Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,048 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07381985Enrolling by invitation
Managing hereditary cancer risk in rural areas
This study tests a way to help people with inherited cancer gene mutations manage their health, especially if they live in rural areas. You join if you found out about the mutation more than a year ago.
Burlington, VermontAges 18 years+ - NCT06835868Recruiting
Registry for nerve stimulation treatments for chronic pain in Belgium
This trial creates a registry for people with chronic pain who are getting special nerve-modulating treatments in Belgium. It focuses on two specific chronic pain conditions: Persistent Spinal Pain Syndrome Type 2 (pain after spine surgery) and Complex Regional Pain Syndrome (a type of nerve pain).
Edegem, AntwerpAges Any age - NCT07234695RecruitingPhase 3
Levetiracetam to prevent seizures in adults with Down syndrome and Alzheimer's
This trial tests if levetiracetam, a seizure medication, can prevent seizures in adults with Down syndrome who also have Alzheimer's disease. It aims to help manage a common complication and improve quality of life.
Granada, AndalusiaAges 40 years+ - NCT06780293RecruitingPhase 2
Laser acupuncture for dry eye and Sjogren's dry eye
This study tests if laser acupuncture can help people with dry eye symptoms, including those with Sjogren's syndrome, which causes dryness in the eyes and mouth. It may be a good fit if you have dry eye or Sjogren's and meet the age and eye test requirements.
Taipei, TaiwanAges 20–75 - NCT07196397Recruiting
Polish Registry of Heart Nerve Procedures
This registry tracks people who have had or plan to have a procedure that changes the nerves controlling heart rate, such as cardioneuroablation. It aims to better understand and treat conditions like inappropriate tachycardia, POTS, and fainting spells.
RzeszówAges 18 years+ - NCT07201012Recruiting
Finding skin tumors in Lynch syndrome patients
This study looks for Muir-Torre syndrome, a condition that causes certain skin tumors, in people who already have Lynch syndrome. It may help doctors understand how common this skin condition is in Lynch syndrome patients.
Nîmes, GardAges Any age - NCT06005844Recruiting
Testing a new scale for thinking and mood problems in cerebellum disorders
This study tests a new questionnaire (CCASS) to screen for cognitive-affective syndrome in people with cerebellar damage. It aims to see if the French version works well to identify thinking and mood changes caused by cerebellar disease.
Mulhouse, Haut-RhinAges 18 years+ - NCT07000851Recruiting
Brain Imaging Study in Corticobasal Syndrome
This study uses MRI scans to look at the brain in people with Corticobasal Syndrome (CBS). It aims to better understand the condition and may help find better ways to diagnose or treat it.
Rochester, MinnesotaAges 18 years+ - NCT06915077Enrolling by invitation
Personalized treatment for sleep apnea
This study tests alternative treatments for people with moderate to severe sleep apnea who cannot use CPAP. It aims to find more tolerable options.
Wilrijk, AntwerpenAges 18 years+ - NCT06914726Enrolling by invitation
Cancer risk follow-up care for hereditary syndromes
This study tests a tool to help primary care doctors provide better cancer prevention care for people with hereditary breast and ovarian cancer (HBOC) or Lynch syndrome (LS). It aims to ensure you're up-to-date on recommended screenings and preventive steps.
Minneapolis, MinnesotaAges 18 years+ - NCT06904872RecruitingPhase 2
Testing a diarrhea drug for short bowel syndrome without a colon
This trial tests if crofelemer can reduce diarrhea and fluid loss in people with short bowel syndrome who have a stoma (no colon connection) and need intravenous nutrition or fluids. The goal is to see if it improves gut function and quality of life.
AachenAges 18 years+ - NCT04777760Recruiting
Surfactant treatment for newborn breathing distress
This trial looks at giving a “surfactant” medicine (a substance that helps keep baby lungs open) to newborns who have serious breathing problems soon after birth. It may help babies with neonatal respiratory distress or acute breathing distress, especially if they’re treated in the early time window.
