Clinical trials
Depression Mild clinical trials
Below are recruiting depression mild clinical trials, each written for real people, not researchers. We’re tracking 33 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06273995Recruiting
Behavioral activation through telehealth for teens with depression
This trial tests if a telehealth program can help teenagers with depression feel better by increasing positive activities. You and a caregiver will attend weekly video sessions for 8 weeks.
Houston, TexasAges 12–18 - NCT06735885Recruiting
Brain training with feedback app for depression
This trial tests whether a smartphone app combined with brain scanning (fMRI) can help people with depression. You will get real-time feedback on your brain activity to learn how to improve your mood.
Stanford, CaliforniaAges 18–80 - NCT07237009Recruiting
Personalized reminiscence therapy for memory loss
This trial tests a digital app that uses personal photos and memories to help people with early memory problems feel less depressed or apathetic. It's designed for seniors who have mild cognitive impairment or early dementia.
AngersAges 60 years+ - NCT06751784RecruitingPhase 2
Fampridine's effect on memory in mild to moderate depression
This study tests whether the drug fampridine can improve working memory (like short-term memory and focus) in people with mild to moderate depression. The trial is run by the University of Basel and involves multiple visits.
Basel, Canton of Basel-CityAges 18–55 - NCT06091527Recruiting
Yoga as a treatment for major depression
This trial tests whether practicing yoga alone (without medication or therapy) can help treat major depression. You would attend yoga sessions and learn how it affects your mood.
San Francisco, CaliforniaAges 18 years+ - NCT07652775Recruiting
Brain stimulation and exercise for memory and mood
This study tests whether combining rTMS (a non‑invasive brain stimulation) with aerobic exercise can improve memory, thinking, and mood in older adults who have mild memory problems and depression. It may offer a safe, drug‑free way to help both brain health and emotional well‑being.
Taipei, Taipei CityAges 65–90 - NCT04123314RecruitingEarly Phase 1
Psilocybin study for depression in mild memory or early Alzheimer’s
This early-phase study tests whether psilocybin (a psychedelic substance) can help with depression in people who have mild memory problems or early Alzheimer’s. The trial also closely monitors safety, thinking changes, mood, and blood pressure before and after dosing.
Baltimore, MarylandAges 18–85 - NCT07416747Recruiting
Probiotic supplement with talk therapy for mild to moderate depression
This study tests whether adding a probiotic supplement to supportive talk therapy helps improve symptoms of mild to moderate depression. It may offer an additional option for people who are not currently taking antidepressant medication.
CréteilAges 18–65 - NCT06780917Recruiting
Online cognitive testing for older adults with depression or memory concerns
This study tests whether an online cognitive assessment platform (Creyos) is valid for older adults with major depression or mild cognitive impairment. Participants will complete brain games or puzzles to see how well the online tool measures thinking skills.
Toronto, OntarioAges 60 years+ - NCT07284446Recruiting
Depression, memory, and outcomes in heart failure patients
This study looks at how depression and memory problems affect recovery in people hospitalized with worsening chronic heart failure. It aims to find better ways to support patients during their hospital stay.
KaunasAges 18–85 - NCT05682677Recruiting
Brain stimulation plus cognitive training for depression after mild head injury
This study tests whether a combination of brain stimulation and cognitive training can reduce depression symptoms in people who have ongoing mild traumatic brain injury (TBI). It may help by targeting both mood and thinking/processing skills affected after mTBI.
La Jolla, CaliforniaAges 18–65 - NCT06832605Recruiting
Mindfulness classes by video to prevent depression relapse
This trial tests an 8-week mindfulness-based cognitive therapy program delivered via video call to help people with a history of depression prevent future episodes. It may help you learn skills to manage low mood and reduce the chance of relapse.
Elche, AlicanteAges 18 years+ - NCT07464886RecruitingPhase 3
NAC and mindfulness therapy for depression in youth
This study tests whether a supplement called N-acetylcysteine (NAC) combined with a type of therapy called Mindfulness-Based Cognitive Therapy (MBCT) can help improve depression in teenagers and young adults. It looks at how these treatments affect brain chemicals and may reduce symptoms.
