Clinical trials
Crohn’s disease clinical trials
A type of inflammatory bowel disease causing inflammation of the digestive tract. We’re tracking 333 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04751396Recruiting
Melanoma education for people with autoimmune conditions
This trial tests an educational tool to help people with melanoma and pre-existing autoimmune disease understand immune checkpoint inhibitor treatment. It aims to support you and your care team with information that can help you make decisions and feel more prepared.
Houston, TexasAges 18 years+ - NCT06113913RecruitingPhase 4
Switching from IV to under-the-skin infliximab after dose increase
This study tests if switching from a high-dose infliximab IV infusion to a daily or weekly injection under the skin works just as well. It is for people with inflammatory bowel disease who are already stable on IV infliximab.
Ghent, Oost-VlaanderenAges 18 years+ - NCT07198113Recruiting
Comparing newer treatments for pediatric inflammatory bowel disease
This study is for children and teens with inflammatory bowel disease (Crohn's, colitis, or indeterminate) whose previous anti-TNF medicine stopped working. It compares several newer treatments to see which works best.
Chapel Hill, North CarolinaAges 1–18 - NCT02791854Enrolling by invitation
Improving Care for Adults With Crohn’s or Ulcerative Colitis
This trial looks at ways to improve care for adults living with inflammatory bowel disease, including Crohn’s disease and ulcerative colitis. You may be invited if your clinic is part of an inflammatory bowel disease care network called IBD Qorus.
Los Angeles, CaliforniaAges 18–99 - NCT05040464RecruitingPhase 3
Azathioprine or methotrexate added to adalimumab for Crohn’s
This trial compares two medicine options (azathioprine vs methotrexate) when added to adalimumab to treat active Crohn’s disease. It may help determine which add-on works better for people whose Crohn’s is still active despite standard treatments or who can’t take them.
AmiensAges 18 years+ - NCT04997733RecruitingPhase 3
Stool transplant to maintain Crohn’s remission after stopping anti-TNF
This Phase 3 study tests whether transplanting stool bacteria can help people with Crohn’s stay in remission after they stop an anti-TNF medicine. It may help some patients who are currently doing well but need to come off anti-TNF treatment.
ParisAges 18–74 - NCT03589183Recruiting
Gut microbiome study for ulcerative colitis and Crohn disease
This study looks at how changes in gut bacteria (the microbiome) relate to inflammatory bowel disease, including ulcerative colitis and Crohn disease. It may help researchers understand what might improve symptoms or disease control.
SeoulAges Any age - NCT07456566Recruiting
Self-management help for inflammatory bowel disease
This trial tests a self-management program for people with active Crohn's disease or ulcerative colitis. It aims to improve quality of life by helping you better manage your condition.
Ann Arbor, MichiganAges 18 years+ - NCT06892990Recruiting
Better imaging for inflammation in bowel disease
This trial tests a new imaging technique that may help doctors see inflammation more clearly during colonoscopy in people with Crohn's disease or ulcerative colitis. The technique is called Texture and Color Enhancement Imaging (TXI).
Ulm, Baden-WurttembergAges 18 years+ - NCT05645055Recruiting
Biologic treatment for bowel narrowing in Crohn’s disease
This trial studies biologic medicines to treat Crohn’s disease that causes bowel narrowing (“strictures”) without needing immediate surgery. It may help reduce symptoms and complications by targeting the immune-driven inflammation behind the narrowing.
Nanjing, JiangsuAges 16–65 - NCT07073079Recruiting
Study of upadacitinib and risankizumab for Crohn's after first therapy
This study tests two oral/ injectable medicines (upadacitinib and risankizumab) in adults with moderate-to-severe Crohn's who have already tried a TNF-blocker. It aims to see how well these treatments work in everyday practice.
Castellana Grotte, BariAges 18 years+ - NCT04330846Recruiting
Study of new narrowing in Crohn’s treated with two approaches
This study looks at treatments for a new (de novo) narrow area in the bowel from Crohn’s disease. It aims to see which treatment works better at relieving blockage-type symptoms for the safest, most effective option.
