Clinical trials
Depression Disorders clinical trials
Below are recruiting depression disorders clinical trials, each written for real people, not researchers. We’re tracking 690 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07490353RecruitingPhase 1
Can psilocybin help treat loss of pleasure?
This trial tests if psilocybin, a psychedelic substance, can improve the ability to feel pleasure (anhedonia) in people with depression who are not taking antidepressants. It also includes healthy volunteers as a comparison group.
Vienna, State of ViennaAges 18–55 - NCT07507370Recruiting
CARED: A fast new treatment plan for depression
This study tests a quick treatment approach for adults with major depression who have not gotten enough help from at least one antidepressant. It aims to see if a new rapid method can improve mood safely.
Chapel Hill, North CarolinaAges 18–70 - NCT07510880Recruiting
Home brain stimulation for major depression
This trial tests a home-based brain stimulation device (tDCS) to treat depression. You would use a headset daily for a few weeks, and the study team will check in to make sure it's working safely and effectively.
L'Hospitalet de Llobregat, BarcelonaAges 18–65 - NCT07539805RecruitingPhase 2
Sertraline Plus Probiotic for Teen Depression
This study tests whether combining sertraline (an antidepressant) with a specific probiotic called Lactobacillus crispatus can safely and effectively treat depression in teenagers. The probiotic may help by improving gut health, which researchers believe could support mental health.
Longgang, Chongqing MunicipalityAges 12–18 - NCT07642882Recruiting
Brain Stimulation for Fibromyalgia Pain Relief
This study tests whether a non-invasive brain stimulation treatment (rTMS) can reduce chronic pain in fibromyalgia patients. The treatment uses magnetic pulses to stimulate specific areas of the brain and may help relieve widespread pain.
Boulogne-Billancourt, Île-de-France RegionAges 18–80 - NCT07645157RecruitingPhase 2
Sertraline and Probiotics for Teen Depression
This study tests whether combining an antidepressant medication (sertraline) with special bacteria supplements (probiotics) can help treat depression in teenagers ages 12–18. Researchers believe the probiotics may help the medication work better by improving gut health.
Chongqing, YuzhongAges 12–18 - NCT07362407Enrolling by invitation
Cannabinoid treatment study for patients in Brazil
This study tracks how cannabis-based medicines work in real life. It looks at how people feel and function while using these treatments prescribed by their doctor.
Florianópolis, Santa CatarinaAges 18 years+ - NCT06880796Enrolling by invitation
Mindfulness therapy for serious mental illness
This trial tests whether mindfulness-based therapy helps people with serious mental illnesses like schizophrenia or mood disorders. You'll learn mindfulness skills in a group setting at your community mental health center.
Providence, Rhode IslandAges 18 years+ - NCT05487911Enrolling by invitation
Brain stimulation (rTMS) for depression symptoms
This trial tests whether a non-surgical brain stimulation technique (rTMS) can reduce depression symptoms in adults with major depression. You would likely have several study visits that include brain scans (MRI) and treatment sessions to see if symptoms improve.
Houston, TexasAges 18–64 - NCT07217860Enrolling by invitationPhase 3
Long-term safety study of azetukalner for bipolar depression
This study is looking at the long-term safety of azetukalner for people with bipolar I or II depression who have already completed a previous trial of this drug. It is an open-label study, meaning everyone will receive the active medication.
Little Rock, ArkansasAges 18–75 - NCT06480500RecruitingPhase 2
Online therapy and IV ketamine for severe depression with suicide risk
This study tests whether adding an online therapy (i-CBT) to intravenous (IV) ketamine is better than IV ketamine alone for people with treatment-resistant depression who are also thinking about suicide. You'll receive either ketamine or a comparison drug (midazolam), plus the online therapy, in a hospital setting.
Toronto, OntarioAges 21–65 - NCT05568498RecruitingPhase 2
Probiotic trial for depression in Parkinson’s disease
This Phase 2 study tests whether taking probiotics can improve depression and mood symptoms in people with Parkinson’s disease. It’s meant for those with mild to moderate depression and stable Parkinson’s and mood treatments.
