Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06788249RecruitingEarly Phase 1
Ketamine for treatment-resistant depression brain study
This trial tests whether a single dose of ketamine can quickly improve depression by studying brain chemical changes using MRI. It's for people with treatment-resistant depression who haven't used ketamine before.
Philadelphia, PennsylvaniaAges 25–65 - NCT06784908Recruiting
Stress and pain study for people living with HIV
This study looks at how stress affects pain in people with HIV. It may help find better ways to manage pain in this group.
New Haven, ConnecticutAges 18–68 - NCT06782724RecruitingPhase 2
Psilocybin therapy for distress in advanced illness
This trial tests whether a single dose of psilocybin (a psychedelic medicine) can help reduce depression and distress in people with advanced lung disease, ALS, multiple sclerosis, or Parkinson's. You would receive preparation, the drug, and follow-up support in a safe, supervised setting.
PragueAges 18 years+ - NCT05973643Recruiting
Metabolomics study during ECT for depression
This study measures changes in your blood and/or body chemistry while you receive electroconvulsive therapy (ECT) for a severe mood episode. The goal is to understand biological signals related to ECT and treatment-resistant depression, which may help improve future care.
BronAges 18 years+ - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Phoenix, ArizonaAges 18–70 - NCT06205147Recruiting
Elastic band exercise for strength and mood in older hospital patients
This study tests whether using elastic bands for resistance exercises can help older adults in the hospital improve their muscle strength and reduce symptoms of depression. If you are 65 or older, staying in the hospital for more than a week, and able to follow simple instructions, this might be a good fit.
Taipei, TaiwanAges 65 years+ - NCT06049420Recruiting
Lifestyle medicine for rural patients with chronic disease
This trial tests whether exercise therapy can help people with two or more chronic conditions like obesity, diabetes, or heart disease. It's designed for rural patients and requires a referral from your doctor.
Lewisburg, West VirginiaAges 18–64 - NCT06768749Recruiting
Melatonin lotion for better sleep and mood
This trial tests whether using a scented melatonin lotion before bed can improve sleep and reduce anxiety or depression symptoms. It may be a good fit if you have mild sleep problems and some mood symptoms but are not currently taking medication for them.
Redlands, CaliforniaAges 18–21 - NCT06758518Enrolling by invitation
Carpal tunnel syndrome in medical students: stress and depression
This study looks at how stress and depression might affect carpal tunnel syndrome in medical students. It could help us understand if emotional health plays a role in this common wrist condition.
Ioannina, EpirusAges Any age - NCT06755710Recruiting
Patient engagement study for PTSD treatment
This trial tests whether a program that helps people actively take part in their PTSD treatment leads to better outcomes. It is designed for adults with PTSD, including refugees, and aims to improve treatment engagement and results.
Ballerup Municipality, Capital RegionAges 18 years+ - NCT06752369Recruiting
Online program for teens with type 1 diabetes and depression
This study tests a short online program to help teens with type 1 diabetes who feel down. It aims to see if a few sessions can improve mood and diabetes management.
Orlando, FloridaAges 12–17 - NCT05762250Recruiting
Ear acupuncture for symptom relief in advanced cancer
This study tests whether auricular (ear) acupuncture can reduce ongoing symptoms and daily limitations in people with advanced cancer. It may help with discomfort and other side effects related to the disease or its treatment.
StuttgartAges 18–70 - NCT05908565Recruiting
Digital therapy program for Latinx college students in East LA
This study tests a digital (online) prevention and therapy program called STAND to see if it improves engagement and outcomes. You may be able to participate if you’re a Latinx student at East Los Angeles College and can complete online assessments.
Los Angeles, CaliforniaAges 18–40 - NCT06745349Recruiting
Online sleep course for adults in Saskatchewan
This study tests an online sleep course for adults who have trouble falling or staying asleep. It aims to help improve sleep without requiring in-person visits.
Regina, SaskatchewanAges 18 years+ - NCT06749392Recruiting
Depression treatment based on your brain's activity
This study tests a personalized treatment for depression that uses your brain's electrical activity (EEG) to guide therapy. You attend sessions where we monitor your brain's response to help improve your mood.
HaifaAges 18–65 - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
Phoenix, ArizonaAges 18–50 - NCT06557642Recruiting
Laughing Gas and Emotional Thinking Study
This study tests how nitrous oxide (laughing gas) affects your emotions and thinking. It's looking for healthy volunteers ages 18 to 40 to see how the gas might change emotional processing.
OxfordAges 18–40 - NCT06266611RecruitingPhase 2
Cannabis for cancer symptom relief
This trial tests whether cannabis can help cancer patients manage symptoms like sleep trouble, pain, and mood changes. It's for people who are new to using cannabis for these issues.
Aurora, ColoradoAges 25 years+ - NCT04084795Recruiting
EMDR plus brain stimulation for fibromyalgia pain and stress
This trial tests whether combining EMDR therapy with a mild form of brain stimulation can reduce fibromyalgia symptoms, including pain and trauma-related emotional distress. It may help people whose fibromyalgia is closely linked to past trauma and current anxiety or depression.
Barcelona, CataloniaAges 18–70 - NCT06726304Enrolling by invitation
Increasing physical contact for mothers with anxiety or depression
This study tests whether using a baby carrier more often helps mothers with anxiety or depression feel more connected to their babies. It is for mothers who had a healthy baby and were diagnosed with anxiety or depression during pregnancy.
Montreal, QuebecAges 18 years+ - NCT06725277Recruiting
Observing ketamine and Spravato for depression
This study follows people who are already taking or about to start IV ketamine or Spravato® for hard-to-treat depression. Researchers want to learn more about how these treatments work in real life.
Milford, ConnecticutAges Any age - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT06722287Recruiting
Phone support for family caregivers in Thailand
This study tests a mobile program to support the mental health of family caregivers in Thailand. You participate from home using your phone.
BangkokAges 18–80 - NCT06725160Recruiting
Happiness coaching for moms and their young children
This trial tests a program that helps mothers with depression learn positive parenting skills to boost their child's emotional well-being. If you are a mother with high depressive symptoms and have a child between 4 and 6 years old, this study may be an option.
Pittsburgh, PennsylvaniaAges 4–99
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,419 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.