Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07369557Recruiting
Mindfulness training with TMS for depression
This trial combines mindfulness training with accelerated TMS therapy for depression. It tests if adding mindfulness helps improve treatment outcomes.
Charleston, South CarolinaAges 18–80 - NCT07363980Enrolling by invitation
Heart CT Study for Rheumatoid Arthritis Patients
This study uses a special heart CT scan to look for early signs of heart disease in people with rheumatoid arthritis. It may help find problems before symptoms start.
AarhusAges 50–75 - NCT07369102RecruitingPhase 4
Esketamine with or without talk therapy for tough depression
This trial tests if adding a type of talk therapy called integration therapy helps esketamine work better for people with depression that hasn't improved with other treatments. You'll receive esketamine, and some people also get guided sessions to reflect on their experiences.
San JuanAges 21–65 - NCT05441969Recruiting
Brain stimulation study for major depression symptoms
This trial studies a way to change how excitable the brain is (through in-person brain stimulation) in people with major depression. It may help understand new treatments or symptom patterns that could be useful for major depression.
LisbonAges 18–65 - NCT06719427RecruitingPhase 1
Brain waves study for depression treatment with rTMS
This study looks at brain wave patterns in people with depression who are receiving a type of brain stimulation called rTMS. It aims to understand how the brain changes during recovery, which may help improve future treatments.
North York, OntarioAges 18–80 - NCT07349706Recruiting
Breathing exercise for dementia risk reduction
This trial tests a simple breathing exercise done for about 5–10 minutes each day for 8 weeks. It aims to see if this exercise can reduce your risk of dementia. If you are between 60 and 80 years old and have at least one risk factor for dementia, this study may be a fit for you.
Tallahassee, FloridaAges 60–80 - NCT07349550Recruiting
Cognitive function, mental health, and work
This trial explores how thinking skills (like memory and focus) relate to common mental health challenges and work life. It aims to find better ways to support people with depression or anxiety who are at risk of needing sick leave.
OsloAges 18–65 - NCT07334561Recruiting
Brain stimulation for depression and pain
This study tests a non-invasive brain stimulation treatment (transcranial electrical stimulation) for people who have both depression and chronic pain. It aims to see if this treatment can help improve mood and reduce pain.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07331987Recruiting
Probiotics for mild to moderate anxiety or depression study
This trial tests if probiotics can help reduce symptoms of mild to moderate anxiety or depression. It is for people aged 18–60 who are not currently taking most anxiety or depression medications and who have not used them in the last 2 weeks (except for escitalopram).
Guangzhou, GuangdongAges 18–60 - NCT07328373Recruiting
Depression Relapse Predictors Study
This trial looks at brain and genetic markers to understand why depression returns. It is for people with major depression who are not currently taking medication.
IstanbulAges 18–65 - NCT07333027Recruiting
Loneliness in depression treatment study
This study looks at how loneliness affects people hospitalized for depression. It may help researchers understand how to better support recovery.
Erlangen, BavariaAges 18 years+ - NCT06728280Recruiting
DTMS for teens with depression: safety and effectiveness
This trial tests if a new type of brain stimulation called DTMS can safely help adolescents with major depression. It may be an option if you have tried other treatments and are looking for a non-medication approach.
Taiyuan, ShanxiAges 11–23 - NCT06698107Recruiting
Childbirth education for teen mothers to prevent depression
This program tests a special childbirth education class designed to help first-time teen mothers feel more confident and prepared, with the goal of reducing the chance of depression after the baby is born.
Bahir Dar, AmharaAges 13–19 - NCT06392867Recruiting
Brain stimulation for stubborn depression: intensity study
This study tests a type of brain stimulation called TMS (transcranial magnetic stimulation) for people with depression that hasn't improved with at least two antidepressants. Researchers want to see if a faster version of TMS (theta-burst stimulation) helps reduce depression symptoms.
Hong KongAges 18–70 - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
Bentonville, ArkansasAges 18–75 - NCT07302165Enrolling by invitation
Online tool to screen and prevent postpartum depression in parents-to-be
This trial tests a digital tool to find and help parents at risk for depression after childbirth. You may qualify if you have certain thinking patterns or risk factors during pregnancy.
CopenhagenAges 18 years+ - NCT07299903Recruiting
Sleep hygiene education study for menopausal women
This study tests if an online sleep hygiene program can improve sleep quality and reduce depression in menopausal women. It is designed for those with low sleep quality and access to a smartphone or computer.
AnkaraAges 45–60 - NCT07304219Enrolling by invitation
Physical activity program for depression and anxiety in teens
This study tests whether a physical activity program can help young people with depression or anxiety feel better. If you are already receiving care at Haukeland's child and adolescent clinic, you might be able to join a group program designed to boost your mood and reduce anxiety.
Bergen, VestlandAges 8–18 - NCT07294274Recruiting
Predicting depression risk after a stroke
This study creates a tool to predict if someone might develop depression after an ischemic stroke. It aims to help doctors identify and support patients who are at higher risk.
ChongqingAges Any age - NCT07292649Recruiting
Labor pain relief and postpartum depression risk
This study looks at how your expectations about pain relief during labor might affect your mood after giving birth. Researchers will follow you after delivery to see if there is a link between your hopes for pain management and the risk of postpartum depression.
Padova, VenetoAges 18 years+ - NCT07287878Recruiting
Brain stimulation to improve social reward in depression
This trial tests a new type of brain stimulation called temporal interference stimulation to see if it can improve how people with depression experience social rewards. You may be eligible if you have depression with certain features like increased appetite, weight gain, or feeling very sensitive to rejection, and you are between 16 and 60 years old.
Shanghai, ChinaAges 16–65 - NCT07293806Recruiting
Dance therapy for teens with depression
This study tests whether dance-movement therapy (moving with a therapist to express feelings) can help teens with moderate to severe depression feel better. It is for adolescents who are not experiencing other severe mental health conditions like psychosis or a critical substance use problem.
HelsinkiAges 13–17 - NCT07279311Enrolling by invitation
Virtual reality for depression during high-risk pregnancy
This study tests if virtual reality (VR) exercises can help reduce depression symptoms in pregnant people who must stay in the hospital for at least 3 weeks due to complications. If you are feeling down and are able to use VR, this treatment might offer a new way to feel better.
Palo Alto, CaliforniaAges 18 years+ - NCT07284446Recruiting
Depression, memory, and outcomes in heart failure patients
This study looks at how depression and memory problems affect recovery in people hospitalized with worsening chronic heart failure. It aims to find better ways to support patients during their hospital stay.
KaunasAges 18–85
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.