Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,055 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05918861RecruitingPhase 3
Tested heart-risk drug for people with recent heart-attack genetics
This trial studies whether dalcetrapib can lower future heart and blood-vessel risk in people who recently had an ACS (acute coronary syndrome, often a heart attack or unstable chest pain) and have a specific genetic marker. It may help people like you by targeting a risk pathway related to that genetic background.
Alexander City, AlabamaAges 45 years+ - NCT05924646Recruiting
Testing salt to treat POTS symptoms
This study looks at whether adding salt helps improve POTS symptoms, especially the fast heart rate that happens when you stand. You’d be screened carefully to make sure your symptoms fit POTS and that other causes of fast heart rate are unlikely.
Calgary, AlbertaAges 18–60 - NCT05914649Recruiting
Testing long COVID and POTS brain fog symptoms
This study tests how different long-COVID and POTS-related symptoms—especially “brain fog”—show up and improve. It may help researchers better measure symptoms so future treatments can be targeted more effectively.
Calgary, AlbertaAges 18–60 - NCT05922761RecruitingPhase 2
Belumosudil for lung scar prevention or treatment after transplant
This Phase 2 study tests belumosudil to treat or prevent bronchiolitis obliterans (BOS), a lung complication that can happen after a stem cell transplant. If you qualify, you would be checked closely with breathing tests and scans, and watched for safety and whether lung function improves or stays stable.
Stanford, CaliforniaAges 18 years+ - NCT05881005Recruiting
NAC for fatty liver in people with active Cushing’s
This study tests whether NAC (a supplement/medicine) can improve liver health in adults who have active Cushing’s syndrome and fatty liver disease. It may help if your excess stress hormone levels are affecting your liver.
AngersAges 18 years+ - NCT05903950Recruiting
Air pollution study to help lower blood pressure
This trial tests whether an air-pollution–reduction approach in your home can help lower blood pressure. It focuses on adults with mildly high blood pressure and certain metabolic health markers.
DohaAges 18–60 - NCT05900466RecruitingPhase 2
Metformin for fibromyalgia symptom relief
This study tests whether metformin, a diabetes medicine, can reduce fibromyalgia symptoms. If you have fibromyalgia and can take pills safely, you may be able to join and help answer whether metformin can help.
Salt Lake City, UtahAges 18–75 - NCT05880758Recruiting
Studies how yo-yo sleep affects heart and metabolism health
This study looks at what happens to heart-related health and body metabolism when your sleep goes through ups and downs (yo-yo sleep). You may be asked about your sleep habits and health history to see whether your body changes in response to different sleep patterns.
New York, New YorkAges 18–49 - NCT05884333RecruitingPhase 2
Cord blood transplant for adults with blood cancer
This Phase 2 study tests using donated cord blood to treat certain adult blood cancers that are at high risk of coming back. It may help strengthen the body’s ability to rebuild blood and fight the cancer after intensive treatment.
New York, New YorkAges 21–65 - NCT05905926Enrolling by invitationPhase 3
Tenapanor safety study for teens with constipation-predominant IBS
This trial checks the safety of tenapanor in children and teens (ages 6 to under 18) with IBS-C. It is only for people who finished a previous related study and agreed to continue follow-up.
Foley, AlabamaAges 6–18 - NCT05905328RecruitingPhase 1/Phase 2
New drug to prevent and treat side effects of CAR T-cell therapy
This study tests an experimental drug, CTO1681, that may help prevent or treat cytokine release syndrome (CRS) — a common side effect of CAR T-cell therapy. It could make the recovery period safer and more comfortable.
Orange, CaliforniaAges 18 years+ - NCT03606200Recruiting
Join a registry for primary ciliary dyskinesia
This study is a registry that collects information from people diagnosed with primary ciliary dyskinesia. It may help researchers better understand the condition over time and improve future care.
BernAges Any age - NCT04966624Recruiting
Ultrasound-guided breathing strategy for new focal ARDS
This study tests a way to guide ventilator settings using lung ultrasound pictures in adults with very new, localized ("focal") ARDS. The goal is to see whether this approach improves care for people who just started needing a breathing machine.
