Clinical trials
Colorectal Cancer Prevention clinical trials
Below are recruiting colorectal cancer prevention clinical trials, each written for real people, not researchers. We’re tracking 103 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06696768RecruitingPhase 1
New drug plus standard chemotherapy for advanced colorectal cancer
This trial combines a new experimental drug (emavusertib) with standard chemotherapy (FOLFOX plus bevacizumab) for people with stage IV colorectal cancer who have not yet received chemotherapy. The goal is to see if the combination is safe and effective, potentially offering a new first-line treatment option.
Gainesville, FloridaAges 18 years+ - NCT06335420Recruiting
Can carrot juice prevent colon polyps from coming back?
This study tests whether drinking carrot juice every day can lower the chance that large colon polyps or early colon cancers will come back. Researchers want to see if the nutrients in carrot juice help protect the lining of the colon.
OdenseAges 18 years+ - NCT07044921RecruitingPhase 2
Irinotecan liposome combination for advanced colorectal cancer
This trial tests a new combination treatment for people with advanced colorectal cancer whose cancer has stopped responding to irinotecan. The goal is to see if adding a liposome form of irinotecan to other drugs can help shrink tumors or slow the disease.
BeijingAges 18 years+ - NCT07393906Recruiting
Eat right, screen right for colorectal cancer prevention
This study looks at how healthy eating and regular screening can help prevent colorectal cancer. You may join if you are an adult who can use a computer or mobile device.
Gainesville, FloridaAges 18 years+ - NCT06411691RecruitingPhase 1
Vaccine plus immunotherapy for KRAS-mutant cancers
This trial tests a cancer vaccine designed to target KRAS-mutated tumors, combined with two immunotherapy drugs, for people with advanced colorectal or pancreatic cancer. It may help the immune system recognize and attack cancer cells.
Baltimore, MarylandAges 18 years+ - NCT07106359Recruiting
Learning about Lynch syndrome genetic services for families
This study tests a program to help families talk about genetic services for Lynch syndrome. It aims to support people who may be at risk but haven't yet had genetic counseling or testing.
Birmingham, AlabamaAges 18 years+ - NCT04185779Recruiting
Colorectal cancer screening colonoscopy study
This study looks at patterns of colorectal (colon and rectum) findings in people who are having a colonoscopy as part of routine care. It may help improve how doctors detect and understand colorectal cancer and related growths over time.
South Shields, Tyne and WearAges 18 years+ - NCT04329494RecruitingPhase 1
Study of targeted drug delivery into the abdomen using PIPAC
This Phase 1 trial tests PIPAC, a way to deliver anti-cancer medicine directly into the abdomen using a minimally invasive procedure. It is for people with peritoneal spread from certain cancers to see whether this approach is safe and potentially helpful.
Duarte, CaliforniaAges 18 years+ - NCT05571644RecruitingPhase 2
Study compares two pre-surgery treatments for locally advanced rectal cancer
This Phase 2 trial tests whether a newer combination chemotherapy plus an immunotherapy medicine (cadonilimab/AK104) works better than standard chemotherapy before surgery for locally advanced colorectal cancer. The goal is to shrink the tumor and improve how well treatment works after surgery.
Guangzhou, GuangdongAges 18–70 - NCT05630794RecruitingPhase 1
Test ONC201 to prevent colorectal polyp return in high-risk people
This Phase 1 study tests whether ONC201 is safe and may help prevent colorectal polyps (adenomas) from coming back. You’d also undergo planned colon/rectum camera exams to check for new or changing polyps.
Ann Arbor, MichiganAges 18 years+ - NCT05850130Recruiting
Acupuncture to treat nerve pain from oxaliplatin chemotherapy
This study tests whether acupuncture can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. It may help lessen symptoms like tingling, numbness, or burning that affect hands or feet.
CréteilAges 18 years+ - NCT06191120Recruiting
FAPI PET scan for aggressive colorectal cancer liver metastases
This trial uses a special PET scan (FAPI) to detect a specific, more aggressive type of colorectal cancer (CMS4) in people who have liver tumors that can be surgically removed. The goal is to see if the scan can help doctors choose the best treatment for you.
