Clinical trials · Chicago, IL
Depression clinical trials in Chicago
We’re tracking 51 recruiting depression studies with a site in or near Chicago — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Chicago
- NCT06223880RecruitingPhase 4
AXS-05 vs Bupropion to prevent depression relapse
This study tests whether a new drug called AXS-05 can prevent depression from coming back, compared to an older drug called bupropion. If you have major depression and are at risk of relapse, this trial may help you stay well.
Chicago, IllinoisAges 18–65 - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
Chicago, IllinoisAges 18–50 - NCT06408246RecruitingPhase 2
Cognitive training and medication for depression
This study tests whether a combination of cognitive training (brain exercises) and a medication (guanfacine or sertraline) can improve thinking skills in people with depression. It involves MRI scans and computer tasks to understand how your brain responds.
Chicago, IllinoisAges 18–60 - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
Chicago, IllinoisAges 18–75 - NCT05051618Recruiting
Exercise program for depression in people with multiple sclerosis
This trial studies whether a structured exercise program can help reduce symptoms of major depressive disorder in people who also have multiple sclerosis. You’ll complete questionnaires, wear an activity sensor, and do exercise testing while being assigned to the study program.
Chicago, IllinoisAges 18–64 - NCT07073521Recruiting
Cognitive therapy for adjusting to vision loss
This study tests new ways to help people adjust to vision loss using thinking and coping strategies. If you are an adult with vision loss and willing to share feedback, this may be a good fit.
Chicago, IllinoisAges 18 years+ - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
Chicago, IllinoisAges 18–85 - NCT07865052Recruiting
Psychological support before complex stomach or intestinal surgery
This study tests whether a psychological program before major abdominal surgery can help reduce distress and improve recovery. Participants will receive extra mental health support to prepare for their operation.
Chicago, IllinoisAges 18 years+ - NCT06994988Recruiting
Smart band-aid study for chronic pain in women
This trial tests a special band-aid that measures chronic pain. Women with chronic pain or healthy women may join to help researchers learn how this device works.
Chicago, IllinoisAges 18 years+ - NCT06524830RecruitingPhase 2
Testing VLS-01 film for treatment-resistant depression
This trial tests an experimental film placed inside the cheek (VLS-01) against a placebo to see if it helps people whose depression hasn't improved with standard antidepressants. If you have tried at least two antidepressants without success, this study may be an option for you.
Chicago, IllinoisAges 18–65 - NCT07224165Recruiting
Digital support for teens who self-injure
This study tests a digital program (like a smartphone app) to help teens who have been hurting themselves on purpose. The goal is to see if using the app can reduce self-injury and help you feel better.
Chicago, IllinoisAges 14–18 - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Chicago, IllinoisAges 18–70 - NCT06093282Enrolling by invitation
Community activity program for health and mood
This study tests if a community-based activity program can improve both mood and heart health in people who have limited access to healthcare or live in less-resourced neighborhoods. You may be able to join if you have symptoms of depression and are not very physically active or have a higher body weight.
Chicago, IllinoisAges 18 years+ - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Chicago, IllinoisAges 18–85 - NCT07775300RecruitingPhase 3
Study of an injectable drug for major depressive disorder
This study tests an investigational drug called brenipatide for major depressive disorder. It is given as a self-injection and is being compared to a placebo to see if it helps improve depression symptoms in people who are already on standard treatment.
Chicago, IllinoisAges 18–75 - NCT06526078Recruiting
Combining brain training with ketamine for depression
This study tests if adding computer-based cognitive training to ketamine treatment can improve mood in people with depression that hasn't responded to other treatments. It aims to see if the combination works better than ketamine alone.
Chicago, IllinoisAges 18–80 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Chicago, IllinoisAges 18–64 - NCT07346183Recruiting
Text messages and peer support for dementia caregivers
This study tests a program that sends helpful texts and connects you with a trained peer caregiver who has been through similar experiences. It aims to make caring for someone with dementia easier and less stressful.
Chicago, IllinoisAges 18 years+ - NCT06830044RecruitingPhase 3
Adding an experimental drug for major depression
This trial tests if adding a new medicine called milsaperidone can help people with major depression who haven't gotten enough relief from their current antidepressant. It aims to see if the combination works better than the antidepressant alone.
Chicago, IllinoisAges 18–65 - NCT06987799Recruiting
Mindfulness for stress and high blood pressure
This study tests if a mindfulness program can help lower stress and blood pressure in people living in Chicago's South Side. You may join if you have high blood pressure and feel down or depressed.
Chicago, IllinoisAges 18 years+ - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Chicago, IllinoisAges 18–74 - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Chicago, IllinoisAges 10–17 - NCT06636058Recruiting
Digital treatment for weight and mood in adults 50+
This study tests a digital program that helps with weight loss and depression at the same time. It is designed for Black, Hispanic, and other adults over 50 who carry extra weight and feel down.
Chicago, IllinoisAges 50–74 - NCT07713849Recruiting
Transition care for recent psychosis
This study tests a program to help people recently diagnosed with psychosis (within the last two years) transition from hospital to community care. If you have a psychotic disorder and a caregiver involved in your discharge planning, this could help you.
Chicago, IllinoisAges 18–40
Hear when a new Depression trial opens near Chicago, IL
We’ll email you when one opens near Chicago, IL — at most once a week, no account needed, unsubscribe anytime.
Depression trials in other cities
Where these studies are running near Chicago
Institutions with a site for the recruiting depression studies listed above.
- Northwestern University · 4 studies
- University of Illinois at Chicago · 3 studies
- Rush University Medical Center · 2 studies
- Advanced Quality Medical Research /ID# 272902
- Baber Research Group /ID# 232279
- Charter Research
- Chicago Research Center
- Clinical Research Site
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in Illinois.
Common questions
- Are there depression clinical trials near Chicago?
- Yes. We're currently tracking 51 recruiting depression studies with a site near Chicago, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near Chicago?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Chicago to take part?
- Not necessarily. These studies have a site near Chicago, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near Chicago regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.