Clinical trials
Colorectal Cancer Screening clinical trials
Below are recruiting colorectal cancer screening clinical trials, each written for real people, not researchers. We’re tracking 379 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07559825Recruiting
Understanding Early-Onset Colorectal Cancer in Younger Patients
This study looks at colorectal cancer in younger patients who wouldn't normally be screened. Researchers want to understand how this cancer develops in people under the typical screening age.
Dallas, TexasAges 35 years+ - NCT07551596RecruitingPhase 2
Two immunotherapy drugs for colorectal cancer with residual disease
This trial tests a combination of two immunotherapy drugs to see if they can stop colorectal cancer from returning after standard treatment. It is for people who still have cancer DNA in their blood after surgery and/or chemotherapy, which means they are at high risk of the cancer coming back.
New Orleans, LouisianaAges 18 years+ - NCT07525206RecruitingPhase 3
Combination treatment for advanced colorectal cancer
This trial tests a new drug combination for colorectal cancer that has not responded to other treatments. It compares the new drug with a standard treatment to see which is more effective.
Goodyear, ArizonaAges 18 years+ - NCT07520578RecruitingPhase 3
Doctor Support to Complete Colon Screening After Positive Test
This study tests whether early information and encouragement from your primary care doctor helps you complete a follow-up colonoscopy after an abnormal screening test for colorectal cancer. The goal is to reduce delays and ensure people get the care they need quickly.
Tours, FranceAges 50–75 - NCT06522919RecruitingPhase 2
Immunotherapy and chemotherapy for advanced colorectal cancer
This trial tests a sequence of treatments for people with a specific type of advanced colorectal cancer (called pMMR or MSS) that has not responded to earlier therapies. Patients first receive an immunotherapy combination (pembrolizumab plus a personalized dendritic cell vaccine) followed by a chemotherapy pill (trifluridine/tipiracil) plus bevacizumab. The goal is to see if this sequence can help control the cancer.
Meldola, Forlì CesenaAges 18 years+ - NCT06620627Recruiting
Blood test for early cancer detection before colonoscopy
This study is testing a new blood test that might help find cancer early. If you are 40 or older and planning a routine screening colonoscopy, you may be able to join. You will give a blood sample before the colonoscopy, and the researchers will see if the test can detect signs of cancer.
Austin, TexasAges 40 years+ - NCT06799793Recruiting
AI screening for early colorectal cancer detection
This study uses an artificial intelligence model to analyze test results from the fecal immunochemical test (FIT) to help find colon cancer early. You may benefit if you are 50-69 and had a positive FIT result as part of a screening program.
Bologna, BolognaAges 50–69 - NCT07447050RecruitingPhase 2
Riluzole to Prevent Chemo-Related Cognitive Problems
This pilot study tests whether the drug riluzole can help prevent the thinking and memory problems (often called 'chemobrain') that some people experience during chemotherapy. If you are about to start a chemo regimen containing an anthracycline or platinum drug, you may be able to join.
Orange, CaliforniaAges 18 years+ - NCT07436637Recruiting
Blood test for colorectal cancer screening
This trial is testing a blood test called Guardant Shield to see if it can effectively screen for colorectal cancer (a common cancer of the colon or rectum). If you're between 45 and 85 and overdue for a screening, this test could be a simpler alternative to colonoscopy or stool tests.
Miami, FloridaAges 45–85 - NCT07433283RecruitingPhase 1/Phase 2
Iron nanoparticle injection for advanced solid tumors
This trial tests a new treatment for advanced solid tumors that uses tiny iron particles guided by carbon nanoparticles, injected directly into the tumor. It may be an option if standard treatments have stopped working or aren't available, and you have a tumor that can be safely injected.
Beijing, Beijing MunicipalityAges 18–80 - NCT06640166RecruitingPhase 2
Encorafenib + Cetuximab with FOLFIRI after progression
This trial tests adding a new chemotherapy regimen (FOLFIRI) to the combination of Encorafenib and Cetuximab for people with a specific type of advanced colorectal cancer that has started growing again after initial treatment with Encorafenib and Cetuximab. The goal is to see if the new combination can help control the cancer longer.
MilanAges 18 years+ - NCT07407465RecruitingPhase 2
Study of a new drug combo for advanced HER2-positive colorectal cancer
This trial tests a combination of three drugs (trastuzumab deruxtecan, capecitabine, and bevacizumab) as the first treatment for people with HER2-positive colorectal cancer that has spread or cannot be removed by surgery. The goal is to see if this combination can shrink tumors and help patients live longer.
