Clinical trials
Degenerative Joint Disease clinical trials
Below are recruiting degenerative joint disease clinical trials, each written for real people, not researchers. We’re tracking 32 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06506656Recruiting
Testing Hyadrol gel for hip or thumb arthritis pain
This study tests whether a combination of hyaluronic acid and adelmidrol (a gel called Hyadrol) can reduce pain and improve joint function in people with arthritis of the hip or thumb. It may help if you have persistent pain and are not already on other treatments.
RomaAges 40 years+ - NCT06320899Recruiting
Comparing different rods for lower back spine surgery
This study tests two types of rods (mid/high-flex vs low-flex) used during back surgery for people with degenerative spine problems in the lower back. The goal is to see which type helps reduce pain and improve movement better.
AarbergAges 18–99 - NCT06778447Recruiting
Disc injection for chronic low back pain
This study tests whether injecting a special disc material (nucleus pulposus allograft) into the damaged discs of your lower back can safely reduce pain and improve function. It's for people with long-term, moderate to severe low back pain from disc disease that hasn't gotten better with other treatments.
Napa, CaliforniaAges 22–85 - NCT07199738Recruiting
Knee replacement study with a new implant option
This study tests a specific knee implant insert (LEGION Medial Stabilized) in people who need a total knee replacement due to arthritis or similar joint disease. It aims to see if the device is safe and works well over time.
Newton, MassachusettsAges 18–80 - NCT03048201Recruiting
Total Knee Replacement Registry Study for a Specific Knee Implant
This study tracks outcomes for people getting a total knee replacement using a specific knee implant system. It may help doctors understand which patients do best and how the implant performs over time.
Rancho Mirage, CaliforniaAges 22 years+ - NCT05357378Recruiting
Hip replacement study using a reverse hip implant
This trial looks at how safe and well a specific “reverse” hip implant works in people who need their first total hip replacement. It may help by improving pain and hip function, while closely tracking safety during and after surgery.
Miami, FloridaAges 50–75 - NCT06108934Recruiting
Study of the Insignia Hip Stem for First Hip Replacement
This study tests a new cementless hip stem (Insignia) for people having their first total hip replacement. It aims to see how long the implant lasts and how well your hip works after surgery.
Subiaco, Western AustraliaAges 18 years+ - NCT06920459Recruiting
Zimmer Biomet Shoulder Replacement Study
This study is testing a shoulder replacement system made by Zimmer Biomet to see how well it works for people with severe shoulder problems, like arthritis or fractures. If you qualify, you would receive the implant and be asked to come back for regular checkups to track your recovery.
PforzheimAges 20 years+ - NCT07125833Recruiting
Cold therapy for shoulder replacement pain
This trial tests if freezing a nerve near the shoulder before surgery can reduce pain after a reverse total shoulder replacement. It may help you recover with less discomfort.
Rockwall, TexasAges 30–85 - NCT07267793Recruiting
Long-term study of CartiPRO for knee pain
This trial tests a treatment called CartiPRO for knee pain caused by osteoarthritis or cartilage damage. It looks at how well the treatment works over a long period and is for people who have a certain type of knee pain that hasn't improved with other treatments.
Seongnam-si, Bundang-guAges 19 years+ - NCT07533188Recruiting
Robotic Knee Replacement Surgery Alignment Techniques Study
This study compares two different ways surgeons can align and position a robotic knee replacement to see which gives better results. You'll be randomly assigned to one approach and tracked over time to measure pain, function, and satisfaction.
SingaporeAges 18 years+ - NCT06451588RecruitingPhase 2
Fecal transplant for inflammatory back pain
This study tests whether a fecal microbiota transplant (a procedure that transfers healthy bacteria into your gut) can reduce inflammation and improve symptoms in people with inflammatory back pain (axial spondyloarthritis). It may help if your current treatments are not working well enough.
TromsøAges 18–65 - NCT05227924Recruiting
Testing safety and performance of a hip implant device type
This study checks how safe and well a specific brand of hip implant (SYMBOL range) works in people getting a total hip replacement. It may help by confirming the device performs as expected for primary or revision surgeries.
