Clinical trials
Depressive Symptoms clinical trials
Below are recruiting depressive symptoms clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06294184Recruiting
Brain stimulation for mild depression in young people
This trial tests a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) to see if it can help young people with mild depression symptoms. It is designed for those who have some depressive feelings but do not yet meet the full criteria for major depression.
Guangzhou, GuangdongAges 12–25 - NCT07305415Recruiting
Emotion support program for dementia caregivers
This trial tests a program designed to help informal caregivers of people with dementia manage their expressed emotions. If you care for a loved one with dementia and feel emotionally stressed, this program may help you regulate your feelings and improve your caregiving experience.
Hong KongAges 18–100 - NCT05836090Recruiting
Family Spirit Strengths program for pregnant people and caregivers
This trial tests a family-focused program to support mental health and reduce risks related to substance use. It may help you if you’re pregnant or caring for a child 24 months or younger and you’re experiencing depression/anxiety and/or substance-use risk.
Chinle, ArizonaAges 14 years+ - NCT06778096Recruiting
Online therapy for anxiety and depression in new moms
This trial tests an online therapy program for new moms who feel anxious or depressed. It uses cognitive-behavioral therapy (CBT) through a computer or tablet to help you manage your mood.
Châteauguay, QuebecAges 18 years+ - NCT07391540Recruiting
Internet therapy for financial stress
This trial tests an internet-based cognitive behavioral therapy (ICBT) program for people feeling mild to moderate psychological symptoms because of money worries. It aims to see if online treatment can help reduce these symptoms.
Linköping, Östergötland CountyAges 18 years+ - NCT07469462Recruiting
High-dose vitamin B6 for depression and anxiety
This study tests whether high doses of vitamin B6 can help reduce symptoms of anxiety and depression. If you have mild to moderate anxiety or depression, you may be able to participate.
Reading, EnglandAges 18–41 - NCT05405803Recruiting
Web app to improve depressive symptoms in midlife Korean American women
This study tests a web-based (internet) program to help reduce depressive symptoms in midlife Korean American women. You may qualify if you’ve had mild to moderate low mood recently and can use the internet.
Austin, TexasAges 40–60 - NCT07639359RecruitingPhase 2
Ketamine for depression in intensive care patients
This study tests whether low-dose ketamine infusions can reduce depressive symptoms in patients staying in the intensive care unit for at least 6 days. Ketamine is a medication that may work differently than standard antidepressants and could provide faster relief.
Jacksonville, FloridaAges 18–99 - NCT06658041Recruiting
A step-by-step program for mild to moderate depression
This trial tests a structured support program for adults with mild to moderate depression. It uses a team-based approach in primary care to help you feel better step by step.
Hong Kong, HONG KONGAges 45–59 - NCT07398469Recruiting
Long-term study of zuranolone for postpartum depression symptoms
This study checks how people with postpartum depression feel over time after starting zuranolone. It uses simple questionnaires to track changes in symptoms.
Cambridge, MassachusettsAges 18 years+ - NCT07652775Recruiting
Brain stimulation and exercise for memory and mood
This study tests whether combining rTMS (a non‑invasive brain stimulation) with aerobic exercise can improve memory, thinking, and mood in older adults who have mild memory problems and depression. It may offer a safe, drug‑free way to help both brain health and emotional well‑being.
Taipei, Taipei CityAges 65–90 - NCT06807801Recruiting
Baby swimming for postpartum depression and bonding
This study looks at whether taking your baby for swimming sessions can help with feelings of depression and strengthen the bond between you and your baby after childbirth.
UppsalaAges 18 years+ - NCT06480019Recruiting
Group talk therapy for depression in young adults
This study tests if a group therapy program led by non-professionals can help reduce depressive symptoms in young adults aged 18-24 who live, work, or study in Porto Alegre, Brazil. You may benefit if you have mild to moderate depression but no risk of suicide.
Porto Alegre, Rio Grande do SulAges 18–24 - NCT06390462Recruiting
Counseling for teens in school-based primary care
This study tests a brief counseling approach called Interpersonal Counseling for Adolescents (IPC-A) in school settings. It aims to help teens with emotional or social challenges before they become more serious, and it's designed for those who aren't already in mental health treatment.
HämeenlinnaAges 13–16 - NCT07462013Recruiting
Lifestyle changes to prevent memory loss with depression
This study tests if healthy lifestyle changes can protect memory and thinking skills in people with depression who have no or mild memory problems.
Taichung, TaichungAges 50–80 - NCT07218263Recruiting
AI app to detect fatigue and depression
This trial studies whether an AI-powered app can help detect signs of fatigue and depression. It may be a good fit if you are an adult who can speak English and are willing to try the app.
Indianapolis, IndianaAges 18–99 - NCT07227454RecruitingPhase 3
Esketamine for teens with severe depression and suicidal thoughts
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
Birmingham, AlabamaAges 12–17 - NCT06350201Recruiting
Online CBT Based on Symptom Groups
This study uses a computer program to group symptoms and then offers an online cognitive behavioral therapy (CBT) program. It aims to help people who feel depressed or anxious by tailoring treatment based on their specific symptom patterns.
WuhanAges 18–64 - NCT07384273Recruiting
Online therapy for postpartum depression symptoms
This trial tests an internet-based therapy program (iCARE) to help new mothers manage symptoms of postpartum depression. It may be a good fit if you gave birth within the last 6 months and have been feeling down or depressed.
OdenseAges 18 years+ - NCT07653113Enrolling by invitation
Music therapy for depression and anxiety in men
This trial tests whether a special type of music therapy, based on Chinese five-element theory, can help men with depression and anxiety. It is designed for male inpatients who have not taken antidepressants recently.
Shanxi, ShanxiAges 18–44 - NCT06467695Recruiting
Low voltage brain stimulation for depression in Parkinson's
This study tests whether a gentle, low-voltage electrical stimulation (tDCS) can help improve depression in people with Parkinson's disease. It involves coming to the lab for sessions where a small device sends a mild current to your brain, and you'll also have an EEG (a non-invasive brain wave recording).
Mobile, AlabamaAges 19–65 - NCT06547489RecruitingPhase 2
Testing zelquistinel for major depression
This study tests whether zelquistinel, an investigational drug, can reduce symptoms of major depressive disorder (a type of clinical depression). It is for people who are currently experiencing a moderate to severe depressive episode and are not taking other antidepressants.
Birmingham, AlabamaAges 18–64 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Phoenix, ArizonaAges 18–64 - NCT05921201Recruiting
RRE program to prevent depression in Chinese American teens
This trial tests an education and skills program (Relax, Reflect, and Empower, or RRE) designed to help prevent depression in Chinese American teens. It may help by teaching coping strategies before symptoms become more serious.
Boston, MassachusettsAges 14–18
Hear when a new Depressive Symptoms trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for depressive symptoms?
- Yes. Clin2 currently lists 194 recruiting depressive symptoms studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive symptoms trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive symptoms trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.