Clinical trials · Chicago, IL
Depression clinical trials in Chicago
We’re tracking 49 recruiting depression studies with a site in or near Chicago — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Chicago
- NCT07073521Recruiting
Cognitive therapy for adjusting to vision loss
This study tests new ways to help people adjust to vision loss using thinking and coping strategies. If you are an adult with vision loss and willing to share feedback, this may be a good fit.
Chicago, IllinoisAges 18 years+ - NCT06093282Enrolling by invitation
Community activity program for health and mood
This study tests if a community-based activity program can improve both mood and heart health in people who have limited access to healthcare or live in less-resourced neighborhoods. You may be able to join if you have symptoms of depression and are not very physically active or have a higher body weight.
Chicago, IllinoisAges 18 years+ - NCT07216326Recruiting
Depression help for Black and Latinx youth
This trial tests a program to help Black and Latinx teens and young adults with depression. It involves in-person sessions to learn coping skills and support.
Chicago, IllinoisAges 15–20 - NCT07276997RecruitingPhase 2
Study of Icalcaprant for major depressive disorder
This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.
Chicago, IllinoisAges 18–65 - NCT06524830RecruitingPhase 2
Testing VLS-01 film for treatment-resistant depression
This trial tests an experimental film placed inside the cheek (VLS-01) against a placebo to see if it helps people whose depression hasn't improved with standard antidepressants. If you have tried at least two antidepressants without success, this study may be an option for you.
Chicago, IllinoisAges 18–65 - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
Chicago, IllinoisAges 18–85 - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Chicago, IllinoisAges 18–85 - NCT07484217RecruitingPhase 3
Testing solriamfetol for depression with daytime sleepiness
This study tests if the drug solriamfetol can help people with major depression who also feel very tired during the day. It aims to improve both mood and daytime sleepiness.
Chicago, IllinoisAges 18–65 - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Chicago, IllinoisAges 18–74 - NCT06962527Recruiting
Study on how the brain handles uncertainty
This study uses brain imaging to understand how people react to uncertain situations. It may help develop better ways to treat anxiety and related conditions.
Chicago, IllinoisAges 25–60 - NCT06636058Recruiting
Digital treatment for weight and mood in adults 50+
This study tests a digital program that helps with weight loss and depression at the same time. It is designed for Black, Hispanic, and other adults over 50 who carry extra weight and feel down.
Chicago, IllinoisAges 50–74 - NCT05051618Recruiting
Exercise program for depression in people with multiple sclerosis
This trial studies whether a structured exercise program can help reduce symptoms of major depressive disorder in people who also have multiple sclerosis. You’ll complete questionnaires, wear an activity sensor, and do exercise testing while being assigned to the study program.
Chicago, IllinoisAges 18–64 - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
Chicago, IllinoisAges 18–74 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Chicago, IllinoisAges 18–64 - NCT07713849Recruiting
Transition care for recent psychosis
This study tests a program to help people recently diagnosed with psychosis (within the last two years) transition from hospital to community care. If you have a psychotic disorder and a caregiver involved in your discharge planning, this could help you.
Chicago, IllinoisAges 18–40 - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
Chicago, IllinoisAges 18–75 - NCT07607613Recruiting
Support for LGBTQ+ Parents with Depression Risk
This study offers group support sessions for LGBTQ+ parents who are pregnant or recently had a baby and are experiencing mild depression or worry about postpartum depression. The goal is to help prevent depression from getting worse and improve emotional well-being during this important life transition.
Chicago, IllinoisAges 18 years+ - NCT07227454RecruitingPhase 3
Esketamine for teens with severe depression and suicidal thoughts
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
Evanston, IllinoisAges 12–17 - NCT07716098RecruitingPhase 3
Esketamine nasal spray for treatment-resistant depression
This study tests esketamine nasal spray versus a placebo in adults with depression that has not improved after trying at least two other antidepressants. It aims to see if the spray can help when standard pills have not worked.
Skokie, IllinoisAges 18 years+ - NCT07076407RecruitingPhase 3
Testing a new antidepressant pill for depression
This study tests an experimental oral pill called azetukalner against a placebo to see if it safely reduces symptoms of major depressive disorder. It is for adults who are currently in a depressive episode lasting 6 weeks to 2 years and have not already tried multiple antidepressants that failed.
Orland Park, IllinoisAges 18–74 - NCT07172516RecruitingPhase 3
Study of azetukalner vs placebo for bipolar depression
This trial tests whether the study drug azetukalner can help reduce depression symptoms in people with bipolar I or II disorder who are currently having a depressive episode. You would be randomly assigned to receive either the drug or a placebo (inactive pill) to see which works better.
Orland Park, IllinoisAges 18–74 - NCT07105111RecruitingPhase 4
Valbenazine for tardive dyskinesia after other treatment
This study tests if valbenazine helps adults with tardive dyskinesia whose symptoms continue even after taking or stopping another similar medication. Tardive dyskinesia involves uncontrollable movements from long-term use of certain mental health drugs.
Naperville, IllinoisAges 18 years+ - NCT07220460RecruitingPhase 2
Study of an oral drug for bipolar depression
This trial tests an experimental pill (ABB-932) for people with bipolar I or II disorder who are currently in a depressive episode. The goal is to see if the drug is safe and helps improve mood.
Elgin, IllinoisAges 18–65 - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
Elgin, IllinoisAges 18–65
Hear when a new Depression trial opens near Chicago, IL
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Depression trials in other cities
Where these studies are running near Chicago
Institutions with a site for the recruiting depression studies listed above.
- Advanced Quality Medical Research · 2 studies
- Northwestern University · 2 studies
- Psychiatric Medicine Associates, LLC · 2 studies
- Rush University Medical Center · 2 studies
- Uptown Research Institute · 2 studies
- Amr Conventions Research
- Ann & Robert H. Lurie Children's Hospital of Chicago
- Autobahn Site #154
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in Illinois.
Common questions
- Are there depression clinical trials near Chicago?
- Yes. We're currently tracking 49 recruiting depression studies with a site near Chicago, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near Chicago?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Chicago to take part?
- Not necessarily. These studies have a site near Chicago, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near Chicago regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.