Clinical trials
Diffuse Glioma clinical trials
Below are recruiting diffuse glioma clinical trials, each written for real people, not researchers. We’re tracking 60 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06914479RecruitingPhase 1
Gene therapy and valacyclovir for recurrent brain tumors in young people
This trial tests a new gene therapy that uses two special viruses and an oral antiviral drug (valacyclovir) to treat brain tumors that have come back in children and young adults. The therapy is given right after surgery to remove the tumor, with the goal of helping your immune system fight the cancer.
Ann Arbor, MichiganAges 3–39 - NCT05099003RecruitingPhase 1/Phase 2
Selinexor plus radiation for newly diagnosed brain tumors
This trial studies whether adding selinexor to standard radiation can improve outcomes for children and young teens with certain newly diagnosed high-grade brain tumors (including DIPG). It’s designed for specific tumor types and genetic markers, and people must be able to start treatment soon after diagnosis.
Birmingham, AlabamaAges 1–21 - NCT06465199RecruitingPhase 1/Phase 2
Eflornithine and AMXT 1501 for Advanced Childhood Cancers
This trial tests a combination of two drugs (eflornithine and AMXT 1501) for children and young adults with certain types of cancer that have relapsed or not responded to standard treatment, or for a specific brain tumor (DIPG) at diagnosis. The goal is to see if this drug pair is safe and effective.
Birmingham, AlabamaAges Up to 26 years - NCT02509442Recruiting
Testing brain responses during awake brain surgery
This trial measures how the brain reacts to small electrical stimulation during an awake surgery for a specific type of brain tumor. It may help surgeons better plan and improve care for people having their first surgery for this tumor type.
MontpellierAges 30–50 - NCT04250064RecruitingPhase 2
Low-dose bevacizumab with standard radiation for DIPG
This Phase 2 study tests whether adding low-dose bevacizumab (a medicine that affects blood vessel growth) to standard radiation can help children newly diagnosed with DIPG. It’s meant for certain children with a specific type of brain tumor that has not spread.
Mumbai, MaharashtraAges 3–18 - NCT06221553RecruitingPhase 1
New CAR T-cell treatment for DIPG brain tumor
This trial tests a new type of immunotherapy called B7H3 IL-7Ra CAR T-cells for children with DIPG, a tough-to-treat brain tumor. The treatment is given directly into the fluid around the brain using a special catheter, and the goal is to see if it's safe and if it can help fight the tumor.
Bangkok, PathumwanAges 1–18 - NCT04837547RecruitingPhase 1
Personalized cell therapy for childhood cancer
This trial tests a new, personalized cell therapy for children with high-risk neuroblastoma or DIPG (a type of brain tumor) that has come back or is hard to treat. It uses the patient's own tumor to create a treatment that might work better for them.
Gainesville, FloridaAges 1–30 - NCT07584499RecruitingPhase 1
New drug test for children with EGFR-positive solid tumors
This study tests a new cancer drug called Becotatug Vedotin in children ages 2–18 with certain types of solid tumors (cancers that form in organs or tissues) that have an EGFR protein. The drug is designed to find tumors with this protein and attack cancer cells while sparing healthy ones.
Guangzhou, GuangdongAges 2–18 - NCT06794736Recruiting
Study on metabolic profiles in lower-grade gliomas
This study looks at how lower-grade gliomas (a type of slow-growing brain tumor) use energy. It may help doctors better understand the tumor and choose the best treatment for you.
Bari, ApuliaAges 18 years+ - NCT07468136RecruitingPhase 1/Phase 2
Retifanlimab with or without DFMO for progressive high-grade gliomas
This study tests a combination of two drugs—retifanlimab (an immunotherapy that helps your immune system fight cancer) and DFMO (a medicine that may stop tumor growth)—in people with high-grade brain tumors that are growing. Participants will receive these treatments before and after their planned surgery.
Rochester, MinnesotaAges 18 years+ - NCT04623931RecruitingPhase 2
Chemo and radiation for IDH-wildtype glioma
This Phase 2 study tests a combination of chemotherapy and radiation after surgery for certain brain tumors that are “IDH wildtype.” It aims to control the tumor and improve outcomes for people with specific types of glioma or glioblastoma.
Houston, TexasAges 18 years+ - NCT07717827Recruiting
Brain tumor surgery guided by brain wiring maps
This trial uses advanced brain scans to create a detailed map of your brain's wiring before surgery. This helps surgeons remove more tumor safely while protecting important areas that control movement, language, and vision.
Palermo, PAAges 18 years+
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Common questions
- Are there clinical trials for diffuse glioma?
- Yes. Clin2 currently lists 60 recruiting diffuse glioma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a diffuse glioma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a diffuse glioma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.