Clinical trials
Cryoablation clinical trials
Below are recruiting cryoablation clinical trials, each written for real people, not researchers. We’re tracking 64 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06127303RecruitingPhase 2
Toripalimab plus cryoablation for lung cancer with limited progression
This trial tests a combination of an immunotherapy drug (toripalimab) and a freezing treatment (cryoablation) for people with advanced non-small cell lung cancer that has started to grow again in only a few spots after initial treatment. It aims to see if this approach can help control the cancer without switching to a completely new therapy.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06224283Recruiting
Predicting desmoid tumor growth after cryoablation
This study looks at whether a special MRI analysis (radiomics) can better predict if a desmoid tumor will grow back after freezing treatment (cryoablation) compared to standard methods. It may help doctors decide on future treatment steps.
BolognaAges Any age - NCT06246968RecruitingPhase 1
Pembrolizumab and Cryoablation for Breast Cancer
This trial is testing a combination of a freezing procedure (cryoablation) and an immunotherapy drug called pembrolizumab (Keytruda) for people with triple-negative breast cancer that has spread. The goal is to see if freezing the tumor helps the immune system fight the cancer better.
Basking Ridge, New JerseyAges 18 years+ - NCT06253000Recruiting
Heat vs. Freezing for the Back of the Heart
This trial tests two ways to treat the back wall of the heart's left chamber in people with stubborn atrial fibrillation. It compares radiofrequency (heat) and cryoablation (freezing) to see which is safer and works better.
MoscowAges 18–80 - NCT06278987RecruitingPhase 4
Comparing two pain relief methods for hip fracture surgery
This study compares two ways to manage pain after hip fracture surgery: a new type of injection near the hip joint (cryoablation of the PENG nerve group) versus a standard numbing catheter placed in the groin area (fascia iliaca catheter). The goal is to see which method provides better pain relief and recovery.
Minneapolis, MinnesotaAges 18–85 - NCT06300125Recruiting
Freezing small low-risk breast tumors without surgery
This trial tests cryoablation (freezing the tumor with a needle) as a way to treat small, low-risk breast cancers without surgery. It is for women 50 or older whose cancers are hormone-receptor-positive and haven't spread to lymph nodes.
MilanAges 50 years+ - NCT06682208Recruiting
Pain relief catheter vs freeze ablation for pectus surgery recovery
This trial compares two ways to manage pain after the Nuss procedure for pectus excavatum. One uses a special catheter that numbs nerves, the other freezes them. The goal is to see which works better for teens and young adults.
Cincinnati, OhioAges 12–21 - NCT06698159Recruiting
Wider pulmonary vein isolation in AFib ablation with single-shot cryoablation
This study tests a new approach to a common procedure for atrial fibrillation (AFib) called pulmonary vein isolation. It uses a single-shot cryoablation technique to treat people with paroxysmal or persistent AFib.
Pozzilli, IserniaAges 18 years+ - NCT06839001RecruitingPhase 3
Freezing small breast tumors instead of surgery trial
This study tests if freezing a very small early-stage breast tumor (cryoablation) can be as effective as surgery. It may be an option for people whose tumor is small enough and hasn't spread to lymph nodes or elsewhere.
São Paulo, São PauloAges 18 years+ - NCT06854250RecruitingPhase 2
Cryoablation and low-dose chemo for metastatic prostate cancer
This trial tests freezing prostate tumors (cryoablation) combined with a low-dose chemotherapy pill (metronomic cyclophosphamide) for men with metastatic prostate cancer. The goal is to see if this combination can slow the cancer's growth and improve outcomes.
Guangzhou, GuangdongAges 18–80 - NCT06939127RecruitingPhase 2
Cold therapy, immunotherapy, and chemo before and after lung cancer surgery
This trial tests a treatment that uses extreme cold (cryoablation) along with immunotherapy (tislelizumab) and chemotherapy before and after surgery for people with early-stage lung cancer that can be removed. The goal is to see if this combination helps prevent the cancer from coming back.
