Clinical trials
Colorectal Cancer (Locally Advanced or Metastatic) clinical trials
Below are recruiting colorectal cancer (locally advanced or metastatic) clinical trials, each written for real people, not researchers. We’re tracking 5,580 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05874492Recruiting
Spa therapy for radiation-related skin fibrosis after cancer
This trial tests whether a spa therapy program can improve “fibrosis,” or stiffened/scarred tissue and related skin problems, after radiotherapy for breast cancer or upper head/neck cancers. It aims to see if treatment can improve quality of life for people who still have moderate-to-worse symptoms months after radiation.
BordeauxAges 18 years+ - NCT05946824RecruitingPhase 2
Radiation for prostate cancer that returned after surgery
This trial tests a new way of delivering radiation for prostate cancer that has come back after prostate surgery. It may help control the cancer by targeting the “prostate bed” area or nearby lymph nodes where it returned.
Rochester, New YorkAges 18 years+ - NCT06205316RecruitingPhase 3
Radiation therapy for returning or limited-spread prostate cancer
This trial compares two types of radiation therapy for prostate cancer that has come back or spread to a few places after surgery. The goal is to see which radiation schedule works better with fewer side effects.
Scottsdale, ArizonaAges 18 years+ - NCT06208657RecruitingPhase 1/Phase 2
Personalized cancer therapy for kids and teens
This trial tests personalized cancer treatments for children and teens whose cancer has not responded to standard therapy. It uses information from precision medicine studies to match the right drug to each child's tumor.
Newcastle, New South WalesAges birth–21 years - NCT06264167Recruiting
Ultrasound for groin lymph nodes in vulvar cancer
This trial tests whether using ultrasound of the groin can help find cancer spread in the lymph nodes of women with early-stage vulvar cancer. The goal is to see if ultrasound can replace or reduce the need for more invasive surgery.
Brisbane, QueenslandAges 18 years+ - NCT06276868RecruitingPhase 2
Darsilide plus hormone therapy and double antibody for breast cancer
This trial tests if adding a new drug (darsilide) to standard hormone therapy and two antibodies (trastuzumab and pertuzumab) before surgery can improve outcomes for women with HR-positive, HER2-positive breast cancer that hasn't spread.
Henan, HenanAges 18–70 - NCT06330805RecruitingPhase 2
Comparing heart effects of two hormone therapies for prostate cancer
This trial compares two hormone therapies, relugolix and leuprolide, to see which one is better for your heart health in men with prostate cancer. It's for men with a specific type of prostate cancer that is not yet advanced.
Columbus, OhioAges 18 years+ - NCT06443866Recruiting
I-124 PET/CT Imaging for Thyroid Cancer
This study uses a special type of PET/CT scan (I-124) to see where thyroid cancer is in your body and how much radiation it would get from radioactive iodine therapy. It helps doctors plan treatment for people whose cancer may not respond to standard radioactive iodine or who are being considered for targeted medicines.
North Miami, FloridaAges 18 years+ - NCT06532006RecruitingPhase 3
HLX22 plus trastuzumab and chemo for HER2+ stomach cancer
This trial tests adding a new drug, HLX22, to the standard combination of trastuzumab and chemotherapy for people with HER2-positive stomach or gastroesophageal junction cancer that hasn't been treated yet. The goal is to see if this three-drug mix works better than the usual two-drug approach.
Anaheim, CaliforniaAges 18 years+ - NCT06558786Recruiting
Registry for esophageal cancer that has spread to a few spots
This study tracks patients with stage IV esophageal or gastroesophageal junction cancer that has spread to only a limited number of places (like the liver, lung, or a few lymph nodes). The goal is to understand how well treatments like surgery or radiation work after initial drug therapy.
New York, New YorkAges 18 years+ - NCT06589388Recruiting
Using a blood test to predict rectal cancer treatment success
This trial is looking at whether a simple blood test (ctDNA monitoring) can help predict how well total neoadjuvant therapy (chemo and radiation before surgery) works for rectal cancer. It may help doctors tailor treatment to your specific needs.
Ho Chi Minh CityAges 18–80 - NCT07690917Recruiting
New PET scanner study for people with cancer
This trial tests a new PET scanner that may help doctors see where cancer is in your body more clearly. It is for adults with lung, prostate, or head and neck cancer who are already scheduled for a PET-CT scan at Memorial Sloan Kettering.