Chongqing, Chongqing MunicipalityAges 1 minute–1 day - NCT06838143Recruiting
Ilaris real-world study for periodic fevers and sJIA
This study watches how people with certain periodic fever syndromes or a severe type of childhood arthritis (sJIA) do on the medicine Ilaris during their regular doctor visits. It collects information to see how well the medicine works in everyday care.
SeoulAges 2–100 - NCT06647641Recruiting
Genetics study for PSP, CBS, MSA, and related conditions
This study looks at genetic factors in people with PSP, CBS, MSA, or similar brain conditions, and also in their family members. It involves genetic testing to learn more about these diseases and may help find new treatments.
Boston, MassachusettsAges 35 years+ - NCT06511050RecruitingPhase 1/Phase 2
Testing Lumbrokinase for Long COVID, Lyme, and Chronic Fatigue
This trial tests a supplement called Lumbrokinase (derived from earthworms) to see if it helps reduce symptoms in people with Long COVID, post-treatment Lyme disease syndrome, or ME/CFS. It may benefit those whose daily life is significantly affected by these conditions.
New York, New YorkAges 18 years+ - NCT06484062RecruitingPhase 1
Testing cirtuvivint alone and with ASTX727 for leukemia and MDS
This trial tests a new drug called cirtuvivint, given alone or with another drug (ASTX727), for people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) that has come back or not responded to treatment, and for people with high-risk MDS who have not been treated before. The goal is to see if these combinations work better than current options.
New Haven, ConnecticutAges 18 years+ - NCT06306157Enrolling by invitationPhase 4
Low dose naltrexone for complex regional pain syndrome
This trial tests whether a low dose of naltrexone, a medication that may help calm overactive immune and pain signals, can reduce pain and improve daily life in people with complex regional pain syndrome (CRPS), a chronic condition that often causes severe pain and swelling.
New York, New YorkAges 18–85 - NCT06299683Recruiting
Pain type and bladder pain syndrome treatment study
This study is testing if the type of pain you feel can help predict which treatments work best for interstitial cystitis (a condition that causes bladder pain and pressure). It may help match you with more effective care.
Franklin, TennesseeAges 18 years+ - NCT06092346Recruiting
Understanding rare purine and pyrimidine metabolism disorders
This study aims to learn more about rare disorders of purine and pyrimidine metabolism (DPPM), which can affect the brain, immune system, kidneys, and muscles. Researchers will study people with these disorders, their family members, and healthy volunteers to better understand the condition over time.
Bethesda, MarylandAges 1 month–100 years - NCT05851326Recruiting
Ultrasound and gentle stimulation for stubborn muscle pain
This trial tests whether low-energy ultrasound and electrical/magnetic stimulation can reduce long-lasting myofascial pain in the low back, neck, or tension-type headaches. It may help if your pain has lasted at least 3 months and is still noticeable despite your current treatment plan.
GrazAges 18–99 - NCT05702645Recruiting
Down syndrome long-term study after leukemia treatment
This study follows children and young adults with Down syndrome who have survived acute leukemia (ALL or AML) to learn about their longer-term health after treatment ends. It may help families and doctors understand what health problems to watch for and how to provide better follow-up care.
Birmingham, AlabamaAges 6–39 - NCT05704010Recruiting
Video pill camera test for Lynch syndrome
This trial studies whether a swallowable camera (video capsule endoscopy) can help look inside the small intestine for people with Lynch syndrome. It may help doctors detect problems earlier or more clearly by improving how the small bowel is checked.
Milan, LombardyAges 18 years+ - NCT05521958Enrolling by invitation
Gene activity study in severe leg muscle swelling after fracture
This study looks at gene activity (what genes are “turned on or off”) in the lower leg in people with acute compartment syndrome after a tibia (shin bone) injury. The goal is to better understand what is happening in the body and potentially guide future treatment decisions.
Salt Lake City, UtahAges 18–90 - NCT05432349Recruiting
Rett syndrome genetic registry for MECP2 changes
This trial is a registry that collects health and genetic information from people with Rett syndrome. It may help researchers better understand how MECP2 loss-of-function changes lead to symptoms and how to support patients.
Birmingham, AlabamaAges birth–99 years
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,048 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.