Clinical trials
Depression Disorders clinical trials
Below are recruiting depression disorders clinical trials, each written for real people, not researchers. We’re tracking 689 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06559826RecruitingPhase 2
Ketamine therapy with or without talk for depression
This study compares ketamine alone to ketamine combined with psychotherapy for treating depression. It may help if you have moderate to severe depression and want to see if adding talk therapy improves results.
New York, New YorkAges 18–90 - NCT06610305RecruitingPhase 4
Hormones, mood, and reward in women with PMS-related depression
This study looks at how changes in hormone levels during the menstrual cycle affect mood and the brain's reward system in women with depression that gets worse before their period. The goal is to understand why this happens so better treatments can be developed.
Chapel Hill, North CarolinaAges 18–45 - NCT06700902Recruiting
Support program for college students with mental health challenges
This study tests a program called 'Taking Action' to help college students with serious mental illnesses manage their health and daily life. If you're a student with a mental health condition, you may be able to join to learn new coping skills through group education.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07685925Enrolling by invitation
Health study for 2026 medical interns
This study tracks medical interns during their first year using a smartphone app. It aims to understand how internship affects health.
Ann Arbor, MichiganAges 18 years+ - NCT06766526Recruiting
Online support for emotional adjustment after prostate cancer
This trial tests an online support program to help men cope with emotional distress after prostate cancer. You participate from home using a computer or smartphone.
LinköpingAges 18 years+ - NCT06976840Recruiting
Rapid antidepressant effects of new brain stimulation methods
This trial tests whether two types of non-invasive brain stimulation can quickly improve depression symptoms. It may be an option for adults with major depression who are not currently taking psychiatric medication.
Pittsburgh, PennsylvaniaAges 18–55 - NCT06995807Recruiting
EL-SHIN therapy for depression and stress
This trial tests a new therapy called EL-SHIN for people with moderate depression, anxiety, and stress. It may help if you are a non-Muslim who believes in creationism.
Kuala LumpurAges 18 years+ - NCT07003997RecruitingPhase 2
JAK inhibitor for depression with inflammation
This trial tests a JAK inhibitor (a type of anti-inflammatory drug) for depression that is linked to inflammation. If you have depression or bipolar depression and a high CRP level (a marker of inflammation), you may be eligible.
Atlanta, GeorgiaAges 25–55 - NCT07033780RecruitingPhase 1
Brain stimulation study for depression treatment
This trial tests a new type of brain stimulation called theta-burst stimulation to see if it helps treat depression. It is for people aged 18-50 who are currently experiencing a major depressive episode and are on a stable antidepressant regimen.
Toronto, OntarioAges 18–50 - NCT07087353Recruiting
Remote monitoring for moderate to severe depression
This study tests whether checking in with a mental health team remotely (using your phone) can help people with moderate to severe depression feel better. It’s designed for people who are already getting treatment and want extra support from home.
BesançonAges 18 years+ - NCT07100951Recruiting
Comparing two couples therapies for relationship distress
This study compares two types of couples therapy to see which is better at reducing relationship distress. If you and your partner are feeling unhappy or struggling, and either of you also has symptoms of depression or anxiety, this trial may offer free professional help.
IstanbulAges 24–65 - NCT07113665RecruitingPhase 1
Focused ultrasound brain treatment for severe anorexia
This trial tests if focused ultrasound can help people with severe anorexia nervosa who also have obsessive-compulsive disorder or major depression. It is for those who have not gotten better with other treatments.
Toronto, OntarioAges 18–65 - NCT07130734Recruiting
Digital activity program for young adults with depression
This study tests a smartphone app to help people with depressive symptoms become more physically active. If you are between 19 and 40, feel down or low, and are not very active, this program may support you in getting moving.
Auburn, AlabamaAges 19–40 - NCT07167849Recruiting
Digital help while waiting for therapy
This trial tests a brief digital program for people waiting for outpatient therapy. It aims to provide support during the wait and see if it helps improve mental health symptoms.
BernAges 18 years+ - NCT07212465Recruiting
Brain stimulation for depression in older adults
This study tests a new, faster brain stimulation method for depression in adults aged 60-85 who haven't improved with medication. The treatment targets a part of the brain linked to mood and may offer relief for those who have not found other treatments effective.
Toronto, OntarioAges 60–85 - NCT07221409Recruiting
Virtual reality to help cancer patients feel better during treatment
This trial tests whether using virtual reality can help reduce stress, anxiety, and other emotional symptoms in people being treated for cancer. Patients undergoing chemotherapy, bone marrow transplant, or CAR-T therapy may be eligible.
Jacksonville, FloridaAges 18–90 - NCT07230990Recruiting
Brain Stimulation Study for Depression
This study uses a special type of brain stimulation (rTMS, which uses magnetic pulses) to treat depression. It focuses on part of the brain called the orbitofrontal cortex and aims to understand how stimulating it helps improve mood.
Boston, MassachusettsAges 18–65 - NCT07242105Recruiting
Improving brain activity in depression
This study tests if a type of brain stimulation (TMS) can improve brain function in people with depression. It also includes a small group of epilepsy patients who are already having brain monitoring. The goal is to find new ways to treat depression by targeting specific brain areas.
Iowa City, CaliforniaAges 18–65 - NCT07349706Recruiting
Breathing exercise for dementia risk reduction
This trial tests a simple breathing exercise done for about 5–10 minutes each day for 8 weeks. It aims to see if this exercise can reduce your risk of dementia. If you are between 60 and 80 years old and have at least one risk factor for dementia, this study may be a fit for you.
Tallahassee, FloridaAges 60–80 - NCT07372586Recruiting
Behavioral health support after ICU stay
This study tests a collaborative care model for mental health and recovery after an ICU stay. You might qualify if you visit the MUSC ICU Recovery Clinic within six months of leaving the hospital.
Charleston, South CarolinaAges 18 years+ - NCT07383467Recruiting
Single session help for teens with anxiety or depression
This trial offers a one-time digital self-help program for Hong Kong teens aged 12 to 17 who feel anxious or down. It aims to see if a single session can make a difference.
Hong KongAges 12–17 - NCT07390786Recruiting
Family support program after ICU stay
This study tests a collaborative care program for family members of ICU recovery patients, designed to improve mental health support after a loved one's hospitalization.
Charleston, South CarolinaAges 18 years+ - NCT07485387Recruiting
Korean cognitive aging study using smartphone app
This study looks at how thinking and memory change as people get older. It uses a smartphone app to track these changes over time in healthy older adults living in South Korea.
Seoul, Select One...Ages 60 years+ - NCT07490353RecruitingPhase 1
Can psilocybin help treat loss of pleasure?
This trial tests if psilocybin, a psychedelic substance, can improve the ability to feel pleasure (anhedonia) in people with depression who are not taking antidepressants. It also includes healthy volunteers as a comparison group.
Vienna, State of ViennaAges 18–55
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Common questions
- Are there clinical trials for depression disorders?
- Yes. Clin2 currently lists 689 recruiting depression disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.