Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05226624Recruiting
Improving care for babies born with opioid withdrawal
This program helps participating hospitals improve care for newborns who may go through opioid withdrawal (also called neonatal abstinence syndrome). It mainly aims to make mother-baby support and treatment plans work better after delivery.
Edmonton, AlbertaAges Any age - NCT01311258Recruiting
Tracking leftover cancer cells in AML or high-risk MDS
This study checks for “minimal residual disease,” meaning tiny numbers of leukemia cells that can remain after treatment. Results may help doctors better monitor your response and risk of relapse in AML or high-risk MDS.
Rochester, New YorkAges 18 years+ - NCT06394830RecruitingPhase 2
Testing VNX001 for bladder pain syndrome
This study tests a new treatment (VNX001) for people with interstitial cystitis or bladder pain syndrome (IC/BPS). You must have already taken part in an earlier study of this drug to join. The goal is to see if it safely reduces bladder pain.
Tucson, ArizonaAges 18 years+ - NCT06384846Recruiting
AI predicts heart attacks using white blood cells
This study tests whether an artificial intelligence tool can accurately predict a heart attack (acute coronary syndrome) by looking at the properties of your white blood cells. If successful, it could help doctors diagnose heart attacks faster from a simple blood sample.
Graz, Styria / SteiermarkAges 18 years+ - NCT06366464RecruitingPhase 3
Study of a drug for sleepiness in Prader-Willi syndrome
This trial tests a medication called pitolisant to see if it helps reduce excessive daytime sleepiness in people with Prader-Willi syndrome. You or your loved one may be able to join if they have a confirmed diagnosis and a caregiver who can regularly help with study tasks.
Los Angeles, CaliforniaAges 6 years+ - NCT06372717RecruitingPhase 1
Testing APL-4098 alone or combined for AML or MDS
This trial tests a new drug called APL-4098, given alone or with another medicine, for people with certain blood cancers (AML or MDS) that have come back or not responded to treatment. The goal is to see if it is safe and works well.
Clayton, VictoriaAges 18 years+ - NCT06371417RecruitingPhase 1
Testing RAY121 for several immune diseases (RAINBOW trial)
This trial tests a new medicine called RAY121 (an antibody) for people with certain autoimmune diseases. It aims to see if RAY121 is safe and how the body handles it. If you have one of these conditions and meet the basic health requirements, you might be able to join.
Orange, CaliforniaAges 18–85 - NCT06376500Recruiting
Brain stimulation to help thinking after concussion
This study tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can help improve thinking and memory problems that some people have after a mild concussion. tDCS uses a small electrical current from scalp electrodes to gently activate parts of the brain.
Hung Hom, KowloonAges 18–65 - NCT06373926Recruiting
Blood test for Annexin A2 in antiphospholipid syndrome
This study tests how a blood sample can help doctors better understand Antiphospholipid Syndrome (APS) by measuring a protein called Annexin A2 on white blood cells. It may lead to easier diagnosis and monitoring of this condition.
AmiensAges 18 years+ - NCT06371976Recruiting
Stress hormone system study after heart surgery
This study looks at how your body's stress hormone system (the HPA axis) works after heart surgery if you develop vasoplegic syndrome (a serious drop in blood pressure). The goal is to understand if giving extra steroids might help. If you are scheduled for heart surgery with a heart-lung machine, you may be able to join.
Paris, Île-de-France RegionAges 18 years+ - NCT06339177Recruiting
HLH study looking at immune system and genes
This study is for people with hemophagocytic lymphohistiocytosis (HLH), a condition where the immune system becomes overactive. Researchers want to collect medical data and blood samples to better understand HLH and find better ways to diagnose and treat it.
Bethesda, MarylandAges 18–120 - NCT06342999Enrolling by invitation
Fetal heart valve procedure for underdeveloped left heart
This trial tests a procedure called fetal aortic valvuloplasty (opening the baby's heart valve while still in the womb) to help the left side of the heart grow better. It's for pregnant women whose babies have a narrow aortic valve and signs that the left heart may not develop fully.
Rochester, MinnesotaAges Up to 45 years - NCT06330324Enrolling by invitation
Reproductive choices for genetic skin conditions
This study looks at the choices families have when they carry a genetic skin condition. It aims to learn more about how prenatal testing and IVF with genetic testing can help.
