Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,055 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05782556Recruiting
Freiburg TIPS Registry for portal hypertension patients
This is a registry study that collects information from people who need a procedure called TIPS for portal hypertension. It may help doctors better understand outcomes and care for both cirrhotic and non-cirrhotic causes of portal hypertension.
Freiburg im BreisgauAges 18–100 - NCT05808036Recruiting
Test a diet app for IBS symptoms using the DOMINO diet
This trial studies whether a specific diet plan delivered through a phone app (the DOMINO diet) can improve symptoms in people with irritable bowel syndrome (IBS). It may help by changing what you eat to reduce gut symptoms, compared with standard care rules in the study.
LeuvenAges 18–70 - NCT05783245Recruiting
Cooling therapy to reduce pain after open carpal tunnel surgery
This trial studies whether cooling (cold therapy) can lessen pain after open carpal tunnel release surgery. If you’re having this surgery, your answers to questionnaires and your current pain-medication status will determine whether you can join.
Chicago, IllinoisAges 18 years+ - NCT05799768Enrolling by invitation
Ketogenic diet for rheumatoid arthritis symptoms and inflammation
This study tests whether a very low-carbohydrate, ketogenic diet can improve rheumatoid arthritis (RA). It’s designed for people whose RA treatment is already stable and who are not currently using a keto diet or certain medicines.
Oklahoma City, OklahomaAges 18–65 - NCT05782582Recruiting
Testing care for long-term heart artery symptoms in primary care
This study looks at people who come to primary care with symptoms that may be caused by long-term narrowing of heart arteries. The goal is to test an approach for identifying and managing this condition earlier or more accurately in everyday care.
LinköpingAges 18 years+ - NCT05800210RecruitingPhase 2
T cell and B cell immune “wipeout” after stem cell transplant
This Phase 2 trial studies whether removing certain immune cells (alpha/beta T cells and CD19+ B cells) around the time of a stem cell transplant can improve outcomes for people with high-risk blood cancers. It may help by reducing the immune responses that can interfere with the transplant working, while keeping the process safe.
Gainesville, FloridaAges 6 months–39 years - NCT05796388Recruiting
Virtual reality and linaclotide for IBS with constipation
This study tests whether virtual reality (VR) plus linaclotide can improve symptoms and quality of life in adults with IBS-C (IBS with constipation). You may be asked to use VR and take a study medicine, while doctors check that your IBS diagnosis fits strict criteria.
Jacksonville, FloridaAges 18–70 - NCT05807932RecruitingPhase 1/Phase 2
Venetoclax added to conditioning before stem cell transplant
This trial tests adding venetoclax to a standard “conditioning” chemotherapy plan before an allogeneic stem cell transplant (using a donor) for certain bone marrow cancers. It aims to improve how well the transplant works and how safe this combination is for people with MDS, CMML, or sAML.
Aachen, North Rhine-WestphaliaAges 18 years+ - NCT05801224Recruiting
Inhaled nitric oxide for lung injury in intensive care
This study tests whether giving inhaled nitric oxide gas helps improve lung function in patients on a breathing tube with mild to moderate acute lung injury (ARDS). Participants will receive standard care plus the study gas, and the team will use special imaging to see how the lungs respond.
Boston, MassachusettsAges 18–80 - NCT05804773Recruiting
Studying brain blood flow changes when blood pressure changes
This study looks at how blood flow in the brain changes when blood pressure rises or falls in people in the ICU. It may help doctors understand safer ways to manage blood pressure in critically ill patients.
Paris, FranceAges 18 years+ - NCT05806801Recruiting
Study how weight loss changes the body with or without exercise
This study looks at how your metabolism (how your body uses energy and controls blood sugar/fats) changes during weight loss, comparing weight loss alone versus weight loss plus exercise. It may help researchers understand what body changes happen with different approaches and why.
Ann Arbor, MichiganAges 18–40 - NCT05795140RecruitingPhase 3
Long-term safety study of iptacopan for aHUS
This study follows people with aHUS who are already taking iptacopan to check how well it continues to work and how safe it is over the long term. You may be asked to keep taking the study medicine and follow extra safety rules, including infection and pregnancy precautions.
