Clinical trials · Nashville, TN
Down Syndrome clinical trials in Nashville
We’re tracking 65 recruiting down syndrome studies with a site in or near Nashville — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Nashville
- NCT04064060RecruitingPhase 3
Long-term safety follow-up for luspatercept study participants
This trial studies the long-term safety of luspatercept (ACE-536) in people who already took part in an earlier luspatercept study. It mainly helps doctors better understand ongoing side effects and overall safety over time.
Nashville, TennesseeAges 18 years+ - NCT06112418Recruiting
Personalized vs standard care to prevent heart attacks
This trial compares two ways to prevent heart attacks and strokes: one uses a special heart CT scan to guide care, the other uses standard risk factors like blood pressure and cholesterol. You may be eligible if you are older (men over 55, women over 65) and have diabetes, prediabetes, or metabolic syndrome.
Nashville, TennesseeAges 55 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Nashville, TennesseeAges birth–20 years - NCT06014931Recruiting
Recovery support after ICU stay
This study uses telehealth to help older adults recover after a serious ICU illness, like being on a breathing machine or having sepsis. It tests whether virtual check-ins can improve your recovery at home.
Nashville, TennesseeAges 45 years+ - NCT07742735RecruitingPhase 3
Study of apraglutide for short bowel syndrome with intestinal failure
This study tests a new medicine called apraglutide, given as a shot, to see if it can help adults with short bowel syndrome and intestinal failure reduce their need for intravenous nutrition (parenteral support). The study compares apraglutide to a placebo (a shot with no medicine) to check if it is safe and effective.
Nashville, TennesseeAges 18 years+ - NCT07146516Recruiting
Preventing retinal detachment in Stickler syndrome with laser
This study tests whether a preventative laser treatment can lower the risk of retinal detachment in people with Stickler syndrome. It's for those who have not yet had a retinal detachment and are healthy enough for the procedure.
Nashville, TennesseeAges Any age - NCT06899178RecruitingPhase 2
Atomoxetine for genetic obesity due to MC4R changes
This trial tests a medicine called atomoxetine (Strattera) to help people with a specific genetic form of obesity lose weight. It may be an option if you have a change in the MC4R gene and have not used certain other medications recently.
Nashville, TennesseeAges 6 years+ - NCT04726241RecruitingPhase 1/Phase 2
Testing blood and bone marrow samples in young leukemia patients
This trial looks at blood and bone marrow samples from children and teens whose leukemia has come back or is hard to treat. The goal is to better understand the disease and guide future options for these patients.
Nashville, TennesseeAges Up to 22 years - NCT04851678Recruiting
Study how stress affects adults with Tourette syndrome
This study follows adults with Tourette syndrome over time to better understand how stressors affect symptoms and daily life. It may help researchers learn what factors make symptoms better or worse and improve future care.
Nashville, TennesseeAges 18 years+ - NCT07216443RecruitingPhase 2
Study of orca-t for leukemia or MDS with reduced intensity chemo
This trial tests a new cell therapy, orca-t, given after a lower-intensity chemo and radiation regimen for people with acute myeloid leukemia, mixed phenotype leukemia, or myelodysplastic syndrome. It aims to help patients who cannot tolerate full-intensity transplant conditioning.
Nashville, TennesseeAges 18 years+ - NCT03851484Recruiting
Study sensory symptoms in people with Tourette-related tics
This study looks at sensory symptoms in adults who have Tourette syndrome or similar long-term tic disorders. Your answers to questionnaires may help researchers understand these symptoms and how they relate to the condition.
Nashville, TennesseeAges 18 years+ - NCT07422480RecruitingPhase 3
Comparing elritercept to epoetin alfa for anemia in MDS needing transfusions
This trial tests a new drug called elritercept against a standard treatment, epoetin alfa, for people with a low-risk form of MDS who need regular blood transfusions for anemia. The goal is to see if elritercept works better to reduce the need for transfusions.
Nashville, TennesseeAges 18 years+ - NCT02646839Enrolling by invitationPhase 2
Testing a gene-matched transplant approach for childhood leukemia
This trial studies a specific type of partially matched (haploidentical) stem cell transplant in children with ALL, AML, or MDS. It looks at whether using certain immune system gene patterns (KIR) and measuring leftover disease after treatment can improve outcomes and cost-effectiveness.
Nashville, TennesseeAges Up to 21 years - NCT07450664Enrolling by invitation
Observational study of VYKAT XR for Prader-Willi syndrome
This study follows people with Prader-Willi syndrome who are already taking or starting VYKAT XR, including those switching from an earlier version of the drug (DCCR). It aims to understand how the treatment works in everyday life.
