Clinical trials
Depressive Symptoms clinical trials
Below are recruiting depressive symptoms clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05426967Recruiting
Brain stimulation for depression after mild traumatic brain injury
This trial studies a noninvasive brain treatment (rTMS) to reduce depression symptoms in people with past mild traumatic brain injury from military service. It may help by changing brain activity, while also requiring stable mental health care and regular follow-up.
Palo Alto, CaliforniaAges 18–55 - NCT06223880RecruitingPhase 4
AXS-05 vs Bupropion to prevent depression relapse
This study tests whether a new drug called AXS-05 can prevent depression from coming back, compared to an older drug called bupropion. If you have major depression and are at risk of relapse, this trial may help you stay well.
Bellflower, CaliforniaAges 18–65 - NCT06582784Recruiting
Using a phone app to help cancer survivors with depression
This study tests a mobile app to help cancer survivors who are feeling depressed. If you have a smartphone and are willing to use an app for mood support, you may be able to join.
Charleston, South CarolinaAges 18 years+ - NCT06358495Recruiting
Sleep improvement to prevent depression and anxiety in teens
This study tests if improving sleep can help prevent depression and anxiety in teens who are at higher risk because a parent has had depression or anxiety. It's for teens who have trouble sleeping but don't have a history of depression or anxiety themselves.
Calgary, AlbertaAges 12–18 - NCT07317271Recruiting
Virtual reality for burn symptoms
This trial tests a virtual reality program to help with symptoms like pain, trouble sleeping, and itching after a burn injury. You can join from home using your own device.
Baltimore, MarylandAges 18 years+ - NCT05280028Recruiting
Hormone treatment for overactive bladder and mood symptoms
This trial studies whether hormone treatment can improve overactive bladder symptoms, sexual well-being, mood (depressive symptoms), and body “autonomic” function (automatic body functions like heart rate and sweating) in post-menopausal women. It may help by targeting menopausal changes that can affect these symptoms.
Banqiao District, New TaipeiAges 20 years+ - NCT06626425Recruiting
Well-being training for teens with depression
This study tests a 4-week well-being training program to see if it helps teens feel better and manage depression. You would use a smartphone app and answer surveys to track your mood and well-being.
Madison, WisconsinAges 14–19 - NCT05699525Recruiting
Personalized app for cognitive behavioral therapy for young adults
This trial tests a mobile app that delivers personalized cognitive behavioral therapy (a structured talk-therapy approach that helps change unhelpful thoughts and behaviors). It may help reduce symptoms of anxiety, depression, or bipolar disorder for people who fit the study’s timing and safety requirements.
New York, New YorkAges 18–25 - NCT05892965Recruiting
Instant-message online therapy for early post-stroke depression
This study tests whether brief online cognitive behavioral therapy (CBT) delivered through instant messages can reduce depression symptoms after a stroke. It may help if your depression started after your stroke and you have mild to moderately severe symptoms.
Hong KongAges 18 years+ - NCT06786936Recruiting
Study of IL-17 in depression with psoriasis
This study explores whether a protein called IL-17 might link skin/joint inflammation with depressive symptoms. If you have psoriasis or psoriatic arthritis and are starting a specific biologic (secukinumab, bimekizumab, or ixekizumab), this could help understand how treatment affects your mood.
Glasgow, ScotlandAges 18–74 - NCT06828276Recruiting
Online therapy for Farsi and Dari speaking young migrants
This study tests if a culturally adapted online therapy program helps reduce anxiety and depression in young Farsi or Dari speaking migrants. You would use your computer or phone for 6 to 10 weeks at home.
StockholmAges 15–29 - NCT07055906Recruiting
Video coaching to help Latino families talk about race
This study tests a video-based coaching program to help Latino parents and their 10–14-year-old children talk about race and ethnic background. Families will be recorded having a conversation, then get feedback to strengthen their communication.
Harrisburg, PennsylvaniaAges 10–14 - NCT07208851Recruiting
Booster session for mental health support in the Bahamas
This trial tests a short booster session for a mental health support program called Problem Management Plus. It may help adults in the Bahamas who are struggling with daily life but don't have severe mental health conditions.
Freeport, Grand BahamaAges 18 years+ - NCT07299903Recruiting
Sleep hygiene education study for menopausal women
This study tests if an online sleep hygiene program can improve sleep quality and reduce depression in menopausal women. It is designed for those with low sleep quality and access to a smartphone or computer.
AnkaraAges 45–60 - NCT07375485Enrolling by invitation
Occupational therapy for brain injury recovery at home
This trial explores how occupational therapy can help people with brain injuries stay engaged in daily life. Researchers want to learn from therapists working in home or community settings to improve care.
Denver, ColoradoAges 18 years+ - NCT07654179Recruiting
Metformin for depression with obesity: a genetic study
This trial tests if adding metformin to antidepressants helps people who have both depression and obesity. It also looks at genetic factors that might affect treatment response.
Rawalpindi, Punjab ProvinceAges Any age - NCT06358898Recruiting
Digital sleep and mood program for teens with depression
This trial tests a digital program that uses a smartphone app to help teens with both insomnia and depression. It combines a mood tracker with cognitive behavioral therapy for insomnia (CBT-I) to improve sleep and mood.
Shatin, New TerritoriesAges 12–18 - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Birmingham, AlabamaAges 18–74 - NCT07216326Recruiting
Depression help for Black and Latinx youth
This trial tests a program to help Black and Latinx teens and young adults with depression. It involves in-person sessions to learn coping skills and support.
Chicago, IllinoisAges 15–20 - NCT07638553RecruitingPhase 3
Psilocybin to prevent alcohol relapse with depression
This study tests whether psilocybin (a psychedelic compound) can help people with severe alcohol use disorder stay sober longer, especially if they also have depression. Participants receive guided psilocybin sessions alongside counseling to reduce the risk of returning to heavy drinking.
BayonneAges 18 years+ - NCT07041073Recruiting
Brain training for emotion control in depression
This trial tests if a non-invasive brain training technique called neurofeedback can help people with major depression improve how they manage emotions. You participate by doing computer tasks while your brain activity is measured and shown back to you, teaching you to regulate your emotions better.
Sabadell, Barcelona, CataluñaAges 18–65 - NCT07136714RecruitingPhase 4
Semaglutide for depression in people with overweight
This study tests whether a weekly injection of semaglutide (a medication used for weight loss and diabetes) can help reduce symptoms of depression in people who have major depressive disorder and are overweight or obese.
Hillerød, DenmarkAges 18–65 - NCT05523817Recruiting
Brain scan targeting to improve specific depression symptoms
This study uses brain-signal targeting (likely with MRI) to see whether it can improve certain symptoms of depression. You may be able to join if you’re 18–65 and currently have a depressive episode, and if you can safely complete the scan.
Boston, MassachusettsAges 18–65 - NCT06363981Recruiting
Brain stimulation for depression, sleep and memory problems
This study tests a non-invasive brain stimulation treatment (called rTMS) to help with depression, sleep problems, and memory or concentration issues. It's designed for people with moderate to severe depression who also have trouble sleeping and thinking clearly.
KrakowAges 18–65
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Common questions
- Are there clinical trials for depressive symptoms?
- Yes. Clin2 currently lists 194 recruiting depressive symptoms studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive symptoms trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive symptoms trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.