DijonAges 18 years+ - NCT05849662RecruitingPhase 1/Phase 2
Trametinib plus azacitidine for newly diagnosed JMML
This trial studies whether trametinib and azacitidine can control juvenile myelomonocytic leukemia (JMML) soon after diagnosis. It’s designed to test safety and how well the treatment works in children and young adults who meet specific leukemia and genetic criteria.
Phoenix, ArizonaAges 1 month–21 years - NCT05875805Recruiting
Telehealth planning for future care decisions
This trial tests a telehealth (video or phone) program that helps people with certain blood cancers plan their future care preferences. It may help you and your chosen support person communicate your wishes clearly, especially if you become too sick to speak for yourself.
Rochester, New YorkAges 60 years+ - NCT05857696Recruiting
Spinal Stimulation to Improve Walking in Chronic Back and Leg Pain
This pilot study tests whether a special spinal cord stimulator—a small device that sends gentle electrical signals to your spinal cord—can help you walk better if you have ongoing nerve pain in your lower back and leg after spine surgery. The goal is to reduce pain and improve your ability to move around.
NiceAges 18–70 - NCT05873712RecruitingPhase 2
Zanubrutinib plus CAR-T for Richter syndrome
This Phase 2 trial tests whether a combination of zanubrutinib (an oral medicine) and CAR-T cell therapy can treat Richter syndrome, a type of lymphoma that develops in people with CLL/SLL. It may help shrink tumors and improve outcomes after the disease comes back or doesn’t respond to prior treatment.
New York, New YorkAges 18 years+ - NCT05868668Recruiting
Low-intensity shockwave versus wave therapy for erectile and pelvic pain
This trial compares two types of low-intensity wave therapy to see which works better for erectile dysfunction and/or chronic pelvic pain. Participants may benefit if these therapies improve erection quality and reduce pelvic pain.
Cleveland, OhioAges 40 years+ - NCT05855317Recruiting
Tests blood marker link to lung blood clots in ARDS
This study looks at a blood marker (EV-TF) to see whether it helps predict pulmonary embolism—blood clots in the lungs—in people with ARDS who are in the ICU. Results may help doctors better identify who is at higher risk.
MarseilleAges 18 years+ - NCT05236465Recruiting
3-day course for CFS/ME to help you manage symptoms
This trial tests whether a short, structured 3-day course can help people with CFS/ME (myalgic encephalomyelitis/chronic fatigue syndrome) through education and support for symptom management. It may be most helpful if you can currently step back from work or school and are ready to try changes.
TrondheimAges 18–65 - NCT05812339Enrolling by invitation
Mapping tests for stomach symptoms using body-surface sensors
This study checks whether a noninvasive “mapping” test placed on the belly and chest can help tell apart people with certain upper stomach symptoms from healthy controls. It may help researchers better understand stomach function and symptoms without relying only on invasive tests.
Calgary, AlbertaAges 18 years+ - NCT05819697Recruiting
Helping burning mouth symptoms with improved memory recall
This trial looks at ways to reduce how much people with burning mouth syndrome struggle to recall information during the study. If you qualify, you may be asked to complete study tasks and share saliva to support the research.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05787379Recruiting
Care program for Veterans with long-lasting COVID symptoms
This trial tests a care approach for Veterans who have long-COVID—aiming to improve symptoms and follow-up care through participating VA clinicians. You may be included if you are a Veteran with long-COVID and can be seen by a participating clinician soon, unless you had severe COVID requiring ICU care.
East Orange, New JerseyAges Any age - NCT04611516Recruiting
Study of ear, nose, and throat checks in PCD patients
This study follows people with primary ciliary dyskinesia (PCD) and looks at their regular ear, nose, and throat (ENT) checkups over time. Your participation may help doctors better understand how ENT care should be followed in PCD.
BernAges Any age
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,055 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.