Maastricht, LimburgAges Any age - NCT06333041RecruitingPhase 2/Phase 3
CBD study for Sanfilippo syndrome
This study tests whether a cannabis-derived medicine called cannabidiol (CBD) can help children with Sanfilippo syndrome, a rare genetic disorder. It may be a good fit for children who have already tried other treatments or whose disease is more advanced.
Torrance, CaliforniaAges 4 years+ - NCT05693909RecruitingPhase 2
SP-420 for iron overload in certain blood disorders
This Phase 2 study tests SP-420 to help people with transfusion-related iron overload from either beta-thalassemia or low-risk myelodysplastic syndromes. It aims to see if the treatment can improve how the body handles excess iron, which builds up after repeated transfusions.
CopenhagenAges 18 years+ - NCT06303986Enrolling by invitation
Observation study for newborns with or without NAS
This study is collecting information from two groups of newborns: those with Neonatal Abstinence Syndrome (NAS, caused by drug exposure before birth) and healthy newborns. The goal is to see if an automated system makes it easier to gather data without extra tests or procedures.
Albuquerque, New MexicoAges Up to 4 weeks - NCT06304103RecruitingPhase 2
Study of AND017 for low-risk myelodysplastic syndrome
This trial tests an experimental drug called AND017 for people with a certain type of myelodysplastic syndrome (MDS) that is low-risk and not linked to a chromosome 5 deletion. The goal is to see if AND017 can help improve low red blood cell counts (anemia) and reduce or avoid the need for blood transfusions.
Hangzhou, ZhejiangAges 18–75 - NCT06280755Recruiting
AI-assisted MS care study
This study looks at how artificial intelligence (AI) can help doctors care for people with multiple sclerosis (MS) and other similar conditions. It uses existing medical data to see if AI can improve treatment decisions.
Prague, Praha 2Ages 18 years+ - NCT06287944RecruitingPhase 1
Targeted radiation and chemo before donor stem cell transplant
This trial tests a new approach: giving a targeted radioactive antibody (attached to a drug that finds CD38 on cancer cells) along with low-dose chemotherapy and targeted radiation to the bone marrow before a donor stem cell transplant. The goal is to prepare the body for the transplant while killing remaining cancer cells more precisely.
Duarte, CaliforniaAges 18–70 - NCT06292104Recruiting
Understanding POTS: A study on heart rate and standing
This study looks at how the body controls heart rate and blood flow in people with POTS (a condition that causes dizziness and a fast heart rate upon standing). It helps researchers understand POTS better by comparing patients with healthy volunteers.
Dallas, TexasAges 14 years+ - NCT06291038Recruiting
Glutamine for IBS with leaky gut
This trial tests whether a supplement called glutamine can help people with irritable bowel syndrome (IBS) who have increased gut permeability (leaky gut). It aims to see if taking glutamine improves digestive symptoms and quality of life.
AmiensAges 18–75 - NCT06271200Recruiting
Lifestyle change and medication for metabolic syndrome
This trial tests a lifestyle program combined with two medications (semaglutide and dapagliflozin) to help people with metabolic syndrome lose weight and improve their health. It may be an option if you are an adult with a BMI of 27 to 45 and have metabolic syndrome.
Zhunan, Miaoli CountyAges 20–65 - NCT06261502RecruitingPhase 2
CBD for Anxiety in Fragile X Syndrome
This trial tests if cannabidiol (CBD) can help with anxiety and improve brain function in people with Fragile X syndrome. Participants will receive CBD or a placebo, and may have brain scans (MRI) or magnetic stimulation (TMS) to see how it works.
Sherbrooke, QuebecAges 7–40 - NCT06247787RecruitingPhase 1
Imetelstat plus chemo for relapsed leukemia in kids
This trial tests a new drug called imetelstat combined with two chemotherapy drugs (fludarabine and cytarabine) for children and teens with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or juvenile myelomonocytic leukemia (JMML) that has come back or not responded to treatment. The goal is to find the safest dose of imetelstat and see if it helps control the cancer.
Birmingham, AlabamaAges 1–18
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.