Nashville, TennesseeAges 4 years+ - NCT07519395RecruitingPhase 2
Camlipixant for IBS with diarrhea or mixed symptoms
This study tests an investigational drug, camlipixant, to see if it can reduce belly pain and diarrhea or mixed bowel symptoms in adults with irritable bowel syndrome (IBS). If you've tried other IBS treatments without enough relief, this might be an option.
Nashville, TennesseeAges 18–80 - NCT05133245Enrolling by invitation
Study of genes in people with PHACE syndrome
This study looks at genetic (DNA) differences in people who have PHACE syndrome. It also includes an eye exam, and results may help doctors better understand the condition.
Nashville, TennesseeAges Any age - NCT07156318Recruiting
Drumming lessons for children with Down syndrome
This study tests whether drumming lessons can help children with Down syndrome. It may help with coordination, focus, or mood.
Nashville, TennesseeAges 7–15 - NCT04093570Enrolling by invitationPhase 2
Extension study for people continuing ASTX727 from a prior trial
This study checks whether continuing ASTX727 for people who already benefited from it in an earlier Taiho study is safe and effective. It may be an option if you stayed on ASTX727 at the end of your parent study and your doctor felt it was helping you.
Nashville, TennesseeAges 18 years+ - NCT06901245RecruitingPhase 4
Tirzepatide for young adults with obesity
This study tests the diabetes/weight-loss drug tirzepatide (Mounjaro) in young adults aged 18–26 who have obesity and either Prader-Willi syndrome, hypothalamic obesity, or general obesity. It looks at whether a weekly injection can help with weight management.
Nashville, TennesseeAges 18–26 - NCT04988555RecruitingPhase 1/Phase 2
Study of an investigational drug for high-risk acute leukemia
This Phase 1/2 study tests enzomenib (DSP-5336) in people with relapsed or hard-to-treat acute leukemia (and, in some places, certain other blood cancers). The goal is to see how the drug works and how safe it is, especially for leukemia cases with specific genetic changes (KMT2A/MLL or NPM1).
Nashville, TennesseeAges 12 years+ - NCT04507997Recruiting
Study of the natural course of Angelman syndrome
This study follows people with Angelman syndrome to understand how their symptoms and development change over time. It may help researchers better describe the condition and support future treatments.
Nashville, TennesseeAges Any age - NCT05654922RecruitingPhase 3
Prevent lung transplant airways scarring with ARINA-1
This Phase 3 trial tests ARINA-1 to slow or prevent worsening lung transplant scarring in the breathing tubes (bronchiolitis obliterans). It may help people who are showing early decline in lung function but are not yet at advanced disease.
Nashville, TennesseeAges 18–75 - NCT06994676RecruitingPhase 1
Study of CBX-250 for advanced myeloid leukemias
This study tests an experimental drug, CBX-250, for people with certain advanced blood cancers (like AML) that have not responded to standard treatments or have returned. The drug works only for people who have a specific genetic marker (HLA-A*02:01). The goal is to see if it is safe and how well it works.
Nashville, TennesseeAges 12 years+ - NCT05231798RecruitingPhase 2
PET and brain scans in adults with Down syndrome
This study looks at how well a brain chemical system works in adults with Down syndrome as they age, including how it relates to Alzheimer’s-type brain changes and thinking skills. It uses brain scans and memory/thinking tests to see whether these measures can help track risk or changes over time.
Nashville, TennesseeAges 18–55
Hear when a new Down Syndrome trial opens near Nashville, TN
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Down Syndrome trials in other cities
Where these studies are running near Nashville
Institutions with a site for the recruiting down syndrome studies listed above.
- Vanderbilt University Medical Center · 10 studies
- Monroe Carell Jr. Children's Hospital at Vanderbilt · 2 studies
- Vanderbilt Ingram Cancer Center · 2 studies
- GSK Investigational Site
- Sarah Cannon Cancer Institute
- Soleno Clinical Site
- Tennessee Oncology, PLLC
- Tennessee Retina, P.C.
What taking part in a down syndrome study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting down syndrome studies in Tennessee.
Common questions
- Are there down syndrome clinical trials near Nashville?
- Yes. We're currently tracking 65 recruiting down syndrome studies with a site near Nashville, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a down syndrome study near Nashville?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Nashville to take part?
- Not necessarily. These studies have a site near Nashville, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New down syndrome studies open near Nashville regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.