Badalona, BarcelonaAges 18–80 - NCT07166588Enrolling by invitation
Precision medicine study for inflammatory bowel disease
This study looks at using precision medicine to treat inflammatory bowel disease (IBD) in people who are newly diagnosed or already being monitored. It aims to find better ways to manage the condition.
Seoul, SeoulAges 10 years+ - NCT06579443Recruiting
Robotic surgery study for inflammatory bowel disease
This study looks at how well robotic surgery works for people with inflammatory bowel disease. It aims to help surgeons learn and improve outcomes for patients like you.
Coventry, West MidlandsAges 18 years+ - NCT07582458RecruitingPhase 2/Phase 3
Modafinil for Fatigue in Controlled Inflammatory Bowel Disease
This trial tests whether modafinil (a wakefulness-promoting medication) can reduce severe fatigue in people with inflammatory bowel disease (IBD) whose disease is well-controlled. If you have persistent exhaustion despite your IBD being stable, this study may help determine if this medication works for you.
Arnhem, GelderlandAges 18–75 - NCT03816345RecruitingPhase 1
Nivolumab for advanced cancer with autoimmune disease
This trial tests whether the immunotherapy drug nivolumab can safely treat advanced cancer in people who also have an autoimmune disease like rheumatoid arthritis, lupus, or multiple sclerosis. It aims to find out if the drug may help control cancer while managing their autoimmune condition.
Birmingham, AlabamaAges 18 years+ - NCT06719622Enrolling by invitationPhase 2/Phase 3
Budesonide for Crohn's in the upper gut
This trial tests a budesonide liquid that targets inflammation in the esophagus, stomach, and duodenum (upper digestive tract) in children with Crohn's disease. It aims to see if this treatment can reduce inflammation in those areas without strong side effects.
KrakowAges 6–18 - NCT04973423Recruiting
Testing extra check-ins for Crohn’s using stool tests and MRI
This study checks whether adding an extra, cross-body “transmural” evaluation (looking at inflammation throughout the bowel) improves care for adults with Crohn’s who are starting or receiving biologic (biotherapy) treatment. It uses close follow-up with stool calprotectin (a marker of gut inflammation) to see if this approach helps control inflammation.
AmiensAges 18 years+ - NCT06995170Recruiting
Polyamines and IBD progression study
This study looks at how certain natural chemicals called polyamines relate to the activity of inflammatory bowel disease (IBD). It aims to understand if these chemicals can help predict disease progression.
Xi'an, ShaanxiAges 18–65 - NCT06241170Recruiting
Surgical margin study for Crohn's disease recurrence
This trial tests a specific way of cutting the bowel during surgery for Crohn's disease to see if it lowers the chance of the disease coming back. It is for people with Crohn's in the ileocecal area who are having their first surgery to remove that section.
Guangzhou, GuangdongAges 14–65 - NCT06581328RecruitingPhase 4
Study of vedolizumab for ulcerative colitis or Crohn's disease
This study tests a medication called vedolizumab for people with moderate to severe ulcerative colitis or Crohn's disease. The goal is to see how well it works in a regular community setting, and it may help control symptoms if other treatments haven't worked.
Birmingham, AlabamaAges 18–80 - NCT07616687RecruitingPhase 4
Testing guselkumab to improve Crohn's disease control
This study tests whether guselkumab, a newer biologic medication, can better control active Crohn's disease symptoms and inflammation. You'll receive the medication and be monitored closely to see how well it works for you.
AmiensAges 18 years+ - NCT07441447Recruiting
Muscle strength and mass in inflammatory bowel disease
This study looks at muscle strength and muscle mass in people with inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis. It aims to understand how IBD affects muscles, which can help improve patient care.
Sakarya, AdapazarıAges 18 years+ - NCT07352995Enrolling by invitation
Gut temperature study during colonoscopy
This study uses a special probe to measure temperature inside the colon during a routine colonoscopy. It may help researchers understand conditions like IBD, Crohn's disease, and ulcerative colitis.
Boston, MassachusettsAges 18 years+
Hear when a new Crohn’s disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for crohn’s disease?
- Yes. Clin2 currently lists 333 recruiting crohn’s disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a crohn’s disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a crohn’s disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.