Clinical trials
Colorectal Cancer (Locally Advanced or Metastatic) clinical trials
Below are recruiting colorectal cancer (locally advanced or metastatic) clinical trials, each written for real people, not researchers. We’re tracking 5,490 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06139627Recruiting
Geriatric assessment for older adults with lung cancer getting chemotherapy and radiation
This trial tests whether a special geriatric assessment can help manage side effects for adults aged 60 and older with non-small cell lung cancer who are starting a new treatment plan that includes chemotherapy and radiation. It aims to improve quality of life and treatment outcomes.
Duarte, CaliforniaAges 60 years+ - NCT06129747RecruitingPhase 2
Repeat Lumpectomy and Daily Partial Breast Radiation for Cancer Return
This trial studies a second breast-conserving surgery followed by daily radiation to just the tumor area for people whose breast cancer has returned in the same breast. It aims to see if this approach is safe and effective, potentially avoiding a mastectomy.
Cleveland, OhioAges 19 years+ - NCT06137274RecruitingPhase 2
Adaptive radiation boost for head and neck cancer
This trial tests a new way of giving radiation therapy, called adaptive radiation boost, for people with head and neck cancer. The goal is to see if this approach can better target the cancer and possibly improve outcomes.
Tampa, FloridaAges 18 years+ - NCT06118086RecruitingPhase 1/Phase 2
Study of REM-422 for advanced adenoid cystic carcinoma
This trial tests an experimental drug called REM-422 for people with adenoid cystic carcinoma (ACC) that has spread, come back, or cannot be removed by surgery. The study has two parts: an early part for people with advanced ACC and a later part for those with a specific genetic change (MYB biomarker) in their tumor. The goal is to see if REM-422 can slow or stop cancer growth.
San Francisco, CaliforniaAges 18 years+ - NCT06112314RecruitingPhase 3
New immunotherapy combo for advanced melanoma (first treatment)
This trial tests a new immunotherapy drug (IMC-F106C) combined with standard treatments against the usual nivolumab-based therapy for people with advanced melanoma who have not been treated before. It's for people who carry a specific immune system marker (HLA-A*02:01) and are in fairly good health.
Tucson, ArizonaAges 18 years+ - NCT06122896RecruitingEarly Phase 1
Screening for pancreatic cancer in high-risk people
This trial uses MRI and endoscopic ultrasound to look for early signs of pancreatic cancer in people who have a high risk due to their genes or family history. Finding it early may lead to better treatment options.
Boston, MassachusettsAges 18 years+ - NCT06107673RecruitingPhase 2
Pill vs chemo before breast cancer surgery
This study compares taking a daily pill (dalpiciclib with hormone therapy) versus standard chemotherapy before breast cancer surgery. It's for postmenopausal women with a common type of early breast cancer that is strongly hormone-receptor positive and HER2-negative.
Shijiazhuang, HebeiAges 18–75 - NCT06107920RecruitingPhase 3
Chemotherapy before surgery for blocked colon cancer
This trial tests whether giving chemotherapy before surgery helps people with colon cancer that caused a blockage and needed a temporary colostomy. It aims to improve outcomes compared to standard treatment.
AmiensAges 18 years+ - NCT06105801RecruitingPhase 4
Comparing two biopsy methods for lung cancer genetic testing
This study compares two ways to get a larger tissue sample from lymph nodes in the chest after a first small test confirmed cancer. The goal is to see which method provides better material for detailed genetic testing (next generation sequencing) that can guide treatment choices.
Nashville, TennesseeAges 18 years+ - NCT06099119RecruitingPhase 4
PERT for pancreatic enzyme insufficiency in pancreatic cancer
This trial tests if a pancreatic enzyme replacement therapy (PERT) helps weight loss caused by tumors in the head of the pancreas. It may improve nutrition for people with advanced pancreatic cancer.
MilanAges 18 years+ - NCT06085742RecruitingPhase 2
CMC chemotherapy for early stage breast cancer
This trial tests a chemotherapy combination (CMC) for people with early-stage, hormone receptor-positive, HER2-negative breast cancer who have a high risk of recurrence. It aims to understand if this oral regimen is effective and tolerable.
Chicago, IllinoisAges 18 years+ - NCT00291096Recruiting
Clinic program for women at high risk of breast cancer
This trial enrolls women who are at higher-than-usual risk of developing breast cancer to help guide prevention and monitoring. You may be asked to get a recent mammogram, have blood tests, and follow medication/supplement changes.
Kansas City, KansasAges 30–65 - NCT05244239RecruitingPhase 1
Radiation plus lurbinectedin for advanced small cell lung cancer
This trial studies whether adding palliative (comfort-focused) radiation to the medicine lurbinectedin can better control extensive-stage small cell lung cancer. It may help reduce problems from tumors in places like bones and organs.
