Clinical trials
Depressive Symptoms clinical trials
Below are recruiting depressive symptoms clinical trials, each written for real people, not researchers. We’re tracking 182 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06778096Recruiting
Online therapy for anxiety and depression in new moms
This trial tests an online therapy program for new moms who feel anxious or depressed. It uses cognitive-behavioral therapy (CBT) through a computer or tablet to help you manage your mood.
Châteauguay, QuebecAges 18 years+ - NCT07391540Recruiting
Internet therapy for financial stress
This trial tests an internet-based cognitive behavioral therapy (ICBT) program for people feeling mild to moderate psychological symptoms because of money worries. It aims to see if online treatment can help reduce these symptoms.
Linköping, Östergötland CountyAges 18 years+ - NCT05405803Recruiting
Web app to improve depressive symptoms in midlife Korean American women
This study tests a web-based (internet) program to help reduce depressive symptoms in midlife Korean American women. You may qualify if you’ve had mild to moderate low mood recently and can use the internet.
Austin, TexasAges 40–60 - NCT07652775Recruiting
Brain stimulation and exercise for memory and mood
This study tests whether combining rTMS (a non‑invasive brain stimulation) with aerobic exercise can improve memory, thinking, and mood in older adults who have mild memory problems and depression. It may offer a safe, drug‑free way to help both brain health and emotional well‑being.
Taipei, Taipei CityAges 65–90 - NCT07398469Recruiting
Long-term study of zuranolone for postpartum depression symptoms
This study checks how people with postpartum depression feel over time after starting zuranolone. It uses simple questionnaires to track changes in symptoms.
Cambridge, MassachusettsAges 18 years+ - NCT06658041Recruiting
A step-by-step program for mild to moderate depression
This trial tests a structured support program for adults with mild to moderate depression. It uses a team-based approach in primary care to help you feel better step by step.
Hong Kong, HONG KONGAges 45–59 - NCT06909669Recruiting
Brief therapy for anxiety, depression, or physical symptoms
This study tests short-term psychological treatments to help people with mild or moderate emotional symptoms like anxiety, depression, or physical complaints (such as pain or fatigue) that may be linked to stress. The goal is to see if these brief therapies can improve how you feel.
Córdoba, CórdobaAges 18 years+ - NCT06807801Recruiting
Baby swimming for postpartum depression and bonding
This study looks at whether taking your baby for swimming sessions can help with feelings of depression and strengthen the bond between you and your baby after childbirth.
UppsalaAges 18 years+ - NCT07462013Recruiting
Lifestyle changes to prevent memory loss with depression
This study tests if healthy lifestyle changes can protect memory and thinking skills in people with depression who have no or mild memory problems.
Taichung, TaichungAges 50–80 - NCT06390462Recruiting
Counseling for teens in school-based primary care
This study tests a brief counseling approach called Interpersonal Counseling for Adolescents (IPC-A) in school settings. It aims to help teens with emotional or social challenges before they become more serious, and it's designed for those who aren't already in mental health treatment.
HämeenlinnaAges 13–16 - NCT06480019Recruiting
Group talk therapy for depression in young adults
This study tests if a group therapy program led by non-professionals can help reduce depressive symptoms in young adults aged 18-24 who live, work, or study in Porto Alegre, Brazil. You may benefit if you have mild to moderate depression but no risk of suicide.
Porto Alegre, Rio Grande do SulAges 18–24 - NCT07384273Recruiting
Online therapy for postpartum depression symptoms
This trial tests an internet-based therapy program (iCARE) to help new mothers manage symptoms of postpartum depression. It may be a good fit if you gave birth within the last 6 months and have been feeling down or depressed.
OdenseAges 18 years+ - NCT07227454RecruitingPhase 3
Esketamine for teens with severe depression and suicidal thoughts
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
Birmingham, AlabamaAges 12–17 - NCT07653113Enrolling by invitation
Music therapy for depression and anxiety in men
This trial tests whether a special type of music therapy, based on Chinese five-element theory, can help men with depression and anxiety. It is designed for male inpatients who have not taken antidepressants recently.
Shanxi, ShanxiAges 18–44 - NCT06467695Recruiting
Low voltage brain stimulation for depression in Parkinson's
This study tests whether a gentle, low-voltage electrical stimulation (tDCS) can help improve depression in people with Parkinson's disease. It involves coming to the lab for sessions where a small device sends a mild current to your brain, and you'll also have an EEG (a non-invasive brain wave recording).
Mobile, AlabamaAges 19–65 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Phoenix, ArizonaAges 18–64 - NCT06547489RecruitingPhase 2
Testing zelquistinel for major depression
This study tests whether zelquistinel, an investigational drug, can reduce symptoms of major depressive disorder (a type of clinical depression). It is for people who are currently experiencing a moderate to severe depressive episode and are not taking other antidepressants.
Birmingham, AlabamaAges 18–64 - NCT06589544Recruiting
Virtual reality and brain stimulation for depression in cancer patients
This trial tests whether combining virtual reality therapy with transcranial magnetic stimulation (a non-invasive brain treatment) can help reduce depression in people who have had cancer in the last 5 years. It aims to improve mood without using medication.
Ferrara, FEAges 18–100 - NCT05921201Recruiting
RRE program to prevent depression in Chinese American teens
This trial tests an education and skills program (Relax, Reflect, and Empower, or RRE) designed to help prevent depression in Chinese American teens. It may help by teaching coping strategies before symptoms become more serious.
Boston, MassachusettsAges 14–18 - NCT07569133Enrolling by invitation
Brain stimulation for depression in Parkinson's disease
This study tests whether a non-invasive brain stimulation treatment called repetitive transcranial magnetic stimulation (rTMS) can help improve depressive symptoms in people with Parkinson's disease. If you have Parkinson's and feel depressed, this treatment might be a new option for you.
Daegu, Buk-guAges 40–90 - NCT06203899Recruiting
Depression and suicide prevention for teens in special schools
This study tests a program to prevent depression and suicide in teens at special schools. It helps if you've had some symptoms but aren't already getting treatment.
Boekel, Noordoost BrabantAges 12–18 - NCT07474363Recruiting
Depression differences between men and women
This study looks at how depression affects men and women differently, including symptoms, strength to cope (resilience), and feelings of stigma. It aims to understand these differences to improve treatment.
Eskişehir, EskişehirAges 18–65 - NCT06078007Recruiting
App for depression and anxiety in college students
This trial tests if a guided mobile app can help college students with mild to moderate depression or anxiety. You might benefit if you are not currently receiving mental health treatment and have a smartphone.
Palma de Mallorca, Balearic IslandsAges 18 years+ - NCT07007247Enrolling by invitation
Digital aftercare for teens with depression after hospital discharge
This pilot study tests a digital program to support adolescents aged 12–17 with depression after they leave the hospital. It aims to help prevent relapse and improve well-being using a smartphone, tablet, or computer.
HamburgAges 12–17
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Common questions
- Are there clinical trials for depressive symptoms?
- Yes. Clin2 currently lists 182 recruiting depressive symptoms studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive symptoms trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive symptoms trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.