Vancouver, British ColumbiaAges 40–80 - NCT06656416RecruitingPhase 2
ALTO-100 for bipolar depression
This trial tests an investigational drug called ALTO-100 in people with bipolar I or II who are currently experiencing depression. It looks at whether this new medicine can help improve depression symptoms when taken alongside your usual mood stabilizer or antipsychotic medication.
Chandler, ArizonaAges 18–70 - NCT06560957Recruiting
Timed eating for bipolar depression study
This study tests if a timed eating schedule (eating within a set window each day) can help improve depression symptoms in people with bipolar disorder. The goal is to see if this eating pattern can stabilize mood and energy.
Ottawa, OntarioAges 18–55 - NCT05961306Recruiting
Testing a stepped screening plan during pregnancy and after birth
This study checks how well a step-by-step screening approach and its tools work for identifying issues during pregnancy (weeks 20–24) or in early postpartum (6–10 weeks after delivery). It may help doctors use more accurate screening to decide who needs further care.
Ghent, Oost-VlaanderenAges 18 years+ - NCT06831435Recruiting
Digital therapy for depression study
This study tests if a digital cognitive behavioral therapy program can help treat depression in real-world settings. It is designed for people aged 14 to 60 who have moderate to severe depression symptoms.
Beijing, Beijing MunicipalityAges 14–60 - NCT07073521Recruiting
Cognitive therapy for adjusting to vision loss
This study tests new ways to help people adjust to vision loss using thinking and coping strategies. If you are an adult with vision loss and willing to share feedback, this may be a good fit.
Chicago, IllinoisAges 18 years+ - NCT07217223Recruiting
Home-based brain stimulation for treatment-resistant depression
This study tests whether a gentle brain stimulation technique called tDCS can help people with depression that hasn't improved with medication. It can be done at home using a special headset and an internet connection.
San Diego, CaliforniaAges 18–85 - NCT05763537Recruiting
Study exploring how doulas support pregnancy mood changes
This study looks at how having a doula affects support and wellbeing for people experiencing pregnancy-related mood and anxiety changes. It may help you and others learn what kind of doula support is most helpful during pregnancy.
Missoula, MontanaAges 18 years+ - NCT07745374Recruiting
Deep brain stimulation for bipolar depression
This study tests whether deep brain stimulation (DBS), a surgical treatment that uses electrical pulses to target specific brain areas, is safe and feasible for people with bipolar depression that hasn't improved with other treatments. It may offer a new option for those who have exhausted standard therapies.
New York, New YorkAges 22–70 - NCT05699525Recruiting
Personalized app for cognitive behavioral therapy for young adults
This trial tests a mobile app that delivers personalized cognitive behavioral therapy (a structured talk-therapy approach that helps change unhelpful thoughts and behaviors). It may help reduce symptoms of anxiety, depression, or bipolar disorder for people who fit the study’s timing and safety requirements.
New York, New YorkAges 18–25 - NCT06263738Recruiting
Cold and heat therapy for depression
This trial tests if carefully controlled cold or heat exposure can help lower symptoms of depression. It is open to people with or without depression to see how the body responds to changes in temperature.
Edwards, ColoradoAges 18–65 - NCT07105397Recruiting
AI assistant for managing depression
This study tests a conversational AI system designed to help manage depression. It may recommend treatment changes that are reviewed by a clinician, offering a new way to get support.
Fairfax, VirginiaAges 18–85 - NCT05232032RecruitingPhase 2
Brain scan and medication study for avoiding versus approaching
This Phase 2 study looks at how a medication affects brain activity and real-life mood or anxiety behaviors. It includes people with major depression or several anxiety disorders and also healthy volunteers, using questionnaires, a smartphone, and brain imaging.
Belmont, MassachusettsAges 18–45
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Common questions
- Are there clinical trials for depression disorders?
- Yes. Clin2 currently lists 690 recruiting depression disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.