Atlanta, GeorgiaAges 18 years+ - NCT05754580Recruiting
Boost radiation for intermediate or higher-risk prostate cancer
This study tests a stronger, focused radiation plan for intermediate to higher-risk prostate cancer. It combines a high-dose internal radiation “boost” with external radiation to try to improve cancer control while keeping side effects manageable.
Omaha, NebraskaAges 19 years+ - NCT03750981Recruiting
Physical activity program for adults after or during cancer care
This trial tests whether a supervised physical activity program (CrossFit-style workouts) is safe and helpful for adults with cancer. It may help improve strength and well-being, but your doctor must clear you to participate.
Detroit, MichiganAges 18 years+ - NCT06072781RecruitingPhase 3
Study of Avutometinib + Defactinib for recurrent low-grade ovarian cancer
This trial tests a combination of two oral targeted drugs for people with recurrent low-grade serous ovarian cancer. It aims to see if this therapy works better than standard hormone therapy or chemotherapy options.
Phoenix, ArizonaAges 18 years+ - NCT06064877RecruitingPhase 3
Study of ficlatuzumab plus cetuximab for advanced head and neck cancer
This trial tests a combination of two drugs, ficlatuzumab and cetuximab, for people with recurrent or metastatic head and neck cancer that is HPV-negative and has not responded to prior immunotherapy and chemotherapy. It aims to see if this combination can help shrink tumors or slow the disease.
Gilbert, ArizonaAges 18 years+ - NCT06073184RecruitingPhase 2
Weight-loss drug for fertility-sparing treatment of early uterine cancer
This study tests a weight-loss medication called semaglutide (Wegovy) combined with a hormonal intrauterine device (Mirena) for treating early-stage uterine cancer or precancerous changes in the uterus, while preserving fertility. The goal is to see if this combination can shrink or eliminate the abnormal cells, allowing patients to keep the option of having children.
Toronto, OntarioAges 18–41 - NCT06066437RecruitingPhase 1/Phase 2
Lutetium before prostate surgery for high-risk cancer
This trial tests a radioactive drug (lutetium) given before surgery to men with high-risk prostate cancer that hasn't spread. The goal is to see if it can shrink the tumor and improve outcomes.
Houston, TexasAges 18 years+ - NCT04656041RecruitingPhase 2
Test chemo with radiation for gastroesophageal cancer
This Phase 2 study tests a combination of chemotherapy (5-FU/leucovorin plus irinotecan and oxaliplatin) together with radiation for certain types of esophagus/stomach-junction cancer. It may help shrink tumors and control cancer that is locally advanced but not spread to distant organs.
Boston, MassachusettsAges 18 years+ - NCT06038578RecruitingPhase 2
TRK-950 with standard chemo for advanced stomach cancer
This trial tests a new drug, TRK-950, added to standard chemotherapy (ramucirumab and paclitaxel) for people with advanced stomach or gastroesophageal junction cancer that has worsened after previous treatment. The goal is to see if this combination can help shrink tumors or slow disease progression.
Duarte, CaliforniaAges 18 years+ - NCT06038227Recruiting
Robotic vs. VATS surgery for early lung cancer
This study compares two types of minimally invasive surgery—robotic-assisted (da Vinci) and VATS—for people with early-stage non-small cell lung cancer. The goal is to see which approach might work better and help patients recover faster.
CopenhagenAges 18 years+ - NCT06050733Recruiting
Gut bacteria and immunotherapy response in solid tumors
This study looks at how the bacteria in your gut may affect how well immunotherapy works for solid cancers that have spread or cannot be removed. It focuses on people who have been on certain immunotherapy drugs (PD-1 or PD-L1 inhibitors) for at least 3 months but less than 2 years.
Galveston, TexasAges 35–75 - NCT06037980RecruitingPhase 2/Phase 3
Chemotherapy before surgery for high-risk bile duct cancer
This trial tests whether receiving chemotherapy (cisplatin, gemcitabine, and nab-paclitaxel) before surgery can improve outcomes for people with high-risk bile duct or gallbladder cancer. It compares this approach to going straight to surgery.
AnconaAges 18–75
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Common questions
- Are there clinical trials for colorectal cancer (locally advanced or metastatic)?
- Yes. Clin2 currently lists 5,490 recruiting colorectal cancer (locally advanced or metastatic) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer (locally advanced or metastatic) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer (locally advanced or metastatic) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Breast Cancer
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Locally Advanced Colorectal Cancer
- Lung Cancer (Locally Advanced or Metastatic)
- Liver Cancer (Locally Advanced or Metastatic)
- Metastatic Colorectal Cancer
- Locally Advanced Rectal Cancer
- Metastatic Colorectal Cancer (CRC)
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.