Clinical trials · Cincinnati, OH
Down Syndrome clinical trials in Cincinnati
We’re tracking 58 recruiting down syndrome studies with a site in or near Cincinnati — including Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Cincinnati
- NCT05701917Recruiting
Clot-busting device versus blood thinners for leg clot
This study compares a clot-removal device (ClotTriever) plus standard care versus standard blood thinners alone for a deep vein clot in the leg. It aims to see which approach better improves leg symptoms and outcomes.
Cincinnati, OhioAges 18 years+ - NCT06247787RecruitingPhase 1
Imetelstat plus chemo for relapsed leukemia in kids
This trial tests a new drug called imetelstat combined with two chemotherapy drugs (fludarabine and cytarabine) for children and teens with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or juvenile myelomonocytic leukemia (JMML) that has come back or not responded to treatment. The goal is to find the safest dose of imetelstat and see if it helps control the cancer.
Cincinnati, OhioAges 1–18 - NCT06227780Recruiting
Sound therapy for thinking and sensory issues in kids with developmental disorders
This trial tests whether special sound patterns played through headphones can help improve thinking and reduce sensitivity to noise in children with Fragile X syndrome or autism. The study uses a short daily listening program over several weeks to see if it makes a difference.
Cincinnati, OhioAges 5–10 - NCT06512883RecruitingPhase 3
Testing benralizumab in children with eosinophil diseases
This trial tests a medicine called benralizumab for children with specific eosinophil-driven diseases (EGPA or HES). It aims to see if the drug can help control these conditions.
Cincinnati, OhioAges 6–17 - NCT05957549Recruiting
Tracking early sound perception in young children
This study uses special brain-monitoring tools (fNIRS and EEG) to look at how preschool-aged children process sounds. It may help researchers understand early sound perception differences, especially in children with Fragile X Syndrome.
Cincinnati, OhioAges 2–4 - NCT06043440RecruitingPhase 2
Oxygen therapy for sleep apnea in Down syndrome
This study tests whether oxygen therapy can help children with Down syndrome who have sleep apnea. It compares oxygen treatment to no treatment to see if it improves breathing during sleep and thinking skills.
Cincinnati, OhioAges 5–18 - NCT06914609RecruitingPhase 3
Study of ION582 for people with Angelman syndrome
This trial tests a new medicine called ION582 for people with Angelman syndrome. It aims to see if it can help with symptoms and is given as a lumbar puncture (spinal tap). You may be able to join if you have a genetic diagnosis of Angelman syndrome and are between 2 and 50 years old.
Cincinnati, OhioAges 2–50 - NCT04462770RecruitingPhase 3
Clemizole trial for children and adults with Dravet syndrome
This Phase 3 study tests EPX-100 (clemizole) to help reduce seizures in people with Dravet syndrome whose seizures are not fully controlled by current anti-seizure medicines. You may consider this study if your Dravet diagnosis is confirmed and your medical situation fits the specific rules about medicines and seizure causes.
Cincinnati, OhioAges 2 years+ - NCT06991400Recruiting
A study of a new surgical approach for TTTS and TAPS
This trial tests a new surgical technique for twin-to-twin transfusion syndrome (TTTS) or twin anemia-polycythemia sequence (TAPS). It places a stitch through the amniotic sac during surgery to see if it helps. The study is for pregnant people between 18 and 23 weeks with healthy cervical length and a safe access point for surgery.
Cincinnati, OhioAges 18 years+ - NCT07593391RecruitingPhase 3
NNZ-2591 Treatment for Children with Phelan-McDermid Syndrome
This study tests whether a medication called NNZ-2591 can help children with Phelan-McDermid syndrome, a rare genetic condition that affects brain development and learning. Researchers want to see if this drug can improve how children with this condition develop and learn.
Cincinnati, OhioAges 3–12 - NCT07742735RecruitingPhase 3
Study of apraglutide for short bowel syndrome with intestinal failure
This study tests a new medicine called apraglutide, given as a shot, to see if it can help adults with short bowel syndrome and intestinal failure reduce their need for intravenous nutrition (parenteral support). The study compares apraglutide to a placebo (a shot with no medicine) to check if it is safe and effective.
Cincinnati, OhioAges 18 years+ - NCT01186913Enrolling by invitation
Natural history study for severe combined immune deficiency (SCID)
This study follows children and adults with SCID and related immune disorders to understand how the illness behaves over time. It also helps researchers learn which testing results and genetic types of SCID match different treatment plans.
Cincinnati, OhioAges Any age - NCT02143830RecruitingPhase 2
Stem cell transplant chemotherapy for Fanconi anemia
This Phase 2 study tests a stem cell transplant approach using adjusted chemotherapy doses for people with Fanconi anemia. It may help replace damaged bone marrow and treat blood problems like severe aplastic anemia, MDS, or leukemia.