Cincinnati, OhioAges 15–24 - NCT05426967Recruiting
Brain stimulation for depression after mild traumatic brain injury
This trial studies a noninvasive brain treatment (rTMS) to reduce depression symptoms in people with past mild traumatic brain injury from military service. It may help by changing brain activity, while also requiring stable mental health care and regular follow-up.
Palo Alto, CaliforniaAges 18–55 - NCT06390462Recruiting
Counseling for teens in school-based primary care
This study tests a brief counseling approach called Interpersonal Counseling for Adolescents (IPC-A) in school settings. It aims to help teens with emotional or social challenges before they become more serious, and it's designed for those who aren't already in mental health treatment.
HämeenlinnaAges 13–16 - NCT06601140Recruiting
Testing a smartphone app for tracking depression symptoms
This study tests a smartphone-based emotional monitoring device (EMOCARE) to see if it can accurately measure your mood compared to a standard depression questionnaire. It may help researchers find a simpler way to track depression symptoms.
AgenAges 18 years+ - NCT05549102Recruiting
CBT therapy study for anxiety and brain circuit changes
This trial studies whether a specific form of talk therapy (CBT) changes brain activity in people with moderate anxiety. It may help your care team understand what works best and how brain “circuits” respond to treatment.
LondonAges 18–64 - NCT06741540Recruiting
TDCS for breast cancer patients with mild to moderate depression
This trial tests if transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, can help improve mood and treatment outcomes in breast cancer patients with mild to moderate depression who are receiving neoadjuvant chemotherapy before surgery.
Hangzhou, ZhejiangAges 18–65 - NCT07402356Recruiting
Virtual reality eye test for thinking problems
This study uses virtual reality and eye-tracking (pupillometry) to measure thinking and memory problems in people with Alzheimer's, mild cognitive impairment, or depression. It aims to find better ways to detect and track cognitive changes using a simple, non-invasive procedure.
München, BavariaAges 18–80 - NCT05992831Recruiting
Transcranial magnetic stimulation for mild cognitive impairment
This trial tests whether transcranial magnetic stimulation (a noninvasive brain stimulation technique) can help people with mild cognitive impairment (MCI). You and a close contact, like a spouse or friend, will both take part in the study over several sessions.
Charleston, South CarolinaAges 60–85 - NCT06897670Recruiting
Brain blood flow patterns in mood and memory disorders
This study uses a headband with light sensors (fNIRS) to measure blood flow in the brain while you do thinking tasks. It aims to understand differences in brain activity for people with depression, bipolar disorder, or mild memory loss.
Rochester, MinnesotaAges 18 years+ - NCT03665831Recruiting
Deep TMS for depression and memory problems in older adults
This study tests a type of brain stimulation called Deep TMS to help reduce depression and improve or stabilize memory-related symptoms in older adults with Alzheimer’s disease. It’s mainly for people whose depression did not improve or could not be tolerated with antidepressant medicine.
Toronto, OntarioAges 60 years+ - NCT07532551Recruiting
Online Therapy for Anxiety and Depression in Singapore
This study tests an internet-based cognitive behavioral therapy (a self-guided online mental health program) for people with mild-to-moderate anxiety or depression. You'd use an app on your phone or computer to work through lessons and exercises designed to help manage these feelings.
SingaporeAges 21 years+ - NCT06978257Recruiting
Digital happiness skills study for anxiety and low mood
This study tests a smartphone-based program designed to boost positive feelings and reduce worry or low mood. It may help if you have mild to moderate anxiety or depression but are not severely affected or in crisis.
SingaporeAges 21–64
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Depression Mild trials by city
Studies with a site in or near these metro areas.
Depression Mild trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for depression mild?
- Yes. Clin2 currently lists 33 recruiting depression mild studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression mild trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression mild trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.