São Paulo, São PauloAges 18–100 - NCT04943562Recruiting
Testing sleep sensors to score your sleep stages
This study checks whether wearable sensors (like a sleep band and a wearable EEG) and a phone can accurately identify your sleep stages. It includes healthy people and people with sleep problems to see how well the devices work and whether results match a standard sleep lab test.
São Caetano do Sul, São PauloAges 20–80 - NCT05767658Recruiting
Online messages to support safer infant care
This study tests whether online social network posts and text messages can help pregnant people practice safer infant care after birth. It may help you feel more prepared about feeding and safe sleep.
Boston, MassachusettsAges Any age - NCT05776511Recruiting
Eye Movement Test for White Matter Brain Changes
This study tests whether a special eye-tracking camera can help diagnose the cause of white matter hypersignals—unusual bright spots seen on brain MRI. Researchers want to see if eye movements can reveal clues about what's causing these brain changes.
NiceAges 18 years+ - NCT05776914RecruitingPhase 2
Fecal transplant to treat moderate to severe IBS symptoms
This trial tests whether putting stool (fecal microbiota) from a donor into your bowel can improve symptoms in people with IBS who are not IBS-C. It may help by changing the gut bacteria that can influence IBS symptoms.
Rochester, MinnesotaAges 18–70 - NCT05767671Recruiting
Breathing tube patients in ICU tested for lung inflammation treatment
This trial studies whether changing immune cells in the lungs (using a procedure called MiniBAL) can improve outcomes in adults who are critically ill and on a breathing tube. It may help doctors better manage acute lung injury by targeting inflammation early in the ICU stay.
Denver, ColoradoAges 18–99 - NCT05737121RecruitingPhase 2
Study drug for bladder pain compared with lidocaine, heparin, or placebo
This Phase 2 trial tests VNX001 to see if it helps people with interstitial cystitis/bladder pain syndrome (IC/BPS) compared with its separate ingredients (lidocaine and heparin) or a placebo (inactive treatment). You may be eligible if you have had IC/BPS for months and recently had a moderate-to-severe bladder pain flare.
Escondido, CaliforniaAges 18 years+ - NCT03300492RecruitingPhase 1/Phase 2
Natural killer cell treatment after a half-matched stem cell transplant
This early trial studies adding special immune cells called “natural killer cells” after a half-matched stem cell transplant for AML or MDS. The goal is to see if this approach improves outcomes and safety when there is no fully matched donor available.
BaselAges 18 years+ - NCT05726786RecruitingPhase 3
Immunonutrition before bladder removal surgery
This study tests whether a special nutrition drink given before open bladder surgery can reduce complications and improve the body’s immune response after surgery. It’s for adults having bladder removal and is compared against standard care.
Lausanne, Canton of VaudAges 18 years+ - NCT05724173Recruiting
Test of a brain-to-computer device for ALS hand paralysis
This study checks whether a brain-computer interface (a BrainGate2 system) is safe and workable for people with ALS. If you qualify, you may be asked to try the device and complete study tasks to help researchers learn how well it can support communication or control.
Stanford, CaliforniaAges 18–80 - NCT05194397RecruitingPhase 2
Exercise plus NR supplement to boost fitness after stem-cell transplant
This trial tests whether a supervised exercise program, plus an NR supplement, can improve fitness in young people who have had an allogeneic (donor) stem-cell transplant for certain blood cancers or bone marrow conditions. It’s meant to help with energy and physical ability while monitoring safety.
Duarte, CaliforniaAges 10–30 - NCT05687149Recruiting
Study of mouth and throat cancer patterns in Fanconi anemia
This study looks at how squamous cell carcinoma (a type of cancer) naturally develops over time in people with Fanconi anemia. It may help doctors better recognize warning signs and plan care in the future.
Bethesda, MarylandAges 8–90 - NCT05701917Recruiting
Clot-busting device versus blood thinners for leg clot
This study compares a clot-removal device (ClotTriever) plus standard care versus standard blood thinners alone for a deep vein clot in the leg. It aims to see which approach better improves leg symptoms and outcomes.
Scottsdale, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,055 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.