Basking Ridge, New JerseyAges 18 years+ - NCT06668454Recruiting
Chemoimmunotherapy before surgery for limited spread esophageal cancer
This trial tests a treatment plan that combines chemotherapy with immunotherapy, followed by surgery, for people whose esophageal or stomach cancer has spread to a few areas (oligometastatic). The goal is to see if this approach can shrink the cancer and improve outcomes.
Toronto, OntarioAges 18–80 - NCT06672497Recruiting
Testing a light sensor for muscle health in breast and gynecological cancer patients
This study uses a safe, non-invasive light sensor (near-infrared spectroscopy) to measure how well your muscles use oxygen. Researchers want to learn if this tool can help monitor muscle health in people with breast or gynecological cancer that has not spread to other parts of the body.
Greenville, South CarolinaAges 20 years+ - NCT06690775RecruitingPhase 2
Study of a new drug for platinum-resistant ovarian cancer
This trial tests an investigational drug called TORL-1-23 for people with ovarian cancer that has stopped responding to platinum chemotherapy. It aims to see if the drug can help shrink or control the cancer.
Phoenix, ArizonaAges 18 years+ - NCT06728579RecruitingPhase 2
Group therapy for joint pain in breast cancer survivors
This study tests two supportive group programs—one using mindfulness skills, the other providing supportive talk therapy—to help breast cancer survivors manage joint pain caused by hormone-blocking pills. If you have ongoing joint pain and are taking an aromatase inhibitor, you may be able to join a free, video-based group.
San Diego, CaliforniaAges 18 years+ - NCT06856603RecruitingPhase 2
Radiation therapy for people with 6 to 10 metastases
This trial tests a special type of radiation (Stereotactic Ablative Radiation Therapy) for people who have 6 to 10 metastases from a cancer that is growing or has not fully responded to treatment. It may be an option if surgery isn't possible for all the spots and you haven't had radiation to them before.
Obninsk, Kaluga OblastAges 18 years+ - NCT06858813RecruitingPhase 1
ABBV-324 for advanced liver or lung cancer
This study tests an experimental IV drug (ABBV-324) for adults with advanced liver cancer (HCC) or advanced squamous lung cancer (LUSC). It aims to see if the drug is safe and whether it can help control the disease.
Duarte, CaliforniaAges 18 years+ - NCT06906341RecruitingPhase 2
Relacorilant combo for gynecologic cancers
This trial tests a drug called relacorilant combined with different treatments for ovarian, fallopian tube, primary peritoneal, or endometrial cancers. It may help patients whose cancer has stopped responding to standard therapies.
Birmingham, AlabamaAges 18 years+ - NCT06906887RecruitingPhase 2
Pulsed low-dose radiation vs standard chemoradiation for esophageal cancer
This trial compares a new way of giving radiation (in short, pulsed low-dose bursts) to the standard method, both combined with chemotherapy, for people with esophageal cancer. It aims to see if the pulsed approach is safer and equally effective.
Milwaukee, WisconsinAges 18 years+ - NCT06965192Recruiting
Visual tools for cancer surgeon decision-making
This trial tests visual tools to help surgeons make better decisions for patients with early-stage prostate or kidney cancer. It may help you and your doctor choose the best treatment.
Chapel Hill, North CarolinaAges 18 years+ - NCT06967103RecruitingPhase 2
New drug before breast cancer surgery
This trial tests a new drug, QL1706, given alongside chemotherapy before surgery for a certain type of breast cancer. It aims to see if this combination helps shrink tumors before they are removed.
ZhengzhouAges 18 years+ - NCT06994195RecruitingPhase 3
Comparing an experimental drug to standard chemo for ovarian cancer
This trial tests a new drug called BL-B01D1 against standard chemotherapy for people with ovarian cancer that no longer responds to platinum-based treatments. The goal is to see which option works better.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07015944Recruiting
Moving on after breast cancer: a depression trial for survivors in Pakistan
This study tests a program called "Moving on After Breast Cancer" for women in Pakistan who have finished breast cancer treatment and now have depression. The goal is to see if this program helps them feel better emotionally.
Karachi, SindhAges 18 years+
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Common questions
- Are there clinical trials for colorectal cancer (locally advanced or metastatic)?
- Yes. Clin2 currently lists 5,580 recruiting colorectal cancer (locally advanced or metastatic) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer (locally advanced or metastatic) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer (locally advanced or metastatic) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Breast Cancer
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Locally Advanced Colorectal Cancer
- Lung Cancer (Locally Advanced or Metastatic)
- Liver Cancer (Locally Advanced or Metastatic)
- Metastatic Colorectal Cancer
- Locally Advanced Rectal Cancer
- Metastatic Colorectal Cancer (CRC)
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.