LyonAges 18 years+ - NCT06282445RecruitingPhase 2
Combination therapy for first-line metastatic colorectal cancer
This trial tests whether adding the immunotherapy drug adebrelimab to standard chemotherapy plus bevacizumab can help people with a specific type of metastatic colorectal cancer that cannot be removed by surgery. It is for patients whose tumors are microsatellite stable (MSS) or have normal mismatch repair (pMMR).
Jinhua, ZhejiangAges 18–75 - NCT07393906Recruiting
Eat right, screen right for colorectal cancer prevention
This study looks at how healthy eating and regular screening can help prevent colorectal cancer. You may join if you are an adult who can use a computer or mobile device.
Gainesville, FloridaAges 18 years+ - NCT06703632Recruiting
Testing a new stool test for early colon cancer detection
This study is evaluating PreveCol, a new second-line stool test for people aged 50–69 who had a positive FIT/FOBT result and are already scheduled for a colonoscopy. It aims to find out if this test can help detect colorectal cancer earlier.
Lisbon, Lisbon DistrictAges 50–69 - NCT07361614Recruiting
Colorectal cancer education program
This study tests a program to help people learn about colorectal cancer screening. If you are 45 to 75 and due for screening, you may be able to join.
New York, New YorkAges 45–75 - NCT07345676Recruiting
Helping patients complete colorectal cancer screening
This trial is testing a simple program to help people who are due for colorectal cancer screening to complete their test. It's for patients at Cornell Scott Hill Health who either haven't finished a screening order or had an abnormal stool test without follow-up.
New Haven, ConnecticutAges 45–75 - NCT07341737RecruitingPhase 1/Phase 2
SL-28 for advanced solid tumors that haven’t responded to treatment
This trial tests a new drug, SL-28, for people with advanced solid tumors that haven’t responded to or cannot be treated with standard therapies. It aims to find a safe dose and see if the drug can help shrink or slow the growth of your cancer.
Sydney, New South WalesAges 18 years+ - NCT07328087RecruitingEarly Phase 1
Personalized colon cancer vaccine trial for MSS stage 3 patients
This trial tests a custom-made vaccine designed from your tumor's genetic material. The vaccine is given alongside standard chemotherapy and an immunotherapy drug to try to prevent the cancer from coming back. It is for people with stage 3 colorectal cancer that has been fully removed by surgery and has certain high-risk features.
ThessalonikiAges Any age - NCT07321106RecruitingPhase 1
CBI-1214 for advanced colorectal cancer
This trial tests a new drug called CBI-1214, which is designed to help your immune system attack cancer cells. It is for people with advanced colorectal cancer that has not responded to other treatments.
Phoenix, ArizonaAges 18 years+ - NCT05346757Recruiting
Test stool DNA changes to screen or find colorectal cancer
This study checks whether a stool test that looks for tiny genetic signals can help detect colorectal cancer (or find it again after prior findings). You may be asked to provide a stool sample around the time you get a colonoscopy.
BarcelonaAges 18–80 - NCT07254910Recruiting
Study to boost colon cancer screening in American Indians
This study tests a new program to help American Indian adults get screened for colorectal cancer. If you qualify, you may get support and reminders to complete a simple stool test at home.
Oklahoma City, OklahomaAges 45–75 - NCT07244705RecruitingPhase 1/Phase 2
Study of ABT-301 plus tislelizumab and bevacizumab for advanced colorectal cancer
This trial tests a new drug combination (ABT-301, tislelizumab, and bevacizumab) for people with a specific type of advanced colorectal cancer that has not responded to at least two prior treatments. It aims to see if this combination can help shrink tumors or slow the disease.
Liverpool, New South WalesAges 18 years+ - NCT07230795Enrolling by invitation
AI-guided colorectal cancer screening for adults 45-49
This trial tests whether a computer program can help more adults ages 45-49 get screened for colorectal cancer. If you are due for screening and see a Penn Medicine doctor, you may be able to join.
Philadelphia, PennsylvaniaAges 45–49
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Common questions
- Are there clinical trials for colorectal cancer screening?
- Yes. Clin2 currently lists 379 recruiting colorectal cancer screening studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer screening trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer screening trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.