Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06529731RecruitingPhase 2
Interferon-Gamma and Donor Cells for Relapsed Leukemia After Transplant
This trial tests combining a protein called interferon-gamma with an infusion of donor white blood cells to treat AML or MDS that returned after a stem cell transplant. The goal is to see if this combination helps the donor cells attack the cancer more effectively.
St Louis, MissouriAges 18 years+ - NCT06501196RecruitingPhase 1
Study of BH-30236 for leukemia and high-risk MDS
This trial tests an experimental drug, BH-30236, for people with acute myeloid leukemia (AML) or a high-risk form of myelodysplastic syndrome (MDS) whose cancer has come back or stopped responding to treatment. It aims to see if the drug can help control the disease.
Duarte, CaliforniaAges 18 years+ - NCT06512584RecruitingPhase 3
Study of PJ009 for short bowel syndrome patients needing IV nutrition
This trial tests a new medicine called PJ009 for people with short bowel syndrome who need intravenous (IV) nutrition support. It aims to help reduce the need for IV nutrition. To join, you must have been dependent on IV nutrition for at least six months and be on a stable schedule.
Beijing, Beijing MunicipalityAges 14 years+ - NCT06499285RecruitingPhase 3
Study of a new drug to treat anemia in adults with low to intermediate risk MDS who need transfusions
This study tests a new drug called elritercept for people with myelodysplastic syndromes (MDS) who have low blood counts and need regular blood transfusions. The drug aims to boost red blood cell production and reduce or eliminate the need for transfusions, which can improve energy and quality of life.
Duarte, CaliforniaAges 18 years+ - NCT06502015Recruiting
Biomarkers in nervous system autoimmune diseases
This study looks for biomarkers (biological clues) in people with autoimmune diseases of the nervous system. It aims to discover better ways to diagnose and treat these conditions.
WuhanAges 18 years+ - NCT06502145RecruitingPhase 1
Iadademstat with hypomethylating agent for MDS
This trial tests a new oral medication (iadademstat) combined with a standard therapy called a hypomethylating agent for people with higher-risk myelodysplastic syndromes (MDS) or related blood cancers. The goal is to see if the combination is safe and effective.
Milwaukee, WisconsinAges 18 years+ - NCT06510868Recruiting
MDS risk study for NET patients before or after PRRT
This study looks at the risk of developing Myelodysplastic Syndrome (MDS), a blood disorder, in people with Neuroendocrine Tumors (NET) who are treated with Peptide Radionuclide Therapy (PRRT). It involves a simple blood test to check for genetic changes linked to MDS. Participating can help understand and potentially prevent this side effect.
Toronto, OntarioAges Any age - NCT06507007Recruiting
Inner ear function in Turner syndrome
This study looks at why some people with Turner syndrome have inner ear problems. It uses MRI and CBCT scans to understand the genetic and epigenetic causes.
HerningAges 18–60 - NCT06477653RecruitingPhase 2
Dupilumab for hypereosinophilic syndrome with ongoing symptoms
This trial tests if dupilumab, added to your current treatment, can help with remaining symptoms of hypereosinophilic syndrome (HES) like asthma, eczema, nasal polyps, or eosinophilic esophagitis. You may qualify if you're already on a biologic therapy that lowers eosinophils but still have bothersome symptoms.
Bethesda, MarylandAges 18–99 - NCT06373913Recruiting
PCSK9's role in kidney damage in nephrotic syndrome
This study looks at how a protein called PCSK9 might affect kidney damage in people with nephrotic syndrome. It is for adults admitted to Kolding Hospital and aims to better understand the link between this protein and kidney problems.
KoldingAges 18 years+ - NCT06465641RecruitingPhase 4
Methylphenidate for ADHD symptoms in KBG syndrome
This study tests if the medication methylphenidate (commonly used for ADHD) can help manage attention and behavior problems in people with KBG syndrome. Each person acts as their own test case to see if the drug works for them.
Nijmegen, GelderlandAges 6–20 - NCT06451874Recruiting
Exercise for older veterans with memory and walking concerns
This study tests whether personalized exercise programs can help older veterans who walk slowly and have mild memory or thinking concerns. The goal is to improve your physical and mental function.