Cincinnati, OhioAges 3 months+ - NCT06679855RecruitingPhase 3
Milrinone to prevent heart problems after PDA closure
This trial tests if giving milrinone before surgery to close a common heart vessel (PDA) can prevent heart issues in premature babies. It may help very premature infants who need surgery for a large PDA.
Cincinnati, OhioAges Up to 3 months - NCT05334368RecruitingPhase 3
Depemokimab for hypereosinophilic syndrome with frequent flares
This trial studies depemokimab, a medicine meant to reduce flares in people with hypereosinophilic syndrome (HES). It also checks how safe the treatment is and how well it works over time.
Cincinnati, OhioAges 18 years+ - NCT06066502RecruitingPhase 3
Precision ventilation for ARDS
This study tests whether a customized breathing machine approach ("precision ventilation") is better than usual care for patients with ARDS. The goal is to improve oxygen levels and recovery while avoiding lung damage.
Cincinnati, OhioAges 18 years+ - NCT01902407Enrolling by invitation
Sleep scan study using computer models in people with Down syndrome
This study uses computer simulations to understand breathing airways and lung changes during sleep in people with Down syndrome. It may help researchers better interpret sleep MRI/CT scans and improve how sleep apnea (OSA) is studied in the future.
Cincinnati, OhioAges 1–90 - NCT06056908Recruiting
Shwachman Diamond Syndrome Registry and Study
This study is creating a registry for people with Shwachman-Diamond Syndrome (SDS) or similar conditions, and their family members. It aims to learn more about the condition and improve care by collecting health information over time.
Cincinnati, OhioAges Any age - NCT06366464RecruitingPhase 3
Study of a drug for sleepiness in Prader-Willi syndrome
This trial tests a medication called pitolisant to see if it helps reduce excessive daytime sleepiness in people with Prader-Willi syndrome. You or your loved one may be able to join if they have a confirmed diagnosis and a caregiver who can regularly help with study tasks.
Cincinnati, OhioAges 6 years+ - NCT06088589Recruiting
Speech-in-noise in autism and fragile x
This study measures how well people with autism or fragile X syndrome perceive speech in noisy settings, compared to typically developing individuals. It uses EEG to understand brain activity during listening tasks.
Cincinnati, OhioAges 15–35 - NCT07281079RecruitingPhase 3
Testing NNZ-2591 for children with Phelan-McDermid syndrome
This trial tests a new medicine, NNZ-2591, to see if it helps children with Phelan-McDermid syndrome. It is for children aged 3 to 12 who have a specific genetic change (SHANK3) and weigh at least 10 kg.
Cincinnati, OhioAges 3–12 - NCT05219110Recruiting
More fluids for children sick with toxin E. coli
This study looks at whether giving extra (hyper) fluids early helps children with a high-risk E. coli stomach infection. The goal is to improve outcomes by supporting the kidneys during the illness.
Cincinnati, OhioAges 9 months–21 years - NCT07695298RecruitingPhase 4
Testing faricimab for a rare eye disease linked to histoplasmosis
This trial tests a drug called faricimab (brand name Vabysmo) for treating abnormal blood vessel growth in the back of the eye, caused by a past infection with histoplasmosis. The goal is to see if it helps improve vision over 52 weeks.
Cincinnati, OhioAges 18 years+ - NCT06668805RecruitingPhase 2
Study of vosoritide for children with Noonan syndrome and short stature
This trial tests a new drug, vosoritide, to help children with Noonan syndrome who are still growing but are shorter than expected despite growth hormone treatment. It aims to see if the drug can improve their growth.
Cincinnati, OhioAges 3–11
Hear when a new Down Syndrome trial opens near Cincinnati, OH
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Down Syndrome trials in other cities
Where these studies are running near Cincinnati
Institutions with a site for the recruiting down syndrome studies listed above.
- Cincinnati Children's Hospital Medical Center · 15 studies
- Neuren PMS-301 Site#108 · 2 studies
- Cincinnati Eye Institute
- CTI Clinical Research Center
- Gastro Health Research
- GSK Investigational Site
- Mercy Health
- Research Site
What taking part in a down syndrome study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting down syndrome studies in Ohio.
Common questions
- Are there down syndrome clinical trials near Cincinnati?
- Yes. We're currently tracking 58 recruiting down syndrome studies with a site near Cincinnati, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a down syndrome study near Cincinnati?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Cincinnati to take part?
- Not necessarily. These studies have a site near Cincinnati, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New down syndrome studies open near Cincinnati regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.