Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,055 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06793072Recruiting
Adipokines in PCOS trial
This study looks at certain proteins (adipokines) in the blood of people with polycystic ovary syndrome (PCOS) to see how they relate to the condition. It may help researchers better understand PCOS.
KrakowAges 18–45 - NCT06793670RecruitingPhase 4
Landiolol study for mitral valve surgery patients
This trial tests a short-acting beta-blocker called Landiolol given during mitral valve surgery to see if it helps the heart recover after surgery. It is for patients who have certain signs of heart strain before their operation.
Alessandria, PiedmontAges 18 years+ - NCT06793085Recruiting
Inflammation Proteins in PCOS Study
This study looks at inflammation-related proteins in women with PCOS to understand what causes the condition. If eligible, you’d help researchers learn more about PCOS, which could lead to better treatments.
KrakowAges 18–45 - NCT05705999Recruiting
TMS treatment plus CBIT study for Tourette’s tics
This trial tests whether a treatment called TMS, added to an evidence-based therapy called CBIT, can reduce Tourette’s tics more than CBIT alone. You may be assigned to different study groups, and they will also use brain imaging to measure changes.
Morgantown, West VirginiaAges 18–100 - NCT05871216Recruiting
Study of joint instability in people with loose joints
This trial is testing how to assess and manage joint instability in people who have unusually loose (hypermobile) joints. If you have moderate to severe loose joints, you may be able to join after screening checks like movement tests and health history.
BolognaAges 18–60 - NCT06789445RecruitingPhase 1/Phase 2
Cell therapy for inherited retinal disease (CLARICO)
This study tests a new cell therapy (OpCT-001) for adults with inherited retinal diseases that affect the light-sensing cells. It aims to see if the treatment is safe and possibly helps improve vision.
Los Angeles, CaliforniaAges 18 years+ - NCT06788509Enrolling by invitationPhase 1
Continued treatment and safety monitoring after a parent study
This trial allows people who were already getting study treatment in a previous trial to keep receiving it and be monitored for safety. It is designed for those who have not had serious side effects or disease worsening.
Macquarie UniversityAges 18 years+ - NCT06792799RecruitingEarly Phase 1
CAR-NK cells for B-cell autoimmune diseases
This early phase trial tests a new treatment made from immune cells (CAR-NK cells) that target and destroy overactive B cells. It may help people with lupus, certain kidney diseases, or nephrotic syndrome that hasn't responded to standard therapies.
Hangzhou, ZhejiangAges 3 years+ - NCT06788431RecruitingEarly Phase 1
Study of IMC-001 to stabilize heart artery plaque
This trial tests an investigational drug, IMC-001, to see if it can make artery plaques in the heart more stable and less likely to cause a heart attack. You may be eligible if you've recently had a heart attack or unstable angina and have a specific type of soft plaque in your arteries.
Nanyang, HenanAges 18–75 - NCT06783998Enrolling by invitation
Breathing muscle health in sleep apnea
This trial studies how sleep apnea affects the muscles you use to breathe. It may help doctors better understand and treat breathing problems in people with sleep apnea.
Mersin, MersinAges 18 years+ - NCT06784154Recruiting
HIV and heart attack risk: a study on hidden body fat
This study looks at how hidden fat deep inside the body (ectopic fat) might increase heart attack risk in people living with HIV. By joining, you will help researchers understand this link and find better ways to protect your heart.
LiverpoolAges 40 years+ - NCT06482671RecruitingPhase 3
Rikkunshito for newly diagnosed functional dyspepsia
This trial tests a herbal medicine called rikkunshito for people newly diagnosed with functional dyspepsia (stomach pain or discomfort). It aims to see if the treatment can improve symptoms in adults who fit certain health requirements.
Leuven, Vlaams-BrabantAges 18 years+ - NCT05219617RecruitingPhase 3
Carisbamate for frequent drop seizures in Lennox-Gastaut
This Phase 3 study tests whether carisbamate can reduce drop seizures in people with Lennox-Gastaut syndrome (LGS). It also checks whether the treatment is safe when added to existing seizure medicines.
Palo Alto, CaliforniaAges 4–55 - NCT05736146Recruiting
Testing Gulf War illness blood markers for better diagnosis
This study checks blood tests to see whether they can help confirm Gulf War illness. If you qualify as having Gulf War illness (or are a similar Gulf War veteran without it), your blood and health information may be used to validate these marker tests.
Palo Alto, CaliforniaAges 35 years+ - NCT06776549Recruiting
Cooling or normal temperature after cardiac arrest with ECMO
This trial tests if cooling the body (hypothermia) or keeping normal body temperature (normothermia) after emergency heart-lung support (ECMO) improves survival in adults who had a cardiac arrest outside the hospital.
Kurume, FukuokaAges 18–75 - NCT06773871Recruiting
Exercise study for low-risk myeloid cancers and precursor conditions
This trial tests whether exercise is safe and feasible for people with low-risk myeloid cancers or certain bone marrow conditions. It aims to see if a supervised exercise program can be done without problems.
Copenhagen, DenmarkAges 18 years+ - NCT06765057RecruitingPhase 2/Phase 3
Probiotics for Depression and Metabolic Health
This trial tests whether taking a probiotic supplement can improve both depression symptoms and metabolic health (like waist size, blood sugar, and cholesterol) in people with major depression. It may be a good fit if you are already on an antidepressant and have signs of metabolic syndrome.
Riyadh, Riyadh RegionAges 18–65 - NCT06760546RecruitingPhase 3
Testing setmelanotide for weight gain after brain injury
This trial tests a daily injection called setmelanotide to see if it can help people who have gained weight due to a brain injury or condition affecting the hypothalamus. It may help reduce hunger and support weight loss.
Birmingham, AlabamaAges 4 years+ - NCT06771505Recruiting
New quality of life tool for short bowel patients
This study aims to create a new tool to measure quality of life in people with short bowel syndrome. By comparing it to a standard questionnaire, researchers hope to better understand how the condition affects daily life and well-being.
Pierre-BéniteAges 18–99 - NCT06758830RecruitingPhase 2/Phase 3
Total neoadjuvant therapy vs surgery for rectal cancer
This trial tests whether a full course of chemotherapy and radiation before any surgery (called total neoadjuvant therapy) can help you avoid surgery and preserve your rectum. It is for people with a specific early stage of rectal cancer that has not spread.
VilniusAges 18 years+ - NCT06758986Enrolling by invitation
Gender and shoulder pain study
This study looks at whether gender affects shoulder pain from subacromial impingement. It may help tailor future treatments.
Kırşehir, MerkezAges 18–65 - NCT06757543Recruiting
Comparing video vs direct laryngoscopy for newborn intubation
This study compares two ways of putting a breathing tube into newborn babies: using a video camera to see the airway versus the standard method of looking directly. It aims to find which technique is safer and more effective.
RijekaAges birth–1 month - NCT06754020Recruiting
Traditional Chinese tongue diagnosis for myasthenia gravis
This study uses tongue imaging and traditional Chinese medicine methods to compare tongue features between people with myasthenia gravis and healthy individuals. It may help understand how tongue diagnosis relates to this condition.
New Taipei City, Tamsui DistrictAges 20 years+ - NCT04639388Recruiting
Learning about psychosis in children with 22q11.2 deletion syndrome
This study looks at how “psychotic disorders” (like unusual beliefs, hallucinations, or thought changes) show up in children with 22q11.2 deletion syndrome. It mainly focuses on understanding the condition and may help improve care in the future.
Lyon, Auvergne-Rhône-AlpesAges 4–13
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,055 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.