Boston, MassachusettsAges 65 years+ - NCT06441942Recruiting
Women with heart attack or unstable angina study
This study is a registry that collects information about women who have had a heart attack or unstable angina. The goal is to learn more about how these conditions affect women and improve care for women with heart disease.
Milan, Italy MilanAges 18–100 - NCT06447376RecruitingPhase 1
Testing siltuximab before epcoritamab to prevent cytokine release syndrome
This trial tests whether giving siltuximab before epcoritamab can help prevent or reduce cytokine release syndrome (a possible side effect where the immune system overreacts). It is for people with certain types of non-Hodgkin lymphoma that have not responded well to at least two prior treatments.
Cleveland, OhioAges 18–65 - NCT06280482RecruitingPhase 1
Nicotinamide Riboside for Moyamoya in Smooth Muscle Dysfunction
This trial tests a vitamin B3 supplement called nicotinamide riboside (NR) to see if it can help people with Smooth Muscle Dysfunction Syndrome (SMDS) who have a specific gene mutation. The goal is to improve blood flow problems in the brain (moyamoya-like disease) caused by the condition.
Houston, TexasAges 1 year+ - NCT04606693Recruiting
Screening for sleep apnea before heart rhythm ablation
This study looks at whether checking for sleep apnea (breathing pauses during sleep) and treating it helps people prepare for atrial fibrillation ablation. It may help by improving outcomes for patients with atrial fibrillation who keep having episodes despite medication.
Madrid, MadridAges 18 years+ - NCT06421350Recruiting
Closed-loop spinal cord stimulation for complex regional pain syndrome
This trial tests a new type of spinal cord stimulator that automatically adjusts to your pain signals. It may help people with complex regional pain syndrome (CRPS) who have not tried this kind of therapy before.
La Jolla, CaliforniaAges 18 years+ - NCT06421506Recruiting
Giving surfactant through a thin tube in late preterm babies
This trial tests a less invasive way to give surfactant (a lung treatment) to babies born a few weeks early who need breathing help. It aims to see if this method works as well as standard care.
LondonAges 8 months–9 months - NCT06424522Recruiting
Enema program for bowel problems after rectal cancer surgery
This trial tests a special enema program to help people with ongoing bowel problems (called LARS) after rectal cancer surgery. If standard treatments haven't worked, this program might offer a new way to manage symptoms like urgency and leakage.
Columbus, OhioAges 18 years+ - NCT06430385RecruitingPhase 1/Phase 2
Study of ION440 for MECP2 Duplication Syndrome
This trial tests an experimental medicine called ION440 for people with MECP2 Duplication Syndrome. The medicine is given as an injection into the spinal fluid, and the study aims to check its safety and how well it works.
San Diego, CaliforniaAges 2–65 - NCT01522183Recruiting
Registry for people with atypical hemolytic uremic syndrome
This is a registry that collects information from people diagnosed with atypical hemolytic uremic syndrome (aHUS). It helps researchers better understand the condition across different genetic causes and treatment needs.
Aurora, ColoradoAges Any age - NCT06410352RecruitingPhase 4
Weight loss methods for longer life with metabolic syndrome
This trial tests weight loss methods in people with type 2 diabetes, high blood pressure, and excess weight. It aims to see if losing 15-20% of body weight can help people live longer and healthier.
Astana, AstanaAges 35–65 - NCT06409442Recruiting
Support and vibration for shoulder impingement
This study tests two non-invasive treatments—corrective external support (like special tape) and regional vibration—for people with subacromial impingement syndrome, a common cause of shoulder pain. It aims to see if these treatments can reduce pain and improve shoulder function.
Izmir, BalçovaAges 18 years+ - NCT06413004Recruiting
IBS and immune reactions to bacteria in the gut
This study tests whether some IBS symptoms are linked to a certain gut bacteria and an immune reaction. It aims to understand the cause of IBS to find better treatments.
GothenburgAges 18–70
Hear when a new Down Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.