Clinical trials
Constipation - Functional clinical trials
Below are recruiting constipation - functional clinical trials, each written for real people, not researchers. We’re tracking 155 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06562907RecruitingPhase 1
Study of an experimental drug for weight and diabetes
This study tests an investigational drug called GS-4571 in healthy people, people with obesity, and people with type 2 diabetes. It aims to see how the drug affects the body and whether it might help with weight and blood sugar control.
Miami, FloridaAges 18–65 - NCT06515821Recruiting
Improving colorectal cancer screening and diagnosis
This study collects data to improve how colorectal cancer is found and diagnosed. It compares new testing methods (like breath and stool tests) with standard colonoscopy in people with and without cancer or risk factors.
SofiaAges 18 years+ - NCT06478823Recruiting
Healthy stool donors for fecal transplant studies
This trial is looking for healthy stool donors to provide samples for fecal microbiota transplantation, a treatment that uses healthy bacteria from stool to help people with certain gut diseases. As a donor, you would give stool samples regularly to help others.
Paris, ParisAges 18–49 - NCT06475560Recruiting
Camera capsule endoscopy for colorectal disease diagnosis
This trial tests a camera pill (capsule endoscopy) as an alternative to a regular colonoscopy for people with colon or rectum symptoms. It's a simpler way to look inside your large intestine without a tube.
Odense CAges 18 years+ - NCT06442566RecruitingPhase 1/Phase 2
Enhancing opioid therapy for chronic pain with buprenorphine, counseling, and brain stimulation
This study is testing whether adding a medication (buprenorphine), counseling, and a type of brain stimulation (TMS) can improve long-term opioid therapy for chronic pain. If you have been taking prescription opioids daily for at least 3 months and have extra risk factors for opioid-related problems, this trial may offer you new ways to manage pain and reduce risks.
Charleston, South CarolinaAges 18 years+ - NCT06413368RecruitingPhase 2/Phase 3
Maralixibat for cystic fibrosis constipation
This trial tests a medicine called maralixibat to see if it helps children with cystic fibrosis who have chronic constipation that doesn't improve with standard treatments. The goal is to improve bowel movements and quality of life.
Los Angeles, CaliforniaAges 1–18 - NCT06391749Enrolling by invitation
Blood test for multiple cancers in people with symptoms
This trial tests a new blood test (SPOT-MAS) that looks for signs of multiple cancers in people who already have symptoms and are being checked with imaging. If the blood test is positive, you'll get more detailed scans or a biopsy to see if cancer is present.
Ho Chi Minh CityAges 18 years+ - NCT06138821Recruiting
Endoscopic sleeve gastroplasty for obesity and MASH
This study tests if a procedure called endoscopic sleeve gastroplasty helps people with obesity and a liver condition called MASH lose weight and improve their liver health. It might be an option if you have both obesity and MASH and haven't had weight-loss surgery before.
Boston, MassachusettsAges 18 years+ - NCT05412069Recruiting
Test Fecobionics for fecal incontinence in adults
This trial studies whether Fecobionics can improve fecal incontinence (accidents with stool). It also looks at people with both “normal” and “abnormal” patterns of fecal incontinence to see who may benefit most.
San Diego, CaliforniaAges 18–75 - NCT05000996Recruiting
Gut microbiome study for people having metabolic surgery
This study looks at your gut bacteria (your “microbiome”) around the time of metabolic surgery. It may help researchers understand how surgery affects gut health and related conditions like diabetes, blood pressure, and cholesterol.
Nashville, TennesseeAges 21–65 - NCT05998187RecruitingPhase 3
Botox injections for fecal incontinence
This trial tests whether botulinum toxin (Botox) injections into the rectum can improve bowel control in people with active fecal incontinence. It aims to help those who haven't gotten better with standard treatments like diet changes or pelvic floor therapy.
Rouen, FranceAges 18 years+ - NCT05924295Recruiting
Study how ketone changes in the body with diet and fasting
This study looks at how your body processes “ketones,” which are energy molecules that rise with fasting or low carbohydrate intake. You may be asked to follow strict diet and activity rules before test days so researchers can see what affects ketone metabolism.
