Clinical trials · Houston, TX
Depression clinical trials in Houston
We’re tracking 53 recruiting depression studies with a site in or near Houston — including Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Houston
- NCT06599099Recruiting
Deep brain stimulation for depression that hasn't responded to other treatments
This trial tests if deep brain stimulation (a surgical implant that sends gentle electrical pulses to a specific area of the brain) can help people with bipolar I disorder who are currently in a severe depressive episode and have not found relief from multiple treatments.
Houston, TexasAges 22–64 - NCT05850689RecruitingPhase 3
Lumateperone add-on for major depression that didn’t improve
This study tests whether adding lumateperone to an antidepressant helps adults with major depressive disorder (MDD) who haven’t improved enough after trying at least two different antidepressants. It may help reduce depressive symptoms more than antidepressants alone.
Houston, TexasAges 18–65 - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Houston, TexasAges 18–85 - NCT03437928Recruiting
Deep brain stimulation for severe, treatment-resistant depression
This trial tests whether deep brain stimulation (DBS, a surgically placed device that sends signals to the brain) can reduce symptoms of long-lasting major depression that has not improved with many treatments. You may be more likely to qualify if your depression has been present for years, has been resistant to multiple medications and therapies, and if you meet specific safety and testing requirements.
Houston, TexasAges 22–70 - NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
Houston, TexasAges 18 years+ - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Houston, TexasAges 18–65 - NCT06923995Recruiting
AI-based depression and anxiety assessment study
This study tests an AI tool that analyzes video and audio recordings to measure depression and anxiety. It is for people starting a new treatment for depression or anxiety and aims to see if the AI can accurately track their progress.
Houston, TexasAges 18–65 - NCT06856057Recruiting
Support for caregivers and kids after injury
This study helps parents and young children cope with stress after a hospital stay for an injury. It tests a program to improve mental health for both caregivers and kids.
Houston, TexasAges 18 years+ - NCT07484217RecruitingPhase 3
Testing solriamfetol for depression with daytime sleepiness
This study tests if the drug solriamfetol can help people with major depression who also feel very tired during the day. It aims to improve both mood and daytime sleepiness.
Houston, TexasAges 18–65 - NCT07060066Recruiting
TMS for depression in schizophrenia
This study tests whether a type of brain stimulation called TMS (transcranial magnetic stimulation) can help with depression in people who have schizophrenia. You would receive TMS sessions targeting areas of the brain linked to mood, and the goal is to see if this improves depression symptoms.
Houston, TexasAges 18–60 - NCT05240352Recruiting
Personalized brain stimulation help for bipolar depression anhedonia
This study looks at using brain scans to better tailor transcranial direct current stimulation (a noninvasive brain stimulation) for people with bipolar depression who feel little pleasure. It aims to see whether matching the stimulation to your brain signals can improve symptoms like anhedonia.
Houston, TexasAges 18–50 - NCT06695767Recruiting
Behavioral therapy for epilepsy and depression in veterans
This trial tests a special therapy program for veterans who have both epilepsy and major depression. It uses talk therapy and text message support to help improve mood and seizure control.
Houston, TexasAges 18 years+ - NCT05220202Recruiting
Program for older vets with pain and depression
This trial tests a non-medicine (non-pharmacologic) home program to help older Veterans manage musculoskeletal pain and depressive symptoms at the same time. You may be assigned to one of two approaches, and you’ll need to be able to take part from home.
Houston, TexasAges 60–99 - NCT06273995Recruiting
Behavioral activation through telehealth for teens with depression
This trial tests if a telehealth program can help teenagers with depression feel better by increasing positive activities. You and a caregiver will attend weekly video sessions for 8 weeks.
Houston, TexasAges 12–18 - NCT06423430Recruiting
Deep brain stimulation for treatment-resistant depression (TRANSCEND)
This trial tests a new brain stimulation treatment (deep brain stimulation, or DBS) for people with hard-to-treat depression. It aims to see if targeting a specific brain area can help when other treatments have failed.
Houston, TexasAges 22–70 - NCT05418894Recruiting
Study brain signals and improve treatment-resistant depression
This trial studies how brain activity relates to feelings and depression, using brain electrodes to measure signals. It’s meant for people with long-lasting, treatment-resistant major depression who may need stimulation while continuing psychiatric care.
Houston, TexasAges 22–70 - NCT06982820Recruiting
Brain training therapy for depression with loss of interest
This trial tests a new type of brain training (self-neuromodulation) to help people with major depression who also have a significant loss of interest or pleasure (anhedonia). If you qualify, you may get a non-invasive treatment that uses real-time brain feedback to improve symptoms.
Houston, TexasAges 22–75 - NCT04080778Recruiting
Magnetic seizure treatment for severe bipolar or hard-to-treat depression
This trial studies whether a seizure-like therapy using magnet stimulation can quickly reduce severe depressive symptoms in people with bipolar depression or treatment-resistant depression. It may help when depression is intense and hasn’t improved enough with at least two antidepressant medicines.
Houston, TexasAges 22–85 - NCT05809115Recruiting
Caregiver-Child Story Visits for Hospitalized Infants
This trial looks at whether a program that strengthens the caregiver-child “story” (how caregivers and young children connect and communicate) can improve early development outcomes. It is offered to caregivers of young hospitalized children at Texas Children’s Hospital.
Houston, TexasAges 18 years+ - NCT05489042Recruiting
Brain scan and rTMS study for suicidal thoughts in opioid users
This study looks at brain connectivity using an MRI scan and then treats some people with rTMS (a non-surgical brain stimulation). It’s designed for adults who use opioids and currently have active suicidal thoughts, to better understand and help those symptoms.
Houston, TexasAges 18–64 - NCT07196501RecruitingPhase 3
Study of a new add-on treatment for depression maintenance
This trial tests a new medication (NBI-1065845) added to your current antidepressant to see if it helps maintain improvement in depression. It is for people whose depression hasn't fully responded to their current oral antidepressant.
Bellaire, TexasAges 18 years+ - NCT06713616RecruitingPhase 3
Esketamine vs. ketamine for hard-to-treat depression
This study compares the effectiveness of esketamine (Spravato) and another similar drug, ketamine, for adults with major depression that has not improved after trying at least two other antidepressants. It aims to find out which treatment works better.
Bellaire, TexasAges 18 years+ - NCT07276997RecruitingPhase 2
Study of Icalcaprant for major depressive disorder
This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.
Bellaire, TexasAges 18–65 - NCT06725277Recruiting
Observing ketamine and Spravato for depression
This study follows people who are already taking or about to start IV ketamine or Spravato® for hard-to-treat depression. Researchers want to learn more about how these treatments work in real life.
Bellaire, TexasAges Any age
Hear when a new Depression trial opens near Houston, TX
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Depression trials in other cities
Where these studies are running near Houston
Institutions with a site for the recruiting depression studies listed above.
- Baylor College of Medicine · 7 studies
- The University of Texas Health Science Center at Houston · 4 studies
- DM Clinical Research · 2 studies
- Houston Center for Advanced Psychiatric Treatment · 2 studies
- Michael E. DeBakey VA Medical Center · 2 studies
- Neurocrine Clinical Site · 2 studies
- Brain Health Consultants and TMS Center
- Clinical Research Site
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in Texas.
Common questions
- Are there depression clinical trials near Houston?
- Yes. We're currently tracking 53 recruiting depression studies with a site near Houston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near Houston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Houston to take part?
- Not necessarily. These studies have a site near Houston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near Houston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.