Utrecht, UtrechtAges 18 years+ - NCT06202183Recruiting
Home exercise for gut health in young colorectal cancer patients
This study tests whether a home-based exercise program can improve the health of your gut bacteria during chemotherapy for young-onset colorectal cancer. It aims to help you feel better and potentially improve how well your treatment works.
Boston, MassachusettsAges 18–50 - NCT06207656RecruitingPhase 2
Targeted therapy for BRAF V600E mutated colorectal cancer
This trial tests if combining three targeted drugs (cetuximab, encorafenib, and binimetinib) before surgery can shrink or control cancer in people with a specific BRAF V600E mutation and a stable (MSS) tumor. It focuses on colorectal cancer that is either already able to be removed or could become removable with treatment.
MadridAges 18 years+ - NCT06251297Recruiting
Reflexology to prevent nerve damage from chemotherapy
This study tests if foot reflexology can help prevent nerve damage caused by a chemotherapy drug called oxaliplatin in people with colorectal cancer. If it works, it could reduce pain, tingling, or numbness in the hands and feet.
Toulouse, CHU de ToulouseAges 18 years+ - NCT06259149Recruiting
Timing of blood clot prevention after colorectal cancer surgery
This study looks at when to start blood thinners after surgery for colorectal cancer. The goal is to find the safest time to prevent blood clots without increasing bleeding risk.
Shanghai, Shanghai MunicipalityAges 18–110 - NCT06349590RecruitingPhase 1/Phase 2
Diet before colon cancer surgery to reduce recurrence
This trial tests whether a specific diet before colon cancer surgery can change the bacteria in your gut to help prevent the cancer from coming back or spreading. Patients who are eligible will follow the diet for a short time before their operation.
Chicago, IllinoisAges 18 years+ - NCT06371768Recruiting
Helping Young Cancer Survivors Manage Symptoms & Transition to Care
This study is designed to help adolescent and young adult cancer survivors manage symptoms and smoothly transition to post-treatment care. If you finished treatment for certain cancers within the past 1 to 5 years, you may be able to join.
Durham, North CarolinaAges 18–39 - NCT06543836RecruitingPhase 2
Targeted therapy plus immunotherapy for advanced colorectal cancer
This trial tests a combination of a targeted therapy pill (TKI) and an immunotherapy (PD-1 inhibitor) for people with advanced colorectal cancer that has stopped responding to standard treatments. It uses a blood test to tailor the treatment, aiming to be more effective with fewer side effects.
Beijing, Beijing MunicipalityAges 18–80 - NCT06629051Recruiting
Long-term follow-up after berberine treatment trial
This study checks on people who took berberine in an earlier trial to see how they are doing 6 years later. It helps researchers understand the long-term effects of the treatment.
ShanghaiAges Any age - NCT06776757RecruitingPhase 1/Phase 2
Sintilimab plus cetuximab and chemo for first-line advanced colorectal cancer
This trial tests a combination of immunotherapy (sintilimab), a targeted therapy (cetuximab), and chemotherapy as a first treatment for advanced colorectal cancer that hasn't spread or come back after earlier treatment. It's for people whose tumors have certain genetic markers (RAS/BRAF wild-type) and show signs of immune activity (PD-L1 or CD8+ TILs).
Shenzhen, GuangdongAges 18–75 - NCT06799793Recruiting
AI screening for early colorectal cancer detection
This study uses an artificial intelligence model to analyze test results from the fecal immunochemical test (FIT) to help find colon cancer early. You may benefit if you are 50-69 and had a positive FIT result as part of a screening program.
Bologna, BolognaAges 50–69 - NCT06827366Recruiting
Lifestyle study for people at high risk of colorectal cancer
This study tests a lifestyle program for people who are at high risk for colorectal cancer but have not been diagnosed. The goal is to see if healthy changes can help lower your risk over one year.
Lyon, FranceAges 35–74 - NCT06864338Recruiting
Pilot study for a new colorectal cancer screening test
This study tests a new stool-based test for detecting colorectal cancer and advanced polyps. It aims to see how well it works compared to a colonoscopy. The results may lead to a simpler screening option.
Morrisville, North CarolinaAges 18 years+
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Common questions
- Are there clinical trials for colorectal cancer prevention?
- Yes. Clin2 currently lists 103 recruiting colorectal cancer prevention studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer prevention trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer prevention trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.