Novato, CaliforniaAges 20–70 - NCT05889624Recruiting
Study of treatments for childhood migraine headaches
This study looks at ways to help children and teens with migraine headaches by testing a care approach that includes access to evidence-based treatment. It may help if your child has frequent migraine headaches and is starting (or not already on) certain migraine-preventive medicines.
Birmingham, AlabamaAges 10–17 - NCT05905926Enrolling by invitationPhase 3
Tenapanor safety study for teens with constipation-predominant IBS
This trial checks the safety of tenapanor in children and teens (ages 6 to under 18) with IBS-C. It is only for people who finished a previous related study and agreed to continue follow-up.
Foley, AlabamaAges 6–18 - NCT05822141Recruiting
Omega-3 effects on body fat in cold exposure
This study tests whether omega-3 (fish oil–type) changes how your body fat responds when you are exposed to cold. It may help researchers understand how to regulate “brown fat,” which can be involved in how your body uses energy during cold.
Bloomington, IndianaAges 18–40 - NCT05791604Recruiting
Study prebiotics and probiotics to help children with Prader-Willi
This trial studies whether taking prebiotics and probiotics can help children with Prader-Willi syndrome manage obesity. It’s testing a gut-focused approach to weight control over the study period.
Shanghai, Shanghai MunicipalityAges 3–10 - NCT05796388Recruiting
Virtual reality and linaclotide for IBS with constipation
This study tests whether virtual reality (VR) plus linaclotide can improve symptoms and quality of life in adults with IBS-C (IBS with constipation). You may be asked to use VR and take a study medicine, while doctors check that your IBS diagnosis fits strict criteria.
Jacksonville, FloridaAges 18–70 - NCT02390973Recruiting
Bariatric-style surgery vs best diabetes care for long remission
This trial compares surgery plus follow-up care versus the best non-surgical (medical) treatment to help people keep type 2 diabetes in remission for a long time. It may be an option if you have higher body weight and diabetes that’s not well controlled, but safety checks are strict.
Québec, QuebecAges 18–60 - NCT05646901Recruiting
Study how gut bacteria may affect loss of eating control
This study looks at how gut bacteria and the brain may be involved when people struggle to control eating. It may help researchers understand the body’s signals behind eating control problems.
Girona, GironaAges 30–65 - NCT05588154Recruiting
Donate blood and other samples to study blood cancers
This study asks healthy adults to provide blood, bone marrow (if needed), skin, saliva, and stool samples. Scientists use these samples to compare patterns related to myeloid (bone-marrow) blood cancers, which may help future research and tests.
Bethesda, MarylandAges 18–120 - NCT05588323RecruitingPhase 1/Phase 2
Testing naldemedine for constipation caused by opioid pain meds
This study tests whether naldemedine is safe and how the body processes it in children who take opioid medicines and are dealing with constipation or are at risk for it. It may help some children by reducing constipation side effects from opioid pain treatment.
TiranaAges 2–18 - NCT05519683RecruitingPhase 2/Phase 3
Home electrical stimulation for constipation IBS pain
This trial tests whether a home device that uses mild skin electrical stimulation can reduce belly pain from IBS with constipation. It also checks whether the treatment is safe and helpful for symptom relief over the study period.
Ann Arbor, MichiganAges 18 years+ - NCT05539729RecruitingPhase 1
Testing vancomycin for newly diagnosed multiple sclerosis
This Phase 1 study tests whether the antibiotic vancomycin can be given safely to people with newly diagnosed multiple sclerosis (or related early stages). It mainly focuses on safety and side effects, and whether the approach is feasible for this group.
New York, New YorkAges 18–50 - NCT00389142Recruiting
Find genes linked to bladder pain and urinary symptoms
This study looks for genetic (inherited) causes of bladder pain syndrome (IC/BPS), using information from people who have typical urinary symptoms. It may help doctors understand why IC/BPS happens, which could guide better future care.
Boston, MassachusettsAges 1 year+
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Common questions
- Are there clinical trials for constipation - functional?
- Yes. Clin2 currently lists 155 recruiting constipation - functional studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a constipation - functional trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a constipation - functional trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.