will review medical records and talk to patients and doctors to help create better guidelines for surveillance colonoscopies in older adults.
San Diego, CaliforniaAges 75 years+ - NCT06059963Recruiting
Simple blood test for colorectal cancer screening
This study is testing a new blood test (Signal-C) to see if it can help find colorectal cancer early. You may be able to join if you are average risk and getting a routine screening colonoscopy.
Raonoke, VirginiaAges 45–84 - NCT06168786RecruitingPhase 2
New drug combo and radiation for advanced colorectal cancer
This trial tests a new combination of drugs (cadonilimab, fruquintinib) plus targeted radiation (SBRT) for people with advanced MSS colorectal cancer who have already tried several standard treatments. The goal is to see if this combination can help shrink tumors or slow disease progression.
Wuhan, HubeiAges 18–75 - NCT06280495RecruitingPhase 2/Phase 3
Targeted drugs plus chemo before surgery for colon cancer with liver spread
This trial tests whether adding two targeted drugs (serplulimab and bevacizumab) to standard chemotherapy before surgery can improve outcomes for people with colorectal cancer that has spread to the liver. It is for those whose cancer has certain genetic features and is considered resectable.
Guangzhou, GuangdongAges 18–75 - NCT05785780Enrolling by invitation
Help improve colon cancer screening for people with diabetes
This study looks for better ways to make sure people with diabetes get up-to-date colon cancer screening. If you haven’t had the recommended test on time, it may help identify barriers in primary care and improve screening follow-through.
New Brunswick, New JerseyAges 50–74 - NCT06402188Recruiting
ColoSeal Device Study for Rectal Cancer Surgery
This study tests a new device called the ColoSeal ICD System that may help protect the reconnection of your bowel after surgery for rectosigmoid or rectal cancer. It is designed for people who are already scheduled for surgery that includes a temporary colostomy or ileostomy.
YerevanAges 18–70 - NCT06515821Recruiting
Improving colorectal cancer screening and diagnosis
This study collects data to improve how colorectal cancer is found and diagnosed. It compares new testing methods (like breath and stool tests) with standard colonoscopy in people with and without cancer or risk factors.
SofiaAges 18 years+ - NCT06516445RecruitingPhase 2
Short radiation plus targeted drugs before surgery for rectal cancer
This trial tests a new combination of treatments before surgery for locally advanced rectal cancer. You would receive short-course radiation, then an immunotherapy drug (camrelizumab) plus a PARP inhibitor (fluzoparib) and chemotherapy, to shrink the tumor and make surgery more successful.
Wuhan, HubeiAges 18–75 - NCT06551207Recruiting
New drug combo with radiation for advanced MSS colon cancer
This trial tests a new combination—an immunotherapy drug (cadonilimab) plus a targeted anti-angiogenesis pill (fruquintinib) and focused radiation (SBRT)—for people with MSS colorectal cancer that has progressed after at least two prior treatments. The goal is to see if this triple approach can help shrink or control the cancer better than standard options.
Wuhan, HubeiAges 18–75 - NCT06558773RecruitingPhase 2
New drug combo for previously treated colorectal cancer
This trial tests a combination of a GSL synthesis inhibitor, an immunotherapy drug, and/or regorafenib in people with a specific type of colorectal cancer (pMMR/MSS) that has not responded to at least two prior treatments. The goal is to see if this new approach can help shrink or control the cancer.
Beijing, Biotherapeutic Department of Chinsese PLA Gereral HospitalAges 18–75 - NCT06720987RecruitingPhase 1
KQB365 for advanced solid tumors with KRAS mutations
This trial tests a new drug called KQB365, alone or with other drugs, for people with advanced solid tumors that have a specific KRAS mutation (G12C or G12S). It aims to see if the treatment is safe and effective.
Phoenix, ArizonaAges 18 years+ - NCT06808685Recruiting
Study of Elovie for advanced colorectal cancer
This study looks at how well a biosimilar version of bevacizumab (Elovie) works in people with advanced colorectal cancer that has spread and cannot be surgically removed. It aims to see if Elovie is safe and effective when used as the first treatment for this cancer.
Vitória, Espírito SantoAges 18 years+
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Common questions
- Are there clinical trials for colorectal cancer (diagnosis)?
- Yes. Clin2 currently lists 349 recruiting colorectal cancer (diagnosis) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer (diagnosis) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer (diagnosis) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.