BeaumontAges 18 years+ - NCT06485206Recruiting
Hybrid disc replacement and fusion for two-level neck disease
This study tests a combination of a disc replacement (Mobi-C) and a spinal fusion (ACDF) for people with degenerative disc disease at two levels in the neck. The goal is to see if this approach is safe and effective for relieving pain and nerve symptoms.
Sacramento, CaliforniaAges 22–69 - NCT05327972RecruitingPhase 2
Botox injections for painful degenerative rotator cuff disease
This Phase 2 study tests whether botulinum toxin (Botox) injections can reduce pain from long-lasting degenerative rotator cuff problems. You may be eligible if you have shoulder pain for over a month and ultrasound evidence of specific tendon irritation.
Paris, ParisAges 41 years+ - NCT06579547Recruiting
Testing MRI instead of CT for joint imaging
This study tests if a new, radiation-free MRI method can replace standard CT scans for checking joint problems like arthritis. You would get both an MRI and a CT scan, and researchers compare the results to see if the MRI works just as well without radiation.
ZurichAges 18 years+ - NCT04775537Recruiting
OssiMend bone graft for lumbar spine fusion surgery
This trial studies whether OssiMend bone graft helps heal a lumbar spine fusion for people whose disc disease has not improved with non-surgical care. It may be an option if you need back surgery due to specific spine wear-and-tear changes.
Encinitas, CaliforniaAges 18 years+ - NCT06462729RecruitingPhase 1/Phase 2
Testing a new bone graft for lower back fusion surgery
This trial tests a new bone graft material called LDGraft for people who need a single-level lower back fusion (anterior lumbar interbody fusion). It aims to see if the new graft is as good as or better than current options for helping bones heal together.
Fort Wayne, IndianaAges 22–80 - NCT07790328Recruiting
Long-term safety of the IntraSPINE implant for low back pain
This study checks how safe and effective the IntraSPINE implant is over time for people with low back pain from degenerative discs. The implant is placed in your spine to support it, and this trial helps see if it continues working well for years.
SaranAges 18 years+ - NCT07491575Recruiting
Evaluation of the 5C MEDic knee replacement system
This study tests a new knee replacement system (the 5C® MEDic Knee) in people having knee surgery at Leuven University Hospital. It aims to see how well the implant works for conditions like arthritis, fractures, or revision of a previous knee replacement.
Leuven, Vlaams-BrabantAges 18 years+ - NCT05548972Enrolling by invitation
Follow-up study of a hip replacement to improve implant wear
This study checks how well a specific hip replacement bearing surface (called dual mobility with Vivacit-E or Longevity) performs over time in real-world patients. It may help people by tracking long-term safety and performance to guide better hip replacement choices.
Little Rock, ArkansasAges 18–80 - NCT04816773Enrolling by invitation
Long-term follow-up for specific knee replacement parts
This study follows people for up to 10 years after a knee replacement done with specific manufacturer parts. It helps the company and doctors understand how well these knee implants work and whether they cause any long-term problems.
Fremont, CaliforniaAges 21 years+ - NCT04147559Enrolling by invitation
Long-term follow-up for a specific hip replacement stem
This study checks how well a particular hip replacement stem (the PROFEMUR Preserve Classic Femoral Stem) and matching parts keep working over many years. You may be invited if you had that exact hip replacement combination and can return for long-term checkups.
Scottsdale, ArizonaAges 21 years+ - NCT03576573Enrolling by invitation
Follow-up study for specific hip replacement components
This study checks outcomes after a specific type of hip surgery using specific brand parts. You may help by sharing follow-up visit information so the sponsor can confirm the components work as expected in everyday patients.
BuxtehudeAges 21 years+
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Common questions
- Are there clinical trials for degenerative joint disease?
- Yes. Clin2 currently lists 32 recruiting degenerative joint disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a degenerative joint disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a degenerative joint disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.