Clinical trials · Chicago, IL
Depression clinical trials in Chicago
We’re tracking 49 recruiting depression studies with a site in or near Chicago — including Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Chicago
- NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Chicago, IllinoisAges 18–74 - NCT06408246RecruitingPhase 2
Cognitive training and medication for depression
This study tests whether a combination of cognitive training (brain exercises) and a medication (guanfacine or sertraline) can improve thinking skills in people with depression. It involves MRI scans and computer tasks to understand how your brain responds.
Chicago, IllinoisAges 18–60 - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Chicago, IllinoisAges 18–85 - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
Chicago, IllinoisAges 18–85 - NCT06526078Recruiting
Combining brain training with ketamine for depression
This study tests if adding computer-based cognitive training to ketamine treatment can improve mood in people with depression that hasn't responded to other treatments. It aims to see if the combination works better than ketamine alone.
Chicago, IllinoisAges 18–80 - NCT03887715RecruitingTeam says not enrolling
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Chicago, IllinoisAges 18 years+ - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Chicago, IllinoisAges 18–74 - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Chicago, IllinoisAges 10–17 - NCT06261463Recruiting
Peer-led support group for refugee families in Chicago
This study is testing a support program led by trained peers to help refugee families strengthen family bonds and cope with challenges. It is designed for Arabic-speaking families who have recently settled in Chicago.
Chicago, IllinoisAges 12–55 - NCT07610655Recruiting
Nerve Stimulation to Aid Recovery After Spine Surgery
This study tests whether a small device that gently stimulates a nerve in your neck can help you recover better after lumbar spine surgery. The device may help reduce confusion, depression, and other thinking problems that sometimes occur after surgery.
Chicago, IllinoisAges 18 years+ - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Chicago, IllinoisAges 18–70 - NCT06830044RecruitingPhase 3
Adding an experimental drug for major depression
This trial tests if adding a new medicine called milsaperidone can help people with major depression who haven't gotten enough relief from their current antidepressant. It aims to see if the combination works better than the antidepressant alone.
Chicago, IllinoisAges 18–65 - NCT07224165Recruiting
Digital support for teens who self-injure
This study tests a digital program (like a smartphone app) to help teens who have been hurting themselves on purpose. The goal is to see if using the app can reduce self-injury and help you feel better.
Chicago, IllinoisAges 14–18 - NCT06922110Enrolling by invitationPhase 3
Long-term study of azetukalner for depression
This study is for people who already completed a previous trial of azetukalner for major depressive disorder. It tests the long-term safety and effects of continuing the medication.
Chicago, IllinoisAges 18 years+ - NCT06994988Recruiting
Smart band-aid study for chronic pain in women
This trial tests a special band-aid that measures chronic pain. Women with chronic pain or healthy women may join to help researchers learn how this device works.
Chicago, IllinoisAges 18 years+ - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
Chicago, IllinoisAges 18–50 - NCT06591091RecruitingPhase 2
Clemastine for Depression in Older Adults
This study tests if adding clemastine (an allergy medication) to standard antidepressants can improve brain health and boost treatment response in adults over 60 with depression.
Chicago, IllinoisAges 60 years+ - NCT07073521Recruiting
Cognitive therapy for adjusting to vision loss
This study tests new ways to help people adjust to vision loss using thinking and coping strategies. If you are an adult with vision loss and willing to share feedback, this may be a good fit.
Chicago, IllinoisAges 18 years+ - NCT06093282Enrolling by invitation
Community activity program for health and mood
This study tests if a community-based activity program can improve both mood and heart health in people who have limited access to healthcare or live in less-resourced neighborhoods. You may be able to join if you have symptoms of depression and are not very physically active or have a higher body weight.
Chicago, IllinoisAges 18 years+ - NCT06372964RecruitingPhase 3
Lumateperone for pediatric bipolar depression
This study tests a new medication called lumateperone for treating depression in children and teens with bipolar disorder. It aims to see if this drug can help improve mood and daily functioning.
Chicago, IllinoisAges 10–17 - NCT07216326Recruiting
Depression help for Black and Latinx youth
This trial tests a program to help Black and Latinx teens and young adults with depression. It involves in-person sessions to learn coping skills and support.
Chicago, IllinoisAges 15–20 - NCT07276997RecruitingPhase 2
Study of Icalcaprant for major depressive disorder
This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.
Chicago, IllinoisAges 18–65 - NCT06524830RecruitingPhase 2
Testing VLS-01 film for treatment-resistant depression
This trial tests an experimental film placed inside the cheek (VLS-01) against a placebo to see if it helps people whose depression hasn't improved with standard antidepressants. If you have tried at least two antidepressants without success, this study may be an option for you.
Chicago, IllinoisAges 18–65 - NCT06962527Recruiting
Study on how the brain handles uncertainty
This study uses brain imaging to understand how people react to uncertain situations. It may help develop better ways to treat anxiety and related conditions.
Chicago, IllinoisAges 25–60
Hear when a new Depression trial opens near Chicago, IL
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Depression trials in other cities
Where these studies are running near Chicago
Institutions with a site for the recruiting depression studies listed above.
- Northwestern University · 6 studies
- Baber Research Group · 3 studies
- Rush University Medical Center · 3 studies
- University of Illinois · 3 studies
- Advanced Quality Medical Research · 2 studies
- Ann & Robert H. Lurie Children's Hospital of Chicago · 2 studies
- Psychiatric Medicine Associates, LLC · 2 studies
- Revive Research Institute · 2 studies
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in Illinois.
Common questions
- Are there depression clinical trials near Chicago?
- Yes. We're currently tracking 49 recruiting depression studies with a site near Chicago, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near Chicago?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Chicago to take part?
- Not necessarily. These studies have a site near Chicago, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near Chicago regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.