TianjinAges 18–75 - NCT06991231Recruiting
Cryoablation benefits in knee replacement surgery
This trial tests if a special cold treatment (cryoablation) can help reduce pain or improve recovery for people getting knee replacement surgery for arthritis. It might offer an extra option to feel better after the procedure.
New York, New YorkAges 18 years+ - NCT07070700RecruitingPhase 2
Cryoablation with targeted therapy and immunotherapy for advanced bile duct cancer
This trial tests a combination of cryoablation (freezing tumors), lenvatinib (a targeted therapy), and QL1706 (an immunotherapy) for people with advanced intrahepatic cholangiocarcinoma (bile duct cancer) that has worsened after initial treatment. The goal is to see if this combination can help stop the cancer from growing.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07204132Recruiting
Freezing and Immunotherapy for Bladder Cancer
This study tests a combination treatment for people with early-stage bladder cancer who want to avoid bladder removal. It uses a freezing technique (cryoablation) inside the bladder along with immunotherapy drugs to see if this can cure the cancer while keeping the bladder.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT07232433Recruiting
Freezing treatment for lung ground-glass nodules
This study tests a freezing treatment (cryoablation) for lung nodules that look like ground glass and are confirmed to be cancer. It's for people who cannot or choose not to have surgery or radiation.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07301411Recruiting
Freezing lung tumors guided by a breathing tube camera
This study tests a new way to freeze and destroy small lung tumors using a thin tube with a camera (bronchoscope) to guide the freezing probe. It is for people with early-stage lung cancer or limited lung metastases who cannot or prefer not to have surgery or radiation.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT01788410Recruiting
MRI-guided freezing treatment for neck, head, and spine pain
This trial studies an MRI-guided procedure that “freezes” targeted nerves or joints to reduce pain in the head, neck, or spine. It may help if your pain comes from a joint problem or a compressed/damaged nerve and you can safely have MRI scans before and after the treatment.
Boston, MassachusettsAges 18 years+ - NCT07447414Recruiting
Freezing small hormone-driven breast cancers
This study tests cryoablation (freezing) to treat small, early stage breast cancers that are hormone receptor positive and HER2 negative. It may be an option for postmenopausal women who want to avoid surgery.
Lugo, LugoAges Any age - NCT05415384Recruiting
Cryotherapy plus surgery for broken ribs
This trial tests whether adding cryotherapy (freezing treatment to the injury area) to standard surgery for broken, displaced ribs can improve recovery. It’s for adults with multiple broken ribs who are getting a surgical stabilization procedure soon after injury.
Winston-Salem, North CarolinaAges 18–80 - NCT07602049RecruitingPhase 2
Freezing Plus Immunotherapy for Advanced Soft Tissue Sarcoma
This trial combines cryoablation (a freezing technique to destroy tumors) with camrelizumab (an immunotherapy drug that helps your immune system fight cancer) for patients with advanced soft tissue sarcoma that hasn't responded to standard treatments. The goal is to see if this combination works better than current options.
Guangzhou, GuangdongAges 14–70 - NCT07671898Recruiting
Freezing vs. Radiofrequency for Slow Heart Rate
This trial compares two procedures to treat very slow heart rates without needing a pacemaker. One uses freezing (cryoablation) and the other uses radiofrequency energy to target nerves that control heart rate.
Tomsk, Tomsk OblastAges 18–60 - NCT06753617Enrolling by invitation
Cold probe treatment for brain tumors
This trial tests a cold-based treatment (cryoablation) for certain brain tumors including gliomas, meningiomas, and metastases. It may be an option if you plan to have surgery and meet safety criteria.
Rotterdam, South HollandAges 18–80 - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT07650032Recruiting
Freezing Treatment for Abnormal Heart Rhythms
This trial tests a freezing catheter procedure to treat dangerous, recurring abnormal heart rhythms (ventricular tachycardia) in patients whose hearts are weakened and whose current medications haven't worked. The procedure aims to scar the tissue causing the arrhythmia so your heart beats normally again.
Phoenix, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for cryoablation?
- Yes. Clin2 currently lists 64 recruiting cryoablation